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Topic · Pharmacology

Pharmacogenetics and Drug Metabolism

Pharmacogenetics and Drug Metabolism is a research topic within Pharmacology. Science Explorer counts 44k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the study of drug metabolism, particularly the role of Cytochrome P450 enzymes, genetic variations impacting enzyme activities, pharmacogenetics, personalized medicine, and the influence of polymorphisms on drug response and pharmacokinetics. It also explores the impact of these factors on warfarin dose estimation and xenobiotic metabolism.

  • Cytochrome P450
  • Pharmacogenetics
  • Drug Metabolism
  • Genetic Variation
  • Enzyme Activities
  • Pharmacokinetics
  • Polymorphisms
  • Personalized Medicine
  • Warfarin Dose
  • Xenobiotic Metabolism
Research works
44k
fractional, since 1950
In the world top 10%
4.4k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
0%
the tick is no change
Largest producer
United States
34% of the 10 largest, 2022-now
Pharmacogenetics and Drug Metabolism

Which countries lead Pharmacogenetics and Drug Metabolism research?

By volume, the United States and China publish the most (1.2k and 826 works in 2022-now).

By volume, 2022-now

  1. 1 United States 1.2k works
  2. 2 China 826 works
  3. 3 India 324 works
  4. 4 Japan 222 works
  5. 5 United Kingdom 206 works
  6. 6 Germany 194 works
  7. 7 Canada 121 works
  8. 8 South Korea 114 works
  9. 9 France 106 works
  10. 10 Italy 103 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 34.4%China: 24.5%India: 9.6%Japan: 6.6%6 others listed: 25.0%34%largest
United States1,159 · 34.4%China826 · 24.5%India324 · 9.6%Japan222 · 6.6%6 others listed843 · 25.0%

Shares of the rows listed above, not of the whole node.

Which institutions lead Pharmacogenetics and Drug Metabolism research?

By volume in 2022-now, Pfizer (United States) publishes the most Pharmacogenetics and Drug Metabolism research, followed by Chinese Academy of Sciences and Russian Academy of Sciences.

By volume, 2022-now

  1. 1 Pfizer (United States)United States 29 works
  2. 2 Chinese Academy of SciencesChina 29 works
  3. 3 Russian Academy of SciencesRussia 28 works
  4. 4 University of North Carolina at Chapel HillUnited States 25 works
  5. 5 United States Food and Drug AdministrationUnited States 25 works
  6. 6 University of MichiganUnited States 23 works
  7. 7 University of TorontoCanada 21 works
  8. 8 Harvard UniversityUnited States 21 works
  9. 9 National Institutes of HealthUnited States 20 works
  10. 10 InsermFrance 20 works

Who are the leading researchers in Pharmacogenetics and Drug Metabolism?

The most-cited researchers publishing on Pharmacogenetics and Drug Metabolism include George Davey Smith, Walter Churchill Willett and Mark J. Daly.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Walter Churchill Willett United States 411k citations
  3. 3 Mark J. Daly United States 403k citations
  4. 4 Peer Bork Germany 396k citations
  5. 5 Elaine R. Mardis United States 346k citations
  6. 6 Hermann Brenner Germany 343k citations
  7. 7 Giuseppe Remuzzi Italy 328k citations
  8. 8 John P. A. Ioannidis United States 317k citations
  9. 9 Gregory Y.H. Lip United Kingdom 311k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Pharmacogenetics and Drug Metabolism?

The most cited paper in Pharmacogenetics and Drug Metabolism is "SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules" (Antoine Daina, Olivier Alain Michielin, Vincent Zoete, 2017), with 18,169 citations. Next come "The Carbon Monoxide-binding Pigment of Liver Microsomes" (11,871) and "Arzneimittelforschung" (9,404).

Most cited papers
#PaperReleasedCitations
1 SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules Antoine Daina, Olivier Alain Michielin, Vincent Zoete · Scientific Reports Open access 3 Mar 2017 18,169
2 The Carbon Monoxide-binding Pigment of Liver Microsomes Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry Open access Jul 1964 11,871
3 Arzneimittelforschung Barbara Miletzki, C. H. Gleiter · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz Apr 2005 9,404
4 DrugBank 5.0: a major update to the DrugBank database for 2018 David Scott Wishart et al. · Nucleic Acids Research Open access 4 Nov 2017 9,014
5 Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs John Robert Vane · Nature New Biology Jun 1971 8,642
All 99 most cited papers, with filters and sorting

Where is Pharmacogenetics and Drug Metabolism research done?

The largest centres of Pharmacogenetics and Drug Metabolism research in 2022-now are Beijing (China), Shanghai (China), Tokyo (Japan) and New York (United States). Among places with at least 20 works in it, it is an unusually large share of all research in Silver Spring.

Largest cities, 2022-now

  1. 1 BeijingChina 115 works
  2. 2 ShanghaiChina 75 works
  3. 3 TokyoJapan 71 works
  4. 4 New YorkUnited States 58 works
  5. 5 LondonUnited Kingdom 54 works
  6. 6 MoscowRussia 51 works
  7. 7 SeoulSouth Korea 50 works
  8. 8 GuangzhouChina 48 works
  9. 9 HangzhouChina 44 works
  10. 10 ParisFrance 43 works

Where it is the local speciality

  1. Silver SpringUS · 20.8 works20×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Pharmacogenetics and Drug Metabolism than the world average.

See Pharmacogenetics and Drug Metabolism on the map

Where is the best place to study Pharmacogenetics and Drug Metabolism?

Among universities, judged by research, Vanderbilt University, Karolinska Institutet and University of Michigan score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 14.99%fractional works in this field (log) →share of work in the world top 10% →Karolinska InstitutetVanderbilt UniversityUniversity of MichiganHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Vanderbilt UniversityUnited States 73.017.7%6.5×20 -28.7%
2Karolinska InstitutetSweden 64.919.3%5.8×14 -32.1%
3University of MichiganUnited States 62.911.6%3.6×23 -10.4%
4Harvard UniversityUnited States 62.111.4%1.6×21 +0.5%
5Washington State UniversityUnited States 61.912.6%12.0×17 +26.1%
6University of ManchesterUnited Kingdom 60.418.3%3.5×12 -14.7%
7University of CincinnatiUnited States 58.818.3%4.7×12 +17.2%
8King Saud UniversitySaudi Arabia 57.616.6%3.0×12 +42.8%
9University of WashingtonUnited States 56.714.6%3.6×17 -39.2%
10University of TorontoCanada 55.49.5%2.5×21 -15.1%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Pharmacogenetics and Drug Metabolism, country by country

Is Pharmacogenetics and Drug Metabolism research growing?

Output in 2022-2025 was 0% lower than in 2018-2021, peaking in 2013.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Pharmacogenetics and Drug Metabolism as a percentage of every work published that year, 0.019% in 2024.

still counting0.050%0.10%0.15%Pharmacogenetics and Drug Metabolism0.020% in 202519801990200020102020

Fractional works of Pharmacogenetics and Drug Metabolism over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Pharmacogenetics and Drug Metabolism10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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