Topic · Nuclear Receptors and Signaling
Most cited papers in Nuclear Receptors and Signaling
What are the most cited papers in Nuclear Receptors and Signaling?
The most cited paper in Nuclear Receptors and Signaling is "Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families" (Elizabeth H. Corder, Ann M. Saunders, Warren J. Strittmatter et al., 1993), with 9,582 citations. Next come "α-Synuclein in Lewy bodies" (8,529) and "Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease" (8,336).
Showing 50 of 100 papers. Every paper with more than 1,183 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families Elizabeth H. Corder, Ann M. Saunders, Warren J. Strittmatter et al. · Science | 13 Aug 1993 | 9,582 |
| 2 | α-Synuclein in Lewy bodies Maria Grazia Spillantini, Marie Luise Schmidt, Virginia M.‐Y. Lee et al. · Nature | 28 Aug 1997 | 8,529 |
| 3 | Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease Mihael H. Polymeropoulos, Christian N. Lavedan, Elisabeth Leroy et al. · Science | 27 Jun 1997 | 8,336 |
| 4 | Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor Anne Sophie Brunet, Azad Bonni, Michael J. Zigmond et al. · Cell | Mar 1999 | 6,632 |
| 5 | Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism Tohru Kitada, Shuichi Asakawa, Nobutaka Hattori et al. · Nature | Apr 1998 | 5,278 |
| 6 | Cloning of a novel receptor expressed in rat prostate and ovary. George G. J. M. Kuiper, Eva Enmark, Markku Pelto‐Huikko et al. · Proceedings of the National Academy of Sciences | 11 Jun 1996 | 4,820 |
| 7 | α-Synuclein Locus Triplication Causes Parkinson's Disease A. B. Singleton et al. · Science | 30 Oct 2003 | 4,456 |
| 8 | Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice Karen Hsiao, Paul F. Chapman, Steven P. Nilsen et al. · Science | 4 Oct 1996 | 4,247 |
| 9 | Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles Salvatore Oddo, Antonella Caccamo, Jason D. Shepherd et al. · Neuron | Jul 2003 | 4,207 |
| 10 | Epidemiology of Parkinson's disease Lonneke ML de Lau, Monique M.B. Breteler · The Lancet Neurology | 20 May 2006 | 4,142 |
| 11 | AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease Rejko Krüger, Wilfried Kuhn, Thomas H. Müller et al. · Nature Genetics | Feb 1998 | 3,923 |
| 12 | Chronic systemic pesticide exposure reproduces features of Parkinson's disease Ranjita S. Betarbet, Todd Sherer, Gillian M. MacKenzie et al. · Nature Neuroscience | Dec 2000 | 3,729 |
| 13 | Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation Holly D. Oakley, Sarah L. Cole, Sreemathi Logan et al. · Journal of Neuroscience | 4 Oct 2006 | 3,665 |
| 14 | The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation Peter E. Angel, Michael Karin · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | Dec 1991 | 3,422 |
| 15 | The RXR heterodimers and orphan receptors David J. Mangelsdorf, Ronald M. Evans · Cell | Dec 1995 | 3,195 |
| 16 | The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease Jeff Sevigny et al. · Nature | 30 Aug 2016 | 3,131 |
| 17 | Pathways towards and away from Alzheimer's disease Mark P. Mattson · Nature | 4 Aug 2004 | 3,075 |
| 18 | Mechanisms and Functional Implications of Adult Neurogenesis Chunmei Zhao, Wei Deng, Fred H. Gage · Cell | Feb 2008 | 3,013 |
| 19 | AP-1 function and regulation Michael Karin, Zheng-gang Liu, Ebrahim Zandi · Current Opinion in Cell Biology | Apr 1997 | 2,941 |
| 20 | 15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ BARRY MARC FORMAN, Peter Tontonoz, Jasmine Chen et al. · Cell | Dec 1995 | 2,866 |
| 21 | Delayed neuronal death in the gerbil hippocampus following ischemia Takaaki Kirino · Brain Research | May 1982 | 2,858 |
| 22 | Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism Vincenzo Bonifati, Patrizia Rizzu, Marijke J. van Baren et al. · Science | 9 Jan 2003 | 2,807 |
| 23 | The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia Juan Jose Zarranz, Javier Alegre, Juan Carlos Gómez‐Esteban et al. · Annals of Neurology | 30 Dec 2003 | 2,780 |
| 24 | The molecular pathology of Alzheimer's disease Dennis J. Selkoe · Neuron | Apr 1991 | 2,750 |
| 25 | Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun James I. Morgan, Tom Curran · Annual Review of Neuroscience | Mar 1991 | 2,674 |
| 26 | The many roles of histone deacetylases in development and physiology: implications for disease and therapy Michael Haberland, Rusty L. Montgomery, Eric N. Olson · Nature Reviews Genetics | 9 Dec 2008 | 2,568 |
| 27 | Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030 Earl Ray Dorsey, Radu Constantinescu, James P. Thompson et al. · Neurology | 3 Nov 2006 | 2,508 |
| 28 | The regulation and function of c-fos and other immediate early genes in the nervous system Morgan Sheng, Michael E. Greenberg · Neuron | Apr 1990 | 2,470 |
| 29 | The expanding role of mitochondria in apoptosis. X. Wang · PubMed | 15 Nov 2001 | 2,384 |
| 30 | The coregulator exchange in transcriptional functions of nuclear receptors Christopher K. Glass, Michael G. Rosenfeld · Genes & Development | 15 Jan 2000 | 2,253 |
| 31 | The prevalence of Parkinson's disease: A systematic review and meta‐analysis Tamara M. Pringsheim, Nathalie Jetté, Alexandra D. Frolkis et al. · Movement Disorders | 28 Jun 2014 | 2,214 |
| 32 | mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Peter Tontonoz, Elise Hu, Reed A. Graves et al. · Genes & Development | 15 May 1994 | 2,189 |
| 33 | A Century of Alzheimer's Disease Michel Goedert, Maria Grazia Spillantini · Science | 2 Nov 2006 | 2,127 |
| 34 | α-synuclein locus duplication as a cause of familial Parkinson's disease Marie‐Christine Chartier‐Harlin, Jennifer M. Kachergus, Christophe Roumier et al. · The Lancet | Sep 2004 | 2,070 |
| 35 | Oxidative stress in Parkinson's disease Peter Jenner · Annals of Neurology | 2003 | 2,064 |
| 36 | Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease Sonja Kriks, Jaewon Shim, Jinghua Piao et al. · Nature | 4 Nov 2011 | 1,965 |
| 37 | Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease Elizabeth H. Corder, Ann M. Saunders, NEIL J. RISCH et al. · Nature Genetics | Jun 1994 | 1,941 |
| 38 | Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ Laszlo Tibor Nagy, Peter Tontonoz, Jacqueline G. A. Alvarez et al. · Cell | Apr 1998 | 1,874 |
| 39 | Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation Jiayi Li, Elisabet M. Englund, Janice L. Holton et al. · Nature Medicine | 6 Apr 2008 | 1,874 |
| 40 | The epidemiology of Parkinson's disease: risk factors and prevention Alberto Ascherio, Michael A. Schwarzschild · The Lancet Neurology | 11 Oct 2016 | 1,866 |
| 41 | Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites Kolja Paech, Paul M. Webb, George G. J. M. Kuiper et al. · Science | 5 Sep 1997 | 1,865 |
| 42 | MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription Maria H. Chahrour, Sung Yun Jung, Chad A. Shaw et al. · Science | 29 May 2008 | 1,859 |
| 43 | Levodopa and the Progression of Parkinson's Disease The Parkinson Study Group · New England Journal of Medicine | 9 Dec 2004 | 1,835 |
| 44 | The PPARs: From Orphan Receptors to Drug Discovery Timothy Mark Willson, Peter J. Brown, Daniel D. Sternbach et al. · Journal of Medicinal Chemistry | Feb 2000 | 1,816 |
| 45 | Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin Ira E. Clark, Mark W. Dodson, Changan Jiang et al. · Nature | 3 May 2006 | 1,810 |
| 46 | Alzheimer Mechanisms and Therapeutic Strategies Yadong Huang, Lennart Mucke · Cell | Mar 2012 | 1,788 |
| 47 | The Role of Oxidative Stress in Parkinson's Disease Vera Dias, Eunsung Junn, M. Maral Mouradian · Journal of Parkinson s Disease | 2013 | 1,784 |
| 48 | Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen Christopher J. Phiel, Fang Zhang, Eric Yi‐Hsiu Huang et al. · Journal of Biological Chemistry | Sep 2001 | 1,766 |
| 49 | Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease Jeffrey H. Kordower, Yaping Chu, Robert A. Hauser et al. · Nature Medicine | 6 Apr 2008 | 1,743 |
| 50 | Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin Jeehye Park, Sung Bae Lee, Sungkyu Lee et al. · Nature | 3 May 2006 | 1,731 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.