Most cited papers in Pharmacogenetics and Drug Metabolism
What are the most cited papers in Pharmacogenetics and Drug Metabolism?
The most cited paper in Pharmacogenetics and Drug Metabolism is "SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules" (Antoine Daina, Olivier Alain Michielin, Vincent Zoete, 2017), with 18,169 citations. Next come "The Carbon Monoxide-binding Pigment of Liver Microsomes" (11,871) and "Arzneimittelforschung" (9,404).
Showing 50 of 99 papers. Every paper with more than 1,247 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules Antoine Daina, Olivier Alain Michielin, Vincent Zoete · Scientific Reports | 3 Mar 2017 | 18,169 |
| 2 | The Carbon Monoxide-binding Pigment of Liver Microsomes Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry | Jul 1964 | 11,871 |
| 3 | Arzneimittelforschung Barbara Miletzki, C. H. Gleiter · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz | Apr 2005 | 9,404 |
| 4 | DrugBank 5.0: a major update to the DrugBank database for 2018 David Scott Wishart et al. · Nucleic Acids Research | 4 Nov 2017 | 9,014 |
| 5 | Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs John Robert Vane · Nature New Biology | Jun 1971 | 8,642 |
| 6 | Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors Ting‐Chao Chou, Paul Talalay · Advances in Enzyme Regulation | 1984 | 7,270 |
| 7 | Drug repurposing: progress, challenges and recommendations Sudeep P. Pushpakom, Francesco Iorio, Patrick A. Eyers et al. · Nature Reviews Drug Discovery | 12 Oct 2018 | 4,863 |
| 8 | Network pharmacology: the next paradigm in drug discovery Andrew L. Hopkins · Nature Chemical Biology | 20 Oct 2008 | 4,644 |
| 9 | Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation Ulrich M. Zanger, Matthias Georg Schwab · Pharmacology & Therapeutics | 16 Jan 2013 | 4,202 |
| 10 | Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue C. De Duve, Berton C. Pressman, R. Gianetto et al. · Biochemical Journal | Aug 1955 | 4,175 |
| 11 | The determination of enzyme inhibitor constants Martin Dixon · Biochemical Journal | Aug 1953 | 4,083 |
| 12 | DrugBank: a comprehensive resource for in silico drug discovery and exploration David Scott Wishart · Nucleic Acids Research | 28 Dec 2005 | 4,078 |
| 13 | Drug-like properties and the causes of poor solubility and poor permeability Christopher A. Lipinski · Journal of Pharmacological and Toxicological Methods | Jul 2000 | 3,766 |
| 14 | Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews | 12 Sep 2012 | 3,761 |
| 15 | The Many Roles for Fluorine in Medicinal Chemistry William K. Hagmann · Journal of Medicinal Chemistry | 21 Jun 2008 | 3,617 |
| 16 | Statistical estimations in enzyme kinetics GN Wilkinson · Biochemical Journal | Aug 1961 | 3,569 |
| 17 | The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I John David Hayes, David J. Pulford · Critical Reviews in Biochemistry and Molecular Biology | 1995 | 3,487 |
| 18 | DrugBank: a knowledgebase for drugs, drug actions and drug targets David Scott Wishart, Craig Knox, An Chi Guo et al. · Nucleic Acids Research | 29 Nov 2007 | 2,956 |
| 19 | ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties Guo‐Li Xiong, Zhenhua Wu, Jiacai Yi et al. · Nucleic Acids Research | 30 Mar 2021 | 2,880 |
| 20 | Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics | Jul 1994 | 2,793 |
| 21 | The NCI60 human tumour cell line anticancer drug screen Robert H. Shoemaker · Nature reviews. Cancer | 22 Sep 2006 | 2,696 |
| 22 | Mechanisms of Cancer Drug Resistance Michael M. Gottesman · Annual Review of Medicine | Feb 2002 | 2,665 |
| 23 | Rings in Drugs Richard D. Taylor, Malcolm MacCoss, Alastair D. G. Lawson · Journal of Medicinal Chemistry | 28 Jan 2014 | 2,540 |
| 24 | Rapid analysis of amino acids using pre-column derivatization Brian A. Bidlingmeyer, Steven A. Cohen, Thomas L. Tarvin · Journal of Chromatography B Biomedical Sciences and Applications | Dec 1984 | 2,524 |
| 25 | Cyclooxygenase in biology and disease Raymond N. DuBois, Steven B. Abramson, Leslie J. Crofford et al. · The FASEB Journal | Sep 1998 | 2,519 |
| 26 | Cytochrome P-450 Polymorphisms and Response to Clopidogrel Jessica L. Mega, Sandra L. Close, Stephen D. Wiviott et al. · New England Journal of Medicine | 22 Dec 2008 | 2,503 |
| 27 | Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics William Edward Evans, Mary V. Relling · Science | 15 Oct 1999 | 2,498 |
| 28 | The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders Walter L. Miller, Richard Joseph Auchus · Endocrine Reviews | Feb 2011 | 2,485 |
| 29 | Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes Bernard Meunier, Sam P. de Visser, Sason S. Shaik · Chemical Reviews | 21 Aug 2004 | 2,420 |
| 30 | The influence of drug-like concepts on decision-making in medicinal chemistry Paul D. Leeson, Brian Springthorpe · Nature Reviews Drug Discovery | 31 Oct 2007 | 2,354 |
| 31 | Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection Bruce N. Ames, William E. Durston, Edith F. Yamasaki et al. · Proceedings of the National Academy of Sciences | Aug 1973 | 2,296 |
| 32 | Computational Methods in Drug Discovery Gregory R. Sliwoski, Sandeepkumar Kothiwale, Jens Meiler et al. · Pharmacological Reviews | 31 Dec 2013 | 2,236 |
| 33 | Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression Peter M. Kuehl, Jiong Zhang, Yvonne Lin et al. · Nature Genetics | Apr 2001 | 2,173 |
| 34 | Pharmacology and Management of the Vitamin K Antagonists Jack Ansell, Jack Hirsh, Elaine M. Hylek et al. · CHEST Journal | Jun 2008 | 2,121 |
| 35 | Structure and Chemistry of Cytochrome P450 Ilia G. Denisov, Thomas M. Makris, Stephen G. Sligar et al. · Chemical Reviews | 21 Apr 2005 | 2,095 |
| 36 | Mechanisms of Estrogen Action Stefan V. Nilsson, Sari Mäkelä, Eckardt Treuter et al. · Physiological Reviews | 10 Jan 2001 | 2,003 |
| 37 | Gastrointestinal Toxicity of Nonsteroidal Antiinflammatory Drugs M. Michael Wolfe, David R. Lichtenstein, Gurkirpal Singh · New England Journal of Medicine | 17 Jun 1999 | 1,963 |
| 38 | A REVISION OF THE SCHOENHEIMER-SPERRY METHOD FOR CHOLESTEROL DETERMINATION Warren M. Sperry, Merrill Webb · Journal of Biological Chemistry | Nov 1950 | 1,936 |
| 39 | Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective Samik Bindu, Somnath Mazumder, Uday Bandyopadhyay · Biochemical Pharmacology | 9 Jul 2020 | 1,935 |
| 40 | A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis Bryan J. Goodwin, Stacey A. Jones, Roger R. Price et al. · Molecular Cell | Sep 2000 | 1,931 |
| 41 | Age‐related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications Arduino Aleksander Mangoni, Stephen H. Jackson · British Journal of Clinical Pharmacology | 16 Dec 2003 | 1,892 |
| 42 | A physiological approach to hepatic drug clearance Grant R. Wilkinson, David G. Shand · Clinical Pharmacology & Therapeutics | Oct 1975 | 1,889 |
| 43 | ADMET in silico modelling: towards prediction paradise? H. Van De Waterbeemd, Eric Gifford · Nature Reviews Drug Discovery | 28 Feb 2003 | 1,882 |
| 44 | DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs Craig Knox, Vivian Law, Timothy Jewison et al. · Nucleic Acids Research | 8 Nov 2010 | 1,870 |
| 45 | Pharmacogenomics Knowledge for Personalized Medicine Michelle Whirl‐Carrillo, Ellen M. McDonagh, Joan M. Hebert et al. · Clinical Pharmacology & Therapeutics | 19 Sep 2012 | 1,865 |
| 46 | Ligand efficiency: a useful metric for lead selection Andrew L. Hopkins, Colin R. Groom, Alexander Alex · Drug Discovery Today | 23 Apr 2004 | 1,857 |
| 47 | The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. R Tenhunen, Harvey S. Marver, Roman Schmid · Proceedings of the National Academy of Sciences | Oct 1968 | 1,815 |
| 48 | The support of human genetic evidence for approved drug indications Matthew R. Nelson, Hannah Tipney, Jeffery L. Painter et al. · Nature Genetics | 29 Jun 2015 | 1,812 |
| 49 | Hepatotoxicity and Mechanism of Action of Haloalkanes: Carbon Tetrachloride as a Toxicological Model Lutz W. D. Weber, Meinrad Boll, Andreas Stampfl · Critical Reviews in Toxicology | 2003 | 1,783 |
| 50 | Pharmacogenomics — Drug Disposition, Drug Targets, and Side Effects William Edward Evans, Howard L. McLeod · New England Journal of Medicine | 5 Feb 2003 | 1,777 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.