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Most cited papers in Phytochemistry and Bioactive Compounds

Phytochemistry and Bioactive Compounds

What are the most cited papers in Phytochemistry and Bioactive Compounds?

The most cited paper in Phytochemistry and Bioactive Compounds is "Interleukin-1 polymorphisms associated with increased risk of gastric cancer" (Emad M. El-Omar, Mary N Carrington, Wong-Ho Chow et al., 2000), with 2,384 citations. Next come "Distribution of Menaquinones in Actinomycetes and Corynebacteria" (2,293) and "Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine" (1,410).

Showing 50 of 100 papers. Every paper with more than 211 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Interleukin-1 polymorphisms associated with increased risk of gastric cancer Emad M. El-Omar, Mary N Carrington, Wong-Ho Chow et al. · Nature 23 Mar 2000 2,384
2 Distribution of Menaquinones in Actinomycetes and Corynebacteria M.D. Collins, T. Pirouz, Michael Goodfellow et al. · Journal of General Microbiology Jun 1977 2,293
3 Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine Michelino Di Rosa, J. P. Giroud, D. A. Willoughby · The Journal of Pathology May 1971 1,410
4 The Therapeutic Potential of Naringenin: A Review of Clinical Trials Bahare Salehi, Patrick Valère Tsouh Fokou, Mehdi Sharifi‐Rad et al. · Pharmaceuticals Open access 10 Jan 2019 819
5 Saponins as cytotoxic agents: a review Irma Podolak, Agnieszka Galanty, Danuta Sobolewska · Phytochemistry Reviews Open access 24 Jun 2010 706
6 Clinical Practice Guidelines for the Management of Sporotrichosis: 2007 Update by the Infectious Diseases Society of America Carol A. Kauffman, Beatriz Bustamante, Stanley W. Chapman et al. · Clinical Infectious Diseases Open access 15 Nov 2007 572
7 Serum and glucocorticoid‐inducible kinase (SGK) is a target of the PI 3‐kinase‐stimulated signaling pathway Jongsun Park, Meredith L.L. Leong, Patricia Buse et al. · The EMBO Journal Open access Jun 1999 560
8 Cardiac Glycosides as Novel Cancer Therapeutic Agents Robert Alan Newman, Pei Yang, Alison D. Pawlus et al. · Molecular Interventions Feb 2008 526
9 A Drug over the Millennia : Pharmacognosy, Chemistry, and Pharmacology of Licorice Shoji SHIBATA · YAKUGAKU ZASSHI Open access 2000 522
10 Chemical and Pharmacological Research of the Plants in Genus Euphorbia Qing‐Wen Shi, Xiao-Hui Su, Hiromasa Kiyota · Chemical Reviews Review 25 Sep 2008 500
11 Toxic cardenolides: chemical ecology and coevolution of specialized plant–herbivore interactions Anurag A. Agrawal, Georg Petschenka, Robin A. Bingham et al. · New Phytologist Open access 31 Jan 2012 489
12 Plant-derived compounds in clinical trials Arvind Saklani, Samuel K. Kutty · Drug Discovery Today Dec 2007 486
13 Potent selective inhibitors of protein kinase C Peter D. Davis, Christopher H. Hill, Elizabeth Keech et al. · FEBS Letters Open access 18 Dec 1989 480
14 Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo Juhua Chen, Payaningal R. Somanath, Olga V. Razorenova et al. · Nature Medicine Open access 16 Oct 2005 463
15 Mucopolysaccharidosis I: Management and Treatment Guidelines Joseph Muenzer, J. E. Wraith, Lorne A. Clarke et al. · PEDIATRICS 29 Dec 2008 462
16 Verbascoside — A review of its occurrence, (bio)synthesis and pharmacological significance Kalina Iv. Alipieva, Liudmila G. Korkina, İlkay Erdoğan Orhan et al. · Biotechnology Advances 15 Jul 2014 461
17 Biological properties of carrageenan Massimo Di Rosa · Journal of Pharmacy and Pharmacology Open access Feb 1972 459
18 Potentiating effect of β-caryophyllene on anticancer activity of α-humulene, isocaryophyllene and paclitaxel Jean Legault, André Pichette · Journal of Pharmacy and Pharmacology 21 Nov 2007 452
19 Biological activity of limonoids from the rutales Donald E. Champagne, Opender Koul, Murray B. Isman et al. · Phytochemistry Feb 1992 450
20 VEGF signalling: integration and multi-tasking in endothelial cell biology Ian C. Zachary · Biochemical Society Transactions Dec 2003 430
21 Mechanisms of action of methotrexate Laurent Genestier, Romain Paillot, Laurence Quéméneur et al. · Immunopharmacology May 2000 427
22 Brefeldin A Pierre Teilhard de Chardin, Frank McCormick · Cell Open access Apr 1999 425
23 Azaphilones: Chemistry and Biology Jin‐Ming Gao, Shengxiang Yang, Jianchun Qin · Chemical Reviews Review 12 Apr 2013 409
24 Anti-Inflammatory Compounds of Plant Origin. Part II. Modulation of Pro-Inflammatory Cytokines, Chemokines and Adhesion Molecules João Β. Calixto, Maria M. Campos, Michel Fleith Otuki et al. · Planta Medica Open access Feb 2004 409
25 Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology Shadma Wahab, Sivakumar Annadurai, Shahabe Saquib Abullais et al. · Plants Open access 14 Dec 2021 399
26 Epidemiology and Diagnosis of H elicobacter pylori infection Andreas F. Mentis, Philippe Lehours, Françis Mégraud · Helicobacter Sep 2015 398
27 Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa Brendan J.R. Whittle, Gerald A Higgs, K.E. Eakins et al. · Nature Mar 1980 396
28 A history of the therapeutic use of liquorice in Europe Cristina Fiore, Michael Eisenhut, Eugenio Ragazzi et al. · Journal of Ethnopharmacology Open access 23 Jun 2005 390
29 Screening of Yemeni medicinal plants for antibacterial and cytotoxic activities Nasser A. Awadh Ali, W.-D. Jülich, C Kusnick et al. · Journal of Ethnopharmacology Feb 2001 384
30 Postmenopausal Estrogen and Prevention Bias Elizabeth L Barrett-Connor · Annals of Internal Medicine 15 Sep 1991 380
31 Exploring the potential of endophytes from medicinal plants as sources of antimycobacterial compounds Alfonsus Alvin, Kristin I. Miller, Brett Anthony Neilan · Microbiological Research Open access 15 Jan 2014 377
32 Best Practice in the chemical characterisation of extracts used in pharmacological and toxicological research—The ConPhyMP—Guidelines12 Michael Heinrich, Banaz Jalil, Mona Abdel‐Tawab et al. · Frontiers in Pharmacology Open access 13 Sep 2022 371
33 Anti-Helicobacter pylori flavonoids from licorice extract Toshio Fukai, Ai Marumo, Kiyoshi Kaitou et al. · Life Sciences Aug 2002 370
34 The carbohydrates of the Jerusalem artichoke and other Compositae John S. D. Bacon, Jack R. Edelman · Biochemical Journal Open access 1951 366
35 Preliminary screening of some traditional zulu medicinal plants for anti-inflammatory and anti-microbial activities Johnson Lin, Andy Rowland Opoku, M. Geheeb-Keller et al. · Journal of Ethnopharmacology Dec 1999 365
36 Colonization of gnotobiotic piglets by Helicobacter pylori deficient in two flagellin genes Kathryn A. Eaton, Sebastian Suerbaum, Christine Josenhans et al. · Infection and Immunity Open access Jul 1996 360
37 Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection Erik De Clercq · Medicinal Research Reviews 2000 358
38 Revisiting the ancient concept of botanical therapeutics Barbara M. Schmidt, David Ribnicky, Peter E. Lipsky et al. · Nature Chemical Biology 19 Jun 2007 358
39 Phytopharmacological overview of Tribulus terrestris Saurabh P. Chhatre, Tanuja Manoj Nesari, Divya M. Kanchan et al. · Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review Open access 2014 356
40 Psoriasis is associated with lipid abnormalities at the onset of skin disease Lotus Mallbris, Fredrik N. Granath, Anders Hamsten et al. · Journal of the American Academy of Dermatology 20 Jan 2006 354
41 Sesquiterpenes from Clove (Eugenia caryophyllata) as Potential Anticarcinogenic Agents Guo-Qiang Zheng, Patrick M. J. Kenney, Luke K. T. Lam · Journal of Natural Products Jul 1992 345
42 Screening of Zulu medicinal plants for prostaglandin-synthesis inhibitors Anna K. Jäger, Anne Hutchings, Johannes van Staden · Journal of Ethnopharmacology Jun 1996 345
43 A broad review of commercially important southern African medicinal plants B.-E. Van Wyk · Journal of Ethnopharmacology 4 Jun 2008 342
44 The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB. Heike Luise Pahl, B Krauss, Klaus Schulze‐Osthoff et al. · The Journal of Experimental Medicine Open access Apr 1996 337
45 Cytotoxic activity screening of some indigenous Thai plants Pokpong Prayong, Sahapat Barusrux, Natthida Weerapreeyakul · Fitoterapia 14 Jul 2008 334
46 Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark Machindra J. Chavan, Pravin Wakte, D. B. Shinde · Phytomedicine 3 Jul 2009 327
47 Chemical Biology of Epothilones Kyriacos Costa Nicolaou, Frank Roschangar, Dionisios Vourloumis · Angewandte Chemie International Edition 17 Aug 1998 325
48 Selectivity of Neutrophil 5-Lipoxygenase and Cyclo-oxygenase Inhibition by an Anti-inflammatory Flavonoid Glycoside and Related Aglycone Flavonoids M.A. Moroney, M. José Alcaraz, Robert A. Forder et al. · Journal of Pharmacy and Pharmacology Nov 1988 324
49 Anti-inflammatory Properties of the Monoterpene 1.8-cineole: Current Evidence for Co-medication in Inflammatory Airway Diseases Uwe R. Juergens · Drug Research 15 May 2014 294
50 Plant profile, phytochemistry and pharmacology of Asparagus racemosus (Shatavari): A review Shashi Alok, Sanjay Jain, Amita Verma et al. · Asian Pacific Journal of Tropical Disease Open access 26 Mar 2013 292

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.