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Topic · Cellular and Molecular Neuroscience

Axon Guidance and Neuronal Signaling

Axon Guidance and Neuronal Signaling is a research topic within Cellular and Molecular Neuroscience. Science Explorer counts 15k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the molecular mechanisms and signaling pathways involved in axon guidance, neuronal polarity, and vascular patterning. It covers a wide range of topics including the roles of Eph receptors, Semaphorins, Netrins, and their interactions in regulating growth cone dynamics and neural development. The papers also delve into the involvement of receptor tyrosine kinases in these processes.

  • Eph receptors
  • Semaphorins
  • Netrins
  • Neuronal polarity
  • Axon guidance
  • Cell signaling
  • Neural development
  • Vascular patterning
  • Growth cone dynamics
  • Receptor tyrosine kinases
Research works
15k
fractional, since 1950
In the world top 10%
1.5k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-18%
the tick is no change
Largest producer
China
34% of the 10 largest, 2022-now
Axon Guidance and Neuronal Signaling

Which countries lead Axon Guidance and Neuronal Signaling research?

By volume, China and the United States publish the most (462 and 430 works in 2022-now).

By volume, 2022-now

  1. 1 China 462 works
  2. 2 United States 430 works
  3. 3 Japan 124 works
  4. 4 Germany 69 works
  5. 5 United Kingdom 57 works
  6. 6 France 52 works
  7. 7 India 48 works
  8. 8 Canada 46 works
  9. 9 Italy 43 works
  10. 10 Spain 37 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 33.8%United States: 31.4%Japan: 9.1%Germany: 5.1%6 others listed: 20.7%34%largest
China462 · 33.8%United States430 · 31.4%Japan124 · 9.1%Germany69 · 5.1%6 others listed283 · 20.7%

Shares of the rows listed above, not of the whole node.

Which institutions lead Axon Guidance and Neuronal Signaling research?

By volume in 2022-now, Centre National de la Recherche Scientifique publishes the most Axon Guidance and Neuronal Signaling research, followed by Harvard University and Shanghai Jiao Tong University.

By volume, 2022-now

  1. 1 Centre National de la Recherche ScientifiqueFrance 18 works
  2. 2 Harvard UniversityUnited States 16 works
  3. 3 Shanghai Jiao Tong UniversityChina 13 works
  4. 4 Fudan UniversityChina 12 works
  5. 5 Sun Yat-sen UniversityChina 12 works
  6. 6 InsermFrance 12 works
  7. 7 Nanjing Medical UniversityChina 11 works
  8. 8 Nantong UniversityChina 11 works
  9. 9 Johns Hopkins UniversityUnited States 10 works
  10. 10 Huazhong University of Science and TechnologyChina 10 works

Who are the leading researchers in Axon Guidance and Neuronal Signaling?

The most-cited researchers publishing on Axon Guidance and Neuronal Signaling include Shizuo Akira, Jun Wang and John Q. Trojanowski.

  1. 1 Shizuo Akira Japan 342k citations
  2. 2 Jun Wang China 340k citations
  3. 3 John Q. Trojanowski United States 286k citations
  4. 4 George M. Whitesides United States 267k citations
  5. 5 Hans C. Clevers Netherlands 260k citations
  6. 6 Ralph B. D’Agostino United States 255k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Axon Guidance and Neuronal Signaling?

The most cited paper in Axon Guidance and Neuronal Signaling is "Neurogenesis in the adult human hippocampus" (Peter S. Eriksson, Ekaterina Perfilieva, Thomas Björk‐Eriksson et al., 1998), with 6,370 citations. Next come "Signal transduction by receptors with tyrosine kinase activity" (5,534) and "Neurotrophins: Roles in Neuronal Development and Function" (4,433).

Most cited papers
#PaperReleasedCitations
1 Neurogenesis in the adult human hippocampus Peter S. Eriksson, Ekaterina Perfilieva, Thomas Björk‐Eriksson et al. · Nature Medicine Nov 1998 6,370
2 Signal transduction by receptors with tyrosine kinase activity Axel Ullrich, Joseph Schlessinger · Cell Apr 1990 5,534
3 Neurotrophins: Roles in Neuronal Development and Function Eric Jinsheng Huang, Louis French Reichardt · Annual Review of Neuroscience ReviewOpen access Mar 2001 4,433
4 Cell Signaling by Receptor Tyrosine Kinases Joseph Schlessinger · Cell Open access Oct 2000 3,783
5 Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis Peter C. Maisonpierre, Chitra Suri, Pamela F. Jones et al. · Science 4 Jul 1997 3,588
All 99 most cited papers, with filters and sorting

Where is Axon Guidance and Neuronal Signaling research done?

The largest centres of Axon Guidance and Neuronal Signaling research in 2022-now are Shanghai (China), Beijing (China), Tokyo (Japan) and Paris (France).

Largest cities, 2022-now

  1. 1 ShanghaiChina 47 works
  2. 2 BeijingChina 41 works
  3. 3 TokyoJapan 33 works
  4. 4 ParisFrance 27 works
  5. 5 GuangzhouChina 26 works
  6. 6 New YorkUnited States 20 works
  7. 7 WuhanChina 20 works
  8. 8 LondonUnited Kingdom 19 works
  9. 9 NanjingChina 19 works
  10. 10 HangzhouChina 18 works
See Axon Guidance and Neuronal Signaling on the map

Where is the best place to study Axon Guidance and Neuronal Signaling?

Among universities, judged by research, Harvard University, Stanford University and Johns Hopkins University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 15.33%fractional works in this field (log) →share of work in the world top 10% →Shanghai Jiao Tong U…Stanford UniversityJohns Hopkins Univer…Harvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 64.89.2%3.4×16 -32.6%
2Stanford UniversityUnited States 61.017.9%3.9×8 +27.5%
3Johns Hopkins UniversityUnited States 54.015.7%4.7×10 -42.5%
4Shanghai Jiao Tong UniversityChina 50.220.4%3.2×13 -14.4%
5Sichuan UniversityChina 45.120.5%2.8×9 +44.0%
6Fudan UniversityChina 44.712.8%5.4×12 +5.0%
7Sun Yat-sen UniversityChina 42.814.8%4.0×12 +4.7%
8Nantong UniversityChina 38.310.5%16.4×11 +23.9%
9Chongqing Medical UniversityChina 35.515.0%11.3×9 +24.5%
10Case Western Reserve UniversityUnited States 34.016.5%9.7×8 -20.6%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Axon Guidance and Neuronal Signaling, country by country

Is Axon Guidance and Neuronal Signaling research growing?

Output in 2022-2025 was 18% lower than in 2018-2021, peaking in 2013.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Axon Guidance and Neuronal Signaling as a percentage of every work published that year, 0.0062% in 2024.

still counting0.010%0.020%0.030%Axon Guidance and Neuronal Signaling0.0070% in 202519801990200020102020

Fractional works of Axon Guidance and Neuronal Signaling over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Axon Guidance and Neuronal Signaling10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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