Most cited papers in Pharmacological Effects and Toxicity Studies
What are the most cited papers in Pharmacological Effects and Toxicity Studies?
The most cited paper in Pharmacological Effects and Toxicity Studies is "ILAE Official Report: A practical clinical definition of epilepsy" (Robert S. Fisher, Carlos Alberto Acevedo, Alexis A. Arzimanoglou et al., 2014), with 6,110 citations. Next come "Early Identification of Refractory Epilepsy" (5,229) and "ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology" (5,051).
Showing 50 of 100 papers. Every paper with more than 939 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | ILAE Official Report: A practical clinical definition of epilepsy Robert S. Fisher, Carlos Alberto Acevedo, Alexis A. Arzimanoglou et al. · Epilepsia | Apr 2014 | 6,110 |
| 2 | Early Identification of Refractory Epilepsy Patrick Kwan, Martin J. Brodie · New England Journal of Medicine | 3 Feb 2000 | 5,229 |
| 3 | ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology Ingrid Eileen Scheffer, Samuel Frank Berkovic, Giuseppe Capovilla et al. · Epilepsia | 8 Mar 2017 | 5,051 |
| 4 | Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies Patrick Kwan, Alexis A. Arzimanoglou, Anne T. Berg et al. · Epilepsia | 3 Nov 2009 | 4,888 |
| 5 | An estimate of the worldwide prevalence and disability associated with osteoporotic fractures Olof Johnell, John A. Kanis · Osteoporosis International | 15 Sep 2006 | 4,765 |
| 6 | Incidence and Economic Burden of Osteoporosis-Related Fractures in the United States, 2005–2025 Russel Thomas Burge, Bess Dawson‐Hughes, Daniel H. Solomon et al. · Journal of Bone and Mineral Research | 4 Dec 2006 | 4,070 |
| 7 | Epileptic Seizures and Epilepsy: Definitions Proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE) Robert S. Fisher, W. van Emde Boas, Warren T. Blume et al. · Epilepsia | 29 Mar 2005 | 3,682 |
| 8 | A Randomized Controlled Trial of Surgery for Temporal Lobe Epilepsy Samuel Wiebe, Warren T. Blume, John P. Girvin et al. · New England Journal of Medicine | 2 Aug 2001 | 3,547 |
| 9 | Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology Robert S. Fisher, Judith Helen Cross, Jacqueline A. French et al. · Epilepsia | 8 Mar 2017 | 3,494 |
| 10 | Occurrence of drugs in German sewage treatment plants and rivers Thomas A. Ternes · Water Research | Nov 1998 | 3,419 |
| 11 | Membrane transporters in drug development Kathleen M. Giacomini et al. · Nature Reviews Drug Discovery | Mar 2010 | 3,373 |
| 12 | Surgical Treatment of the Epilepsies Prakash Kotagal · Journal of Clinical Neurophysiology | Jul 1994 | 2,759 |
| 13 | Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis Geoffrey A. Block, Preston Klassen, J. Michael Lazarus et al. · Journal of the American Society of Nephrology | Aug 2004 | 2,697 |
| 14 | Osteoporosis in the European Union: medical management, epidemiology and economic burden Emma Hernlund, A Svedbom, Moa Ivergård et al. · Archives of Osteoporosis | 11 Oct 2013 | 2,679 |
| 15 | A definition and classification of status epilepticus – Report of the ILAE Task Force on Classification of Status Epilepticus Eugen Trinka, Hannah R. Cock, Dale C. Hesdorffer et al. · Epilepsia | 4 Sep 2015 | 2,449 |
| 16 | Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo Sven Hoffmeyer, Oliver Burk, Oliver von Richter et al. · Proceedings of the National Academy of Sciences | 14 Mar 2000 | 2,371 |
| 17 | A multidrug resistance transporter from human MCF-7 breast cancer cells L. Austin Doyle, Weidong Yang, Lynne V. Abruzzo et al. · Proceedings of the National Academy of Sciences | 22 Dec 1998 | 2,333 |
| 18 | Comment on Epileptic Seizures and Epilepsy: Definitions Proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE) Ettore Beghi, Anne T. Berg, Arturo Carpio et al. · Epilepsia | 28 Sep 2005 | 2,314 |
| 19 | Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell | May 1994 | 2,298 |
| 20 | A Proposed Diagnostic Scheme for People with Epileptic Seizures and with Epilepsy: Report of the ILAE Task Force on Classification and Terminology Jerome P. Engel · Epilepsia | Jun 2001 | 2,256 |
| 21 | Incidence of Epilepsy and Unprovoked Seizures in Rochester, Minnesota: 1935–1984 W. Allen Hauser, John Fred Annegers, Leonard T. Kurland · Epilepsia | May 1993 | 2,087 |
| 22 | The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials Heiner C. Bucher, Gordon Henry Guyatt, Lauren E. Griffith et al. · Journal of Clinical Epidemiology | Jun 1997 | 2,085 |
| 23 | Prevalence and incidence of epilepsy Kirsten Marie Fiest, Khara M. Sauro, Samuel Wiebe et al. · Neurology | 17 Dec 2016 | 1,910 |
| 24 | Revisiting the role of ABC transporters in multidrug-resistant cancer Robert W. Robey, Kristen M. Pluchino, Matthew D. Hall et al. · Nature reviews. Cancer | 11 Apr 2018 | 1,890 |
| 25 | Calcium plus Vitamin D Supplementation and the Risk of Fractures Rebecca D. Jackson et al. · New England Journal of Medicine | 15 Feb 2006 | 1,890 |
| 26 | The role of inflammation in epilepsy Annamaria Vezzani, Jacqueline A. French, Tamás Bartfai et al. · Nature Reviews Neurology | 7 Dec 2010 | 1,888 |
| 27 | A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins Piet Borst, Raymond Evers, Marcel Kool et al. · JNCI Journal of the National Cancer Institute | 16 Aug 2000 | 1,766 |
| 28 | Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Carlos Cordon‐Cardo, James P. O’Brien, D Casals et al. · Proceedings of the National Academy of Sciences | 1989 | 1,760 |
| 29 | KDIGO clinical practice guideline for the care of kidney transplant recipients: a summary Bertram L. Kasiske et al. · Kidney International | 21 Oct 2009 | 1,748 |
| 30 | A Note on a Simple Apparatus for Detecting Neurological Deficit in Rats and Mice**College of Pharmacy, University of Nebraska, Lincoln 8. Norris W. Dunham, T.S. Miya · Journal of the American Pharmaceutical Association (Scientific ed ) | Mar 1957 | 1,721 |
| 31 | Bipolar disorder Iría Grande, Michael Berk, Boris B. Birmaher et al. · The Lancet | 18 Sep 2015 | 1,686 |
| 32 | Guidelines for the Evaluation and Management of Status Epilepticus Gretchen M. Brophy, RODNEY D. BELL, Jan Claassen et al. · Neurocritical Care | 23 Apr 2012 | 1,630 |
| 33 | Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs Zhibin ZC Chen, Martin J. Brodie, Danny Liew et al. · JAMA Neurology | 26 Dec 2017 | 1,562 |
| 34 | Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers Ina Hubatsch, Eva Ragnarsson, Per Artursson · Nature Protocols | 23 Aug 2007 | 1,512 |
| 35 | Calcineurin Inhibitor Nephrotoxicity Maarten Naesens, Dirk R. J. Kuypers, Minnie Sarwal · Clinical Journal of the American Society of Nephrology | Feb 2009 | 1,498 |
| 36 | Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease Jasper Smit, Alfred H. Schinkel, Ronald P.J. Oude Elferink et al. · Cell | Nov 1993 | 1,478 |
| 37 | Estimation of the burden of active and life‐time epilepsy: A meta‐analytic approach Anthony K. Ngugi, Christian Bottomley, Immo Kleinschmidt et al. · Epilepsia | 7 Jan 2010 | 1,467 |
| 38 | The Epidemiology of Epilepsy Ettore Beghi · Neuroepidemiology | 18 Dec 2019 | 1,442 |
| 39 | Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense Elaine M. Leslie, Roger G. Deeley, Susan P.C. Cole · Toxicology and Applied Pharmacology | 16 Dec 2004 | 1,426 |
| 40 | Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and Childhood Autism Jakob Christensen, Therese Koops Grønborg, Merete Juul Sørensen et al. · JAMA | 24 Apr 2013 | 1,386 |
| 41 | A Comparison of Four Treatments for Generalized Convulsive Status Epilepticus David M. Treiman, Patti D. Meyers, Nancy Y. Walton et al. · New England Journal of Medicine | 17 Sep 1998 | 1,341 |
| 42 | Palliative Care Cecilia R. Sepulveda, Amanda Marlin, Tokuo Yoshida et al. · Journal of Pain and Symptom Management | Aug 2002 | 1,312 |
| 43 | Experience with the International League Against Epilepsy Proposals for Classification of Epileptic Seizures and the Epilepsies and Epileptic Syndromes in a Pediatric Outpatient Epilepsy Clinic Jorge Eslava‐Cobos, Daniel Naririo · Epilepsia | Feb 1989 | 1,295 |
| 44 | Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society Tracy A. Glauser, Shlomo Shinnar, David S. Gloss et al. · Epiliepsy currents/Epilepsy currents | 2016 | 1,291 |
| 45 | P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. Alfred H. Schinkel, Els Wagenaar, Carla A.A.M. Mol et al. · Journal of Clinical Investigation | Jun 1996 | 1,273 |
| 46 | Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC Augusto Tommaso Caraceni et al. · The Lancet Oncology | 31 Jan 2012 | 1,256 |
| 47 | Early Surgical Therapy for Drug-Resistant Temporal Lobe Epilepsy Jerome Engel · JAMA | 6 Mar 2012 | 1,242 |
| 48 | Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview Alfred H. Schinkel, Johan W. Jonker · Advanced Drug Delivery Reviews | 13 Sep 2012 | 1,233 |
| 49 | Surgical treatment of the epilepsies Stephen M. Bloomfield, Andrew G. Shetter · Surgical Neurology | Mar 1988 | 1,207 |
| 50 | Blood–brain barrier delivery William M. Pardridge · Drug Discovery Today | 14 Nov 2006 | 1,204 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.