Most cited papers in Neuropeptides and Animal Physiology
What are the most cited papers in Neuropeptides and Animal Physiology?
The most cited paper in Neuropeptides and Animal Physiology is "The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine" (Robert F. Furchgott, John V. Zawadzki, 1980), with 12,123 citations. Next come "Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs" (5,701) and "A simple and very efficient method for generating cDNA libraries" (4,567).
Showing 50 of 100 papers. Every paper with more than 1,294 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine Robert F. Furchgott, John V. Zawadzki · Nature | Nov 1980 | 12,123 |
| 2 | Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs C. A. Winter, Edwin A. Risley, George W. Nuss · Experimental Biology and Medicine | Dec 1962 | 5,701 |
| 3 | A simple and very efficient method for generating cDNA libraries Ueli Gubler, Beth J. Hoffman · Gene | Nov 1983 | 4,567 |
| 4 | Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner Dorothy P. Schafer, Emily K. Lehrman, Amanda G. Kautzman et al. · Neuron | May 2012 | 4,228 |
| 5 | Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin Wylie Vale, Joachim Spiess, CATHERINE L. RIVIER et al. · Science | 18 Sep 1981 | 3,979 |
| 6 | Identification of two related pentapeptides from the brain with potent opiate agonist activity Joel W. Hughes, Terry Smith, Hans Walter Kosterlitz et al. · Nature | Dec 1975 | 3,808 |
| 7 | Neurobiology of addiction: a neurocircuitry analysis George F. Koob, Nora D. Volkow · The Lancet Psychiatry | 27 Jul 2016 | 3,777 |
| 8 | Multiple receptors for dopamine John W. Kebabian, Donald B. Calne · Nature | 1979 | 3,750 |
| 9 | Dopamine Receptors: From Structure to Function Cristina Missale, Stuart Nash, Susan W. Robinson et al. · Physiological Reviews | 1998 | 3,654 |
| 10 | High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor Vadim Cherezov, Daniel M. Rosenbaum, Michael A. Hanson et al. · Science | 25 Oct 2007 | 3,296 |
| 11 | [19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors Juan Antonio Ballesteros‐Cánovas, Harel Weinstein · Methods in neurosciences | 1995 | 3,112 |
| 12 | Descending control of pain Mark John Millan · Progress in Neurobiology | Apr 2002 | 3,055 |
| 13 | Nitric oxide: an endogenous modulator of leukocyte adhesion. Paul Kubes, Motohisa Suzuki, D. Neil Granger · Proceedings of the National Academy of Sciences | Jun 1991 | 3,055 |
| 14 | Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation Thien-Khai H. Vu, David T. Hung, Virginia I. Wheaton et al. · Cell | Mar 1991 | 3,007 |
| 15 | Trends in GPCR drug discovery: new agents, targets and indications Alexander S. Hauser, Misty M. Attwood, Mathias Rask‐Andersen et al. · Nature Reviews Drug Discovery | 27 Oct 2017 | 2,779 |
| 16 | Seven-transmembrane receptors Kristen L. Pierce, Richard T. Premont, Robert J. Lefkowitz · Nature Reviews Molecular Cell Biology | Sep 2002 | 2,739 |
| 17 | Secretory products of macrophages. Carl Nathan · Journal of Clinical Investigation | Feb 1987 | 2,651 |
| 18 | The structure and function of G-protein-coupled receptors Daniel M. Rosenbaum, Søren G. F. Rasmussen, Brian K. Kobilka · Nature | May 2009 | 2,595 |
| 19 | International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors Bertil B. Fredholm, Adriaan P. IJzerman, Kenneth A. Jacobson et al. · Pharmacological Reviews | Dec 2001 | 2,575 |
| 20 | Trk Receptors: Roles in Neuronal Signal Transduction Eric Jinsheng Huang, Louis French Reichardt · Annual Review of Biochemistry | 31 Mar 2003 | 2,567 |
| 21 | Endogenous opioid peptides: multiple agonists and receptors John A.H. Lord, Angela A. Waterfield, John M. Hughes et al. · Nature | Jun 1977 | 2,491 |
| 22 | The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids Andrew J. Brown et al. · Journal of Biological Chemistry | Mar 2003 | 2,411 |
| 23 | Opiate Receptor: Demonstration in Nervous Tissue Candace B. Pert, Solomon H. Snyder · Science | 9 Mar 1973 | 2,386 |
| 24 | Gut hormone PYY3-36 physiologically inhibits food intake Rachel Louise Batterham, Michael Alexander Cowley, Caroline J. Small et al. · Nature | Aug 2002 | 2,361 |
| 25 | Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing Michael G. Rosenfeld, Jean‐Jacques Mermod, Susan Amara et al. · Nature | Jul 1983 | 2,332 |
| 26 | Neurotrophins and their receptors: A convergence point for many signalling pathways Moses V. Chao · Nature reviews. Neuroscience | Apr 2003 | 2,327 |
| 27 | Immunodesign of experimental sepsis by cecal ligation and puncture Daniel Rittirsch, Markus Stefan Huber-Lang, Michael A. Flierl et al. · Nature Protocols | 11 Dec 2008 | 2,296 |
| 28 | Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide Kazuhiko Tatemoto, Mats Carlquist, Viktor Mutt · Nature | Apr 1982 | 2,281 |
| 29 | Adrenomedullin: A Novel Hypotensive Peptide Isolated from Human Pheochromocytoma Kenichiro Kitamura, Kenji Kangawa, Masashi Kawamoto et al. · Biochemical and Biophysical Research Communications | Apr 1993 | 2,216 |
| 30 | High serum procalcitonin concentrations in patients with sepsis and infection Marcel Assicot, Claude Bohuon, D Gendrel et al. · The Lancet | Feb 1993 | 2,211 |
| 31 | The formalin test in mice: dissociation between inflammatory and non-inflammatory pain Steinar Hunskaar, Kjell Jorgen Hole · Pain | Jul 1987 | 2,200 |
| 32 | RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor Linda M. McLatchie, Neil J. Fraser, Martin J. Main et al. · Nature | May 1998 | 2,163 |
| 33 | Calcitonin gene-related peptide is a potent vasodilator Susan Diana Brain, Tanya J. Williams, John R. Tippins et al. · Nature | 1985 | 2,104 |
| 34 | Drugs of abuse: anatomy, pharmacology and function of reward pathways George F. Koob · Trends in Pharmacological Sciences | 1992 | 2,095 |
| 35 | Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides Bruce A. Yankner, Lawrence Kevin Duffy, Daniel A. Kirschner · Science | 12 Oct 1990 | 1,991 |
| 36 | COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression Naduviladath Vishvanath Chandrasekharan, Hu Dai, Katarina Roos et al. · Proceedings of the National Academy of Sciences | 19 Sep 2002 | 1,990 |
| 37 | BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain Jeffrey A. M. Coull, Simon A. S. Beggs, Dominic Boudreau et al. · Nature | Dec 2005 | 1,969 |
| 38 | A role for glucagon-like peptide-1 in the central regulation of feeding Mandy D. Turton, Donal O’Shea, Irene Gunn et al. · Nature | 1996 | 1,961 |
| 39 | Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor Jean‐Claude Meunier, Catherine Mollereau, Lawrence Toll et al. · Nature | 12 Oct 1995 | 1,919 |
| 40 | Tumor Necrosis Factor (TNF) Lloyd J. Old · Science | 8 Nov 1985 | 1,916 |
| 41 | Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Ted M. Dawson, David S. Bredt, Majid Fotuhi et al. · Proceedings of the National Academy of Sciences | Sep 1991 | 1,858 |
| 42 | Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells Atsuro Miyata, Akira Arimura, Raymond R. Dahl et al. · Biochemical and Biophysical Research Communications | Oct 1989 | 1,853 |
| 43 | Role of endothelium-derived nitric oxide in the regulation of blood pressure. Daryl D. Rees, Richard M. J. Palmer, Salvador Moncada · Proceedings of the National Academy of Sciences | May 1989 | 1,836 |
| 44 | Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling Stephen S. G. Ferguson · Pharmacological Reviews | Mar 2001 | 1,830 |
| 45 | A new natriuretic peptide in porcine brain Tetsuji Sudoh, Kenji Kangawa, Naoto Minamino et al. · Nature | Mar 1988 | 1,827 |
| 46 | Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor Rainer K. Reinscheid, Hans‐Peter Nothacker, Anne Bourson et al. · Science | 3 Nov 1995 | 1,826 |
| 47 | Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas Robson A.S. Santos, Ana Cristina Simões e Silva, Christine Maric et al. · Proceedings of the National Academy of Sciences | 26 Jun 2003 | 1,819 |
| 48 | Ghrelin, a Novel Growth Hormone-Releasing Acylated Peptide, Is Synthesized in a Distinct Endocrine Cell Type in the Gastrointestinal Tracts of Rats and Humans1 Yukari Date, Masayasu Kojima, Hiroshi Hosoda et al. · Endocrinology | Nov 2000 | 1,817 |
| 49 | The 2.6 Angstrom Crystal Structure of a Human A 2A Adenosine Receptor Bound to an Antagonist Veli‐Pekka Jaakola, Mark T. Griffith, Michael A. Hanson et al. · Science | 2 Oct 2008 | 1,789 |
| 50 | The neuropathic pain triad: neurons, immune cells and glia Joachim Scholz, Clifford J. Woolf · Nature Neuroscience | 26 Oct 2007 | 1,761 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.