Topic · NF-κB Signaling Pathways
Most cited papers in NF-κB Signaling Pathways
What are the most cited papers in NF-κB Signaling Pathways?
The most cited paper in NF-κB Signaling Pathways is "NF-κB signaling in inflammation" (Ting Liu, Lingyun Zhang, Donghyun Joo et al., 2017), with 8,517 citations. Next come "Toll-Like Receptors" (6,179) and "Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death" (6,042).
Showing 50 of 100 papers. Every paper with more than 1,984 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | NF-κB signaling in inflammation Ting Liu, Lingyun Zhang, Donghyun Joo et al. · Signal Transduction and Targeted Therapy | 14 Jul 2017 | 8,517 |
| 2 | Toll-Like Receptors Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira · Annual Review of Immunology | 3 Mar 2003 | 6,179 |
| 3 | Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death Zoltán N. Oltval, Curt L. Milliman, Stanley J. Korsmeyer · Cell | Aug 1993 | 6,042 |
| 4 | THE NF-κB AND IκB PROTEINS: New Discoveries and Insights Albert S. Baldwin · Annual Review of Immunology | Apr 1996 | 5,979 |
| 5 | NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses Sankar Ghosh, Michael J. May, Elizabeth B. Kopp · Annual Review of Immunology | Apr 1998 | 5,209 |
| 6 | Mammalian MAP kinase signalling cascades Lufen Chang, Michael Karin · Nature | Mar 2001 | 5,148 |
| 7 | Apoptosis by Death Factor Shigekazu Nagata · Cell | Feb 1997 | 5,008 |
| 8 | The Nuclear Factor NF- B Pathway in Inflammation Toby Lawrence · Cold Spring Harbor Perspectives in Biology | 7 Oct 2009 | 4,962 |
| 9 | Shared Principles in NF-κB Signaling Matthew S. Hayden, Sankar Ghosh · Cell | Feb 2008 | 4,836 |
| 10 | Toll-like receptors: critical proteins linking innate and acquired immunity Shizuo Akira, Kiyoshi Takeda, Tsuneyasu Kaisho · Nature Immunology | Aug 2001 | 4,814 |
| 11 | Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity Michael Karin, Yinon Ben‐Neriah · Annual Review of Immunology | Apr 2000 | 4,784 |
| 12 | Function and Activation of NF-kappaB in the Immune System Patrick A. Baeuerle, Thomas Henkel · Annual Review of Immunology | Apr 1994 | 4,729 |
| 13 | Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases Peter John Barnes, Michael Karin · New England Journal of Medicine | 10 Apr 1997 | 4,699 |
| 14 | Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation A H Wyllie · Nature | Apr 1980 | 4,548 |
| 15 | NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses Konstantin D. Taganov, Mark Boldin, Kuang‐Jung Chang et al. · Proceedings of the National Academy of Sciences | 2 Aug 2006 | 4,341 |
| 16 | Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 David Allen Barbie et al. · Nature | 21 Oct 2009 | 4,303 |
| 17 | NF-κB regulation in the immune system Qiutang Li, Inder M. Verma · Nature reviews. Immunology | Oct 2002 | 4,031 |
| 18 | NF-κB: a key role in inflammatory diseases Paul Peter Tak, Gary S. Firestein · Journal of Clinical Investigation | 2001 | 3,919 |
| 19 | Signaling to NF-κB Matthew S. Hayden, Sankar Ghosh · Genes & Development | 15 Sep 2004 | 3,835 |
| 20 | Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1. Ralf Schreck, PETER RIEBER, Patrick A. Baeuerle · The EMBO Journal | Aug 1991 | 3,832 |
| 21 | Activators and target genes of Rel/NF-κB transcription factors Heike Luise Pahl · Oncogene | 22 Nov 1999 | 3,715 |
| 22 | The TNF and TNF Receptor Superfamilies Richard M. Locksley, Nigel P. Killeen, Michael J. Lenardo · Cell | Feb 2001 | 3,648 |
| 23 | Missing Pieces in the NF-κB Puzzle Sankar Ghosh, Michael Karin · Cell | Apr 2002 | 3,643 |
| 24 | Nuclear factor-κB in cancer development and progression Michael Karin · Nature | May 2006 | 3,552 |
| 25 | Crosstalk of reactive oxygen species and NF-κB signaling Michael J Morgan, Zheng-gang Liu · Cell Research | 28 Dec 2010 | 3,489 |
| 26 | Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai et al. · The Journal of Immunology | Apr 1999 | 3,391 |
| 27 | OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis Young‐Yun Kong, Hiroki Yoshida, Ildiko Sarosi et al. · Nature | 1999 | 3,385 |
| 28 | Toll-like receptors in innate immunity Kiyoshi Takeda · International Immunology | 22 Nov 2004 | 3,326 |
| 29 | A protein kinase involved in the regulation of inflammatory cytokine biosynthesis John C. Lee, Jeffrey T. Laydon, Peter McDonnell et al. · Nature | Dec 1994 | 3,317 |
| 30 | LPS/TLR4 signal transduction pathway Yong‐Chen Lu, Wen‐Chen Yeh, Pamela S. Ohashi · Cytokine | 7 Mar 2008 | 3,314 |
| 31 | Toll-Like Receptor Signaling Pathways Takumi Kawasaki, Taro Kawai · Frontiers in Immunology | 25 Sep 2014 | 3,301 |
| 32 | Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway Masahiro Yamamoto, Shintaro Sato, Hiroaki Hemmi et al. · Science | 14 Jul 2003 | 3,259 |
| 33 | The pro- and anti-inflammatory properties of the cytokine interleukin-6 Jürgen Scheller, Athena Chalaris, Dirk Schmidt‐Arras et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 5 Feb 2011 | 3,248 |
| 34 | The complexity of NF-κB signaling in inflammation and cancer Bastian Hoesel, Johannes A. Schmid · Molecular Cancer | 2013 | 3,232 |
| 35 | JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain Benoit Dérijard, Masahiko Hibi, I‐Huan Wu et al. · Cell | Mar 1994 | 3,222 |
| 36 | A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD Masato Enari, Hideki Sakahira, Hideki Yokoyama et al. · Nature | 1998 | 3,204 |
| 37 | Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene Michael E. Greenberg, Edward Benjamin Ziff · Nature | Oct 1984 | 3,188 |
| 38 | Activators and Target Genes of Rel/NF-кB Transcription Factors Torsten Loop, Heike Luise Pahl | 2003 | 3,183 |
| 39 | A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells Roy A. Black, Charles T. Rauch, Carl J. Kozlosky et al. · Nature | Feb 1997 | 3,168 |
| 40 | NF-κB: linking inflammation and immunity to cancer development and progression Michael Karin, Florian R. Greten · Nature reviews. Immunology | 20 Sep 2005 | 3,088 |
| 41 | An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death Amer A. Beg, David Baltimore · Science | Nov 1996 | 3,082 |
| 42 | NF-κB: Ten Years After Patrick A. Baeuerle, David Baltimore · Cell | Oct 1996 | 3,019 |
| 43 | The NF- B Family of Transcription Factors and Its Regulation Andrea Oeckinghaus, Sankar Ghosh · Cold Spring Harbor Perspectives in Biology | 2 Sep 2009 | 2,889 |
| 44 | An essential role for Scurfin in CD4+CD25+ T regulatory cells Roli Khattri, Tom Cox, Sue-Ann Yasayko et al. · Nature Immunology | 3 Mar 2003 | 2,862 |
| 45 | Signalling pathways of the TNF superfamily: a double-edged sword Bharat Bhushan Aggarwal · Nature reviews. Immunology | Sep 2003 | 2,806 |
| 46 | NF-κB, inflammation, immunity and cancer: coming of age Koji Taniguchi, Michael Karin · Nature reviews. Immunology | 22 Jan 2018 | 2,765 |
| 47 | Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase Liming Sun, Huayi Wang, Zhigao Wang et al. · Cell | 2012 | 2,749 |
| 48 | Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase Fan Yeung, Jamie E. Hoberg, C S Ramsey et al. · The EMBO Journal | 20 May 2004 | 2,747 |
| 49 | Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes Olivier Micheau, Jürg Tschopp · Cell | Jul 2003 | 2,735 |
| 50 | NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation Cun-Yu Wang, Marty W. Mayo, Robert G. Korneluk et al. · Science | 11 Sep 1998 | 2,728 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.