Topic · Pancreatic function and diabetes
Most cited papers in Pancreatic function and diabetes
What are the most cited papers in Pancreatic function and diabetes?
The most cited paper in Pancreatic function and diabetes is "Positional cloning of the mouse obese gene and its human homologue" (Yiying Zhang, Ricardo Proenca, Margherita Maffei et al., 1994), with 13,483 citations. Next come "Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes" (7,908) and "Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche" (7,361).
Showing 50 of 99 papers. Every paper with more than 1,976 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Positional cloning of the mouse obese gene and its human homologue Yiying Zhang, Ricardo Proenca, Margherita Maffei et al. · Nature | Dec 1994 | 13,483 |
| 2 | Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes Bruce Charles Neal, Vlado Perkovic, Kenneth W. Mahaffey et al. · New England Journal of Medicine | 12 Jun 2017 | 7,908 |
| 3 | Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche Toshiro Sato, Robert G.J. Vries, Hugo J.G. Snippert et al. · Nature | 29 Mar 2009 | 7,361 |
| 4 | AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 Joungmok Kim, Mondira Kundu, Benoı̂t Viollet et al. · Nature Cell Biology | 23 Jan 2011 | 7,286 |
| 5 | Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction John J.V. McMurray et al. · New England Journal of Medicine | 19 Sep 2019 | 7,135 |
| 6 | Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes Stephen D. Wiviott, Itamar Raz, Marc P. Bonaca et al. · New England Journal of Medicine | 10 Nov 2018 | 6,466 |
| 7 | Signal integration in the endoplasmic reticulum unfolded protein response David Ron, Peter Walter · Nature Reviews Molecular Cell Biology | 14 Jun 2007 | 6,391 |
| 8 | Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy Vlado Perkovic et al. · New England Journal of Medicine | 14 Apr 2019 | 6,216 |
| 9 | Inositol trisphosphate, a novel second messenger in cellular signal transduction Michael John Berridge, Robin F. Irvine · Nature | Nov 1984 | 6,133 |
| 10 | Mechanisms linking obesity to insulin resistance and type 2 diabetes Steven E. Kahn, Rebecca L. Hull, Kristina M. Utzschneider · Nature | Dec 2006 | 5,508 |
| 11 | Role of AMP-activated protein kinase in mechanism of metformin action Gaochao Zhou, Robert P. Myers, Ying Li et al. · Journal of Clinical Investigation | 15 Oct 2001 | 5,473 |
| 12 | The Pathobiology of Diabetic Complications Michael Brownlee · Diabetes | Jun 2005 | 5,356 |
| 13 | Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen A.M. James Shapiro, Jonathan R.T. Lakey, Edmond A. Ryan et al. · New England Journal of Medicine | 27 Jul 2000 | 5,299 |
| 14 | Structure of a cannabinoid receptor and functional expression of the cloned cDNA Lisa A. Matsuda, Stephen J. Lolait, Michael Brownstein et al. · Nature | 9 Aug 1990 | 5,040 |
| 15 | Empagliflozin in Heart Failure with a Preserved Ejection Fraction Stefan D. Anker et al. · New England Journal of Medicine | 27 Aug 2021 | 4,854 |
| 16 | Hydrogels for biomedical applications Allan S. Hoffman · Advanced Drug Delivery Reviews | 2002 | 4,833 |
| 17 | AMPK: a nutrient and energy sensor that maintains energy homeostasis David Grahame Hardie, Fiona A. Ross, Simon A. Hawley · Nature Reviews Molecular Cell Biology | 22 Mar 2012 | 4,622 |
| 18 | Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene Jeffrey L. Halaas, K.S. Gajiwala, Margherita Maffei et al. · Science | 28 Jul 1995 | 4,468 |
| 19 | The unfolded protein response: controlling cell fate decisions under ER stress and beyond Claudio A. Hetz · Nature Reviews Molecular Cell Biology | 18 Jan 2012 | 4,252 |
| 20 | AMPK: guardian of metabolism and mitochondrial homeostasis Sébastien Herzig, Reuben J. Shaw · Nature Reviews Molecular Cell Biology | 4 Oct 2017 | 4,189 |
| 21 | β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes Alexandra E. Butler, Juliette Janson, Susan Bonner‐Weir et al. · Diabetes | 2003 | 4,026 |
| 22 | Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range Tadej Battelino et al. · Diabetes Care | 8 Jun 2019 | 4,012 |
| 23 | The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes Daniel J. Drucker, Michael Albrecht Nauck · The Lancet | Nov 2006 | 3,921 |
| 24 | Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes Umut Özcan, Qiong Cao, Erkan Yılmaz et al. · Science | 14 Oct 2004 | 3,878 |
| 25 | Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes Christoph Wanner, Silvio E. Inzucchi, John M. Lachin et al. · New England Journal of Medicine | 14 Jun 2016 | 3,685 |
| 26 | Biology of Incretins: GLP-1 and GIP Laurie L. Baggio, Daniel J. Drucker · Gastroenterology | May 2007 | 3,643 |
| 27 | Mechanisms of fatty acid-induced inhibition of glucose uptake. G Boden, X Chen, J Ruiz et al. · Journal of Clinical Investigation | Jun 1994 | 3,479 |
| 28 | Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression Kenneth R. Watterson, Dawn Bestow, Jennifer R. Gallagher et al. · Neurosignals | 28 Mar 2012 | 3,395 |
| 29 | The Physiology of Glucagon-like Peptide 1 Jens Juul Holst · Physiological Reviews | Oct 2007 | 3,354 |
| 30 | Pathophysiology of Type 2 Diabetes Mellitus Unai Galicia-García, Asier Benito‐Vicente, Shifa Jebari et al. · International Journal of Molecular Sciences | 30 Aug 2020 | 3,331 |
| 31 | Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate Patrick S. Ward, Craig B. Thompson · Cancer Cell | Mar 2012 | 3,326 |
| 32 | From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus Ralph Anthony DeFronzo · Diabetes | 31 Mar 2009 | 3,063 |
| 33 | THE MAMMALIAN UNFOLDED PROTEIN RESPONSE Martin Schröder, Randal J. Kaufman · Annual Review of Biochemistry | Jun 2005 | 3,058 |
| 34 | Physical Activity/Exercise and Diabetes: A Position Statement of the American Diabetes Association Sheri R. Colberg, Ronald J. Sigal, Jane Elizabeth Yardley et al. · Diabetes Care | 11 Oct 2016 | 3,003 |
| 35 | The AMPK signalling pathway coordinates cell growth, autophagy and metabolism Maria M. Mihaylova, Reuben J. Shaw · Nature Cell Biology | Sep 2011 | 2,979 |
| 36 | Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors Raphael Mechoulam, Shimon Ben‐Shabat, Lumir Ondrej Hanus et al. · Biochemical Pharmacology | Jun 1995 | 2,927 |
| 37 | The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas Tomasz Szkudelski · Physiological Research | 2001 | 2,884 |
| 38 | SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials Thomas A. Zelniker, Stephen D. Wiviott, Itamar Raz et al. · The Lancet | 10 Nov 2018 | 2,882 |
| 39 | The role of autophagy during the early neonatal starvation period Akiko Kuma, Masahiko Hatano, Makoto Matsui et al. · Nature | 3 Nov 2004 | 2,878 |
| 40 | Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease Gökhan S. Hotamışlıgil · Cell | Mar 2010 | 2,819 |
| 41 | AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism Barbara B. Kahn, Thierry Alquier, David Carling et al. · Cell Metabolism | 2005 | 2,811 |
| 42 | Trends in GPCR drug discovery: new agents, targets and indications Alexander S. Hauser, Misty M. Attwood, Mathias Rask‐Andersen et al. · Nature Reviews Drug Discovery | 27 Oct 2017 | 2,779 |
| 43 | Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas Paul E. Lacy, Mery Kostianovsky · Diabetes | 1967 | 2,779 |
| 44 | Fetal and infant growth and impaired glucose tolerance at age 64. Charles Nicholas Hales, David J. Barker, Patricia M. Clark et al. · BMJ | 26 Oct 1991 | 2,746 |
| 45 | Mechanisms, regulation and functions of the unfolded protein response Claudio Hetz, Kezhong Zhang, Randal J. Kaufman · Nature Reviews Molecular Cell Biology | 26 May 2020 | 2,740 |
| 46 | Type 1 diabetes Mark A. Atkinson, George S. Eisenbarth, Aaron W. Michels · The Lancet | 25 Jul 2013 | 2,699 |
| 47 | Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress Ira A. Tabas, David Ron · Nature Cell Biology | Mar 2011 | 2,661 |
| 48 | Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy Daniel F. Egan, David B. Shackelford, Maria M. Mihaylova et al. · Science | 23 Dec 2010 | 2,636 |
| 49 | Type 2 diabetes Sudesna Chatterjee, Kamlesh K. Khunti, Melanie J. Davies · The Lancet | 9 Feb 2017 | 2,534 |
| 50 | Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse Sunil R. Hingorani, Emanuel F. Petricoin, Anirban Maitra et al. · Cancer Cell | Dec 2003 | 2,531 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.