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Topic · Cellular and Molecular Neuroscience

Nuclear Receptors and Signaling

Nuclear Receptors and Signaling is a research topic within Cellular and Molecular Neuroscience. Science Explorer counts 16k research works in it since 1951. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the Nurr1/CoREST pathway and its role in protecting dopaminergic neurons from inflammation-induced death, with implications for neurodegenerative diseases such as Parkinson's. The research covers topics such as mitochondrial targeting, nuclear receptors, transcriptional regulation, and apoptosis.

  • Nurr1
  • NR4A2
  • dopaminergic neurons
  • Parkinson's disease
  • inflammation
  • mitochondrial targeting
  • nuclear receptors
  • neurodegeneration
  • transcriptional regulation
  • apoptosis
Research works
16k
fractional, since 1951
In the world top 10%
1.6k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+9%
the tick is no change
Largest producer
China
40% of the 10 largest, 2022-now
Nuclear Receptors and Signaling

Which countries lead Nuclear Receptors and Signaling research?

By volume, China and the United States publish the most (888 and 607 works in 2022-now).

By volume, 2022-now

  1. 1 China 888 works
  2. 2 United States 607 works
  3. 3 India 191 works
  4. 4 Germany 94 works
  5. 5 Japan 90 works
  6. 6 South Korea 87 works
  7. 7 United Kingdom 84 works
  8. 8 Italy 82 works
  9. 9 Canada 60 works
  10. 10 Spain 56 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 39.7%United States: 27.1%India: 8.5%Germany: 4.2%6 others listed: 20.5%40%largest
China888 · 39.7%United States607 · 27.1%India191 · 8.5%Germany94 · 4.2%6 others listed458 · 20.5%

Shares of the rows listed above, not of the whole node.

Which institutions lead Nuclear Receptors and Signaling research?

By volume in 2022-now, Harvard University publishes the most Nuclear Receptors and Signaling research, followed by Central South University and Sun Yat-sen University.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 23 works
  2. 2 Central South UniversityChina 22 works
  3. 3 Sun Yat-sen UniversityChina 20 works
  4. 4 Nanjing Medical UniversityChina 20 works
  5. 5 Shanghai Jiao Tong UniversityChina 19 works
  6. 6 Russian Academy of SciencesRussia 18 works
  7. 7 Fudan UniversityChina 16 works
  8. 8 Sichuan UniversityChina 16 works
  9. 9 Huazhong University of Science and TechnologyChina 15 works
  10. 10 National Institutes of HealthUnited States 15 works

Who are the leading researchers in Nuclear Receptors and Signaling?

The most-cited researchers publishing on Nuclear Receptors and Signaling include Guido Kroemer, Jun Wang and John P. A. Ioannidis.

  1. 1 Guido Kroemer France 386k citations
  2. 2 Jun Wang China 340k citations
  3. 3 John P. A. Ioannidis United States 317k citations
  4. 4 Gregory Y.H. Lip United Kingdom 311k citations
  5. 5 John Q. Trojanowski United States 286k citations
  6. 6 Luigi Ferrucci United States 281k citations
  7. 7 Michael Karin United States 276k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Nuclear Receptors and Signaling?

The most cited paper in Nuclear Receptors and Signaling is "Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families" (Elizabeth H. Corder, Ann M. Saunders, Warren J. Strittmatter et al., 1993), with 9,582 citations. Next come "α-Synuclein in Lewy bodies" (8,529) and "Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease" (8,336).

Most cited papers
#PaperReleasedCitations
1 Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families Elizabeth H. Corder, Ann M. Saunders, Warren J. Strittmatter et al. · Science 13 Aug 1993 9,582
2 α-Synuclein in Lewy bodies Maria Grazia Spillantini, Marie Luise Schmidt, Virginia M.‐Y. Lee et al. · Nature 28 Aug 1997 8,529
3 Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease Mihael H. Polymeropoulos, Christian N. Lavedan, Elisabeth Leroy et al. · Science 27 Jun 1997 8,336
4 Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor Anne Sophie Brunet, Azad Bonni, Michael J. Zigmond et al. · Cell Open access Mar 1999 6,632
5 Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism Tohru Kitada, Shuichi Asakawa, Nobutaka Hattori et al. · Nature Apr 1998 5,278
All 100 most cited papers, with filters and sorting

Where is Nuclear Receptors and Signaling research done?

The largest centres of Nuclear Receptors and Signaling research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Nanjing (China).

Largest cities, 2022-now

  1. 1 BeijingChina 81 works
  2. 2 ShanghaiChina 65 works
  3. 3 GuangzhouChina 58 works
  4. 4 NanjingChina 43 works
  5. 5 WuhanChina 38 works
  6. 6 SeoulSouth Korea 37 works
  7. 7 LondonUnited Kingdom 37 works
  8. 8 ChangshaChina 36 works
  9. 9 New YorkUnited States 30 works
  10. 10 HangzhouChina 30 works
See Nuclear Receptors and Signaling on the map

Where is the best place to study Nuclear Receptors and Signaling?

Among universities, judged by research, Harvard University, Johns Hopkins University and Ludwig-Maximilians-Universität München score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 15.29%fractional works in this field (log) →share of work in the world top 10% →Ludwig-Maximilians-U…Johns Hopkins Univer…Karolinska InstitutetHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 78.115.5%2.9×23 +9.4%
2Johns Hopkins UniversityUnited States 63.620.5%3.1×12 +0.6%
3Ludwig-Maximilians-Universität MünchenGermany 61.821.4%4.5×10 +24.9%
4Karolinska InstitutetSweden 61.119.1%6.2×9 +20.8%
5Sun Yat-sen UniversityChina 60.412.8%3.9×20 +44.1%
6University College LondonUnited Kingdom 60.218.0%2.5×10 +20.2%
7Nanjing Medical UniversityChina 56.98.2%8.7×20 +47.5%
8Huazhong University of Science and TechnologyChina 56.116.3%3.3×15 +69.9%
9Central South UniversityChina 54.17.3%4.5×22 +34.8%
10McGill UniversityCanada 53.313.8%4.0×10 +39.9%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Nuclear Receptors and Signaling, country by country

Is Nuclear Receptors and Signaling research growing?

Output in 2022-2025 was 9% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Nuclear Receptors and Signaling.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Nuclear Receptors and Signaling as a percentage of every work published that year, 0.013% in 2024.

still counting0.010%0.020%0.030%Nuclear Receptors and Signaling0.013% in 202519801990200020102020

Fractional works of Nuclear Receptors and Signaling over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Nuclear Receptors and Signaling10.4% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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