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Topic · Pharmacology

Alkaloids: synthesis and pharmacology

Alkaloids: synthesis and pharmacology is a research topic within Pharmacology. Science Explorer counts 12k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the pharmacology, synthesis, and effects of kratom alkaloids, particularly those derived from Mitragyna speciosa. It covers topics such as opioid withdrawal, neuropharmacological effects, total synthesis of alkaloids, traditional medicine usage, and toxicological studies.

  • Kratom
  • Alkaloids
  • Mitragyna Speciosa
  • Opioid Withdrawal
  • Indole Alkaloids
  • Total Synthesis
  • Pharmacological Effects
  • Traditional Medicine
  • Neuropharmacology
  • Toxicology
Research works
12k
fractional, since 1950
In the world top 10%
1.2k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+11%
the tick is no change
Largest producer
China
42% of the 10 largest, 2022-now
Alkaloids: synthesis and pharmacology

Which countries lead Alkaloids: synthesis and pharmacology research?

By volume, China and the United States publish the most (640 and 276 works in 2022-now).

By volume, 2022-now

  1. 1 China 640 works
  2. 2 United States 276 works
  3. 3 India 174 works
  4. 4 Indonesia 110 works
  5. 5 Japan 105 works
  6. 6 Brazil 49 works
  7. 7 Germany 47 works
  8. 8 Thailand 42 works
  9. 9 France 41 works
  10. 10 Malaysia 37 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 42.0%United States: 18.2%India: 11.4%Indonesia: 7.2%6 others listed: 21.1%42%largest
China640 · 42.0%United States276 · 18.2%India174 · 11.4%Indonesia110 · 7.2%6 others listed322 · 21.1%

Shares of the rows listed above, not of the whole node.

Which institutions lead Alkaloids: synthesis and pharmacology research?

By volume in 2022-now, Chinese Academy of Sciences publishes the most Alkaloids: synthesis and pharmacology research, followed by Chinese Academy of Medical Sciences & Peking Union Medical College and University of Florida.

By volume, 2022-now

  1. 1 Chinese Academy of SciencesChina 49 works
  2. 2 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 16 works
  3. 3 University of FloridaUnited States 16 works
  4. 4 Centre National de la Recherche ScientifiqueFrance 16 works
  5. 5 Andalas UniversityIndonesia 14 works
  6. 6 Universiti Sains MalaysiaMalaysia 14 works
  7. 7 Russian Academy of SciencesRussia 13 works
  8. 8 Sichuan UniversityChina 11 works
  9. 9 Council of Scientific and Industrial ResearchIndia 10 works
  10. 10 Tanjungpura UniversityIndonesia 9 works

Who are the leading researchers in Alkaloids: synthesis and pharmacology?

The most-cited researchers publishing on Alkaloids: synthesis and pharmacology include Dan J. Stein, Amirhossein Sahebkar and Stefan Grimme.

  1. 1 Dan J. Stein South Africa 306k citations
  2. 2 Amirhossein Sahebkar Iran 258k citations
  3. 3 Stefan Grimme Germany 224k citations
  4. 4 Trevor William Robbins United Kingdom 199k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Alkaloids: synthesis and pharmacology?

The most cited paper in Alkaloids: synthesis and pharmacology is "Proline-Catalyzed Direct Asymmetric Aldol Reactions" (Benjamin List, Richard Alan Lerner, Carlos F. Barbas, 2000), with 2,868 citations. Next come "Qinghaosu (Artemisinin): an Antimalarial Drug from China" (2,188) and "New Strategies for Organic Catalysis: The First Highly Enantioselective Organocatalytic Diels−Alder Reaction" (1,690).

Most cited papers
#PaperReleasedCitations
1 Proline-Catalyzed Direct Asymmetric Aldol Reactions Benjamin List, Richard Alan Lerner, Carlos F. Barbas · Journal of the American Chemical Society 26 Feb 2000 2,868
2 Qinghaosu (Artemisinin): an Antimalarial Drug from China Daniel L. Klayman · Science 31 May 1985 2,188
3 New Strategies for Organic Catalysis: The First Highly Enantioselective Organocatalytic Diels−Alder Reaction Kateri A. Ahrendt, Christopher J. Borths, David W. C. MacMillan · Journal of the American Chemical Society 15 Apr 2000 1,690
4 Aerobic Copper-Catalyzed Organic Reactions Scott E. Allen, Ryan R. Walvoord, Rosaura Padilla‐Salinas et al. · Chemical Reviews ReviewOpen access 20 Jun 2013 1,623
5 Construction of Spiro[pyrrolidine‐3,3′‐oxindoles] − Recent Applications to the Synthesis of Oxindole Alkaloids Christiane Marti, Erick M. Carreira · European Journal of Organic Chemistry Jun 2003 1,454
All 100 most cited papers, with filters and sorting

Where is Alkaloids: synthesis and pharmacology research done?

The largest centres of Alkaloids: synthesis and pharmacology research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Kunming (China). Among places with at least 20 works in it, it is an unusually large share of all research in Kunming.

Largest cities, 2022-now

  1. 1 BeijingChina 89 works
  2. 2 ShanghaiChina 42 works
  3. 3 GuangzhouChina 34 works
  4. 4 KunmingChina 32 works
  5. 5 TokyoJapan 30 works
  6. 6 ChengduChina 27 works
  7. 7 NanjingChina 23 works
  8. 8 ChangshaChina 19 works
  9. 9 JinanChina 18 works
  10. 10 PadangIndonesia 17 works

Where it is the local speciality

  1. KunmingCN · 32.0 works7.4×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Alkaloids: synthesis and pharmacology than the world average.

See Alkaloids: synthesis and pharmacology on the map

Where is the best place to study Alkaloids: synthesis and pharmacology?

Among universities, judged by research, University of Florida, Chinese Academy of Medical Sciences & Peking Union Medical College and Universiti Sains Malaysia score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 8.34%fractional works in this field (log) →share of work in the world top 10% →China Pharmaceutical…University of FloridaChinese Academy of M…Universiti Sains Mal…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1University of FloridaUnited States 94.016.4%8.4×16 +32.1%
2Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 68.910.0%8.6×16 -8.5%
3Universiti Sains MalaysiaMalaysia 68.16.0%11.5×14 -2.9%
4China Pharmaceutical UniversityChina 49.820.5%20.6×8 +1.5%
5Prince of Songkla UniversityThailand 48.17.1%20.8×8 +641.7%
6Andalas UniversityIndonesia 47.52.4%15.1×14 +59.9%
7Chiba UniversityJapan 42.65.4%18.4×9 +69.3%
8Sichuan UniversityChina 38.69.9%2.6×11 -13.5%
9Hunan Agricultural UniversityChina 37.45.7%30.9×8 +15.2%
10Tanjungpura UniversityIndonesia 22.00.0%9.9×9 +188.4%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Alkaloids: synthesis and pharmacology, country by country

Is Alkaloids: synthesis and pharmacology research growing?

Output in 2022-2025 was 11% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Alkaloids: synthesis and pharmacology.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Alkaloids: synthesis and pharmacology as a percentage of every work published that year, 0.0079% in 2024.

still counting0.010%0.020%Alkaloids: synthesis and pharmacology0.0087% in 202519801990200020102020

Fractional works of Alkaloids: synthesis and pharmacology over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Alkaloids: synthesis and pharmacology10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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