Topic · Pluripotent Stem Cells Research
Most cited papers in Pluripotent Stem Cells Research
What are the most cited papers in Pluripotent Stem Cells Research?
The most cited paper in Pluripotent Stem Cells Research is "Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors" (Kazutoshi Takahashi, Shinya Yamanaka, 2006), with 26,957 citations. Next come "Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors" (20,424) and "Embryonic Stem Cell Lines Derived from Human Blastocysts" (16,067).
Showing 50 of 99 papers. Every paper with more than 1,928 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors Kazutoshi Takahashi, Shinya Yamanaka · Cell | Aug 2006 | 26,957 |
| 2 | Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki et al. · Cell | Nov 2007 | 20,424 |
| 3 | Embryonic Stem Cell Lines Derived from Human Blastocysts James Alexander Thomson, Joseph Itskovitz‐Eldor, Sander S. Shapiro et al. · Science | 6 Nov 1998 | 16,067 |
| 4 | Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Andrew Z. Fire, Siqun Xu, Mary Katherine Montgomery et al. · Nature | Feb 1998 | 15,508 |
| 5 | Matrix Elasticity Directs Stem Cell Lineage Specification Adam Jeffrey Engler, Shamik Sen, Hugh Lee Sweeney et al. · Cell | Aug 2006 | 13,994 |
| 6 | Stages of embryonic development of the zebrafish Charles B. Kimmel, William Whitney Ballard, Seth R. Kimmel et al. · Developmental Dynamics | Jul 1995 | 12,479 |
| 7 | Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells Junying Yu, Maxim A. Vodyanik, Kim Smuga-Otto et al. · Science | 20 Nov 2007 | 10,385 |
| 8 | Establishment in culture of pluripotential cells from mouse embryos Martin John Evans, M. H. Kaufman · Nature | Jul 1981 | 8,657 |
| 9 | 3D bioprinting of tissues and organs Sean V. Murphy, Anthony Atala · Nature Biotechnology | Aug 2014 | 7,011 |
| 10 | Mesenchymal stem cells Arnold I. Caplan · Journal of Orthopaedic Research® | Sep 1991 | 6,558 |
| 11 | Notch Signaling: Cell Fate Control and Signal Integration in Development Spyros Artavanis‐Tsakonas, Matthew D. Rand, Robert J. Lake · Science | 30 Apr 1999 | 5,977 |
| 12 | Cerebral organoids model human brain development and microcephaly Madeline A. Lancaster, Magdalena Renner, Carol-Anne Martin et al. · Nature | 27 Aug 2013 | 5,545 |
| 13 | A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells B Bernstein, Tarjei S. Mikkelsen, Xiaohui S. Xie et al. · Cell | Apr 2006 | 5,522 |
| 14 | Viable offspring derived from fetal and adult mammalian cells I. Wilmut, Angelika Schnieke, J. McWhir et al. · Nature | Feb 1997 | 4,968 |
| 15 | Mammalian Neural Stem Cells Fred H. Gage · Science | 25 Feb 2000 | 4,770 |
| 16 | Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC) Sabine Stöckl, Claudia Göttl, Joachim K. Grifka et al. · Cellular Physiology and Biochemistry | 2013 | 4,664 |
| 17 | Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells Laurie A. Boyer, Tong Ihn Lee, Megan F. Cole et al. · Cell | Sep 2005 | 4,557 |
| 18 | Generation of germline-competent induced pluripotent stem cells Keisuke Okita, Tomoko Ichisaka, Shinya Yamanaka · Nature | 6 Jun 2007 | 4,268 |
| 19 | Targeted mutation of the DNA methyltransferase gene results in embryonic lethality En Li, Timothy H. Bestor, Rudolf Jaenisch · Cell | Jun 1992 | 4,009 |
| 20 | TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival Ken Inoki, Tianqing Zhu, Kun‐Liang Guan · Cell | Nov 2003 | 3,949 |
| 21 | ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering Thomas Gaj, Charles A. Gersbach, Carlos F. Barbas · Trends in biotechnology | 8 May 2013 | 3,844 |
| 22 | Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling Stuart M. Chambers, Christopher A. Fasano, Eirini P. Papapetrou et al. · Nature Biotechnology | Mar 2009 | 3,745 |
| 23 | Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells Hitoshi Niwa, Jun‐ichi Miyazaki, Austin G Smith · Nature Genetics | Apr 2000 | 3,640 |
| 24 | The ground state of embryonic stem cell self-renewal Qi‐Long Ying, Jason P. Wray, Jennifer Nichols et al. · Nature | May 2008 | 3,583 |
| 25 | Organoid Models and Applications in Biomedical Research Christodoulos Xinaris, Valerio Brizi, Giuseppe Remuzzi · The Nephron journals/Nephron journals | 2015 | 3,519 |
| 26 | Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4 Jennifer Nichols, Branko Zevnik, Konstantinos Anastassiadis et al. · Cell | Oct 1998 | 3,421 |
| 27 | Microfluidic organs-on-chips Sangeeta N. Bhatia, Donald E. Ingber · Nature Biotechnology | Aug 2014 | 3,302 |
| 28 | Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells Ian Chambers, Douglas Colby, Morag Robertson et al. · Cell | May 2003 | 3,286 |
| 29 | Modeling Development and Disease with Organoids Hans C. Clevers · Cell | Jun 2016 | 3,282 |
| 30 | Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences. C C Mello, James M. Kramer, Dan T. Stinchcomb et al. · The EMBO Journal | Dec 1991 | 3,256 |
| 31 | The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells Kaoru Mitsui, Yoshimi Tokuzawa, Hiroaki Itoh et al. · Cell | May 2003 | 3,235 |
| 32 | Specification of Cerebral Cortical Areas PASKO T. RAKIC · Science | 8 Jul 1988 | 3,175 |
| 33 | CNS stem cells express a new class of intermediate filament protein Urban Lendahl, Lyle B. Zimmerman, Ronald D.G. McKay · Cell | Feb 1990 | 3,172 |
| 34 | The Nerve Growth Factor 35 Years Later Rita Levi‐Montalcini · Science | 4 Sep 1987 | 3,146 |
| 35 | Direct conversion of fibroblasts to functional neurons by defined factors Thomas Vierbuchen, Austin Ostermeier, Zhiping P. Pang et al. · Nature | 27 Jan 2010 | 3,068 |
| 36 | Checkpoints: Controls That Ensure the Order of Cell Cycle Events Leland H. Hartwell, Ted A. Weinert · Science | 3 Nov 1989 | 3,060 |
| 37 | Organogenesis in a dish: Modeling development and disease using organoid technologies Madeline A. Lancaster, Juergen A. Knoblich · Science | 17 Jul 2014 | 2,936 |
| 38 | Reprogramming of human somatic cells to pluripotency with defined factors In‐Hyun Park, Rui Zhao, Jason A. West et al. · Nature | 23 Dec 2007 | 2,890 |
| 39 | Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes Hartmut Land, Luis F. Parada, Robert A. Weinberg · Nature | Aug 1983 | 2,873 |
| 40 | Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts Masato Nakagawa, Michiyo Koyanagi, Koji Tanabe et al. · Nature Biotechnology | 30 Nov 2007 | 2,802 |
| 41 | QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES George J. Todaro, Howard Green · The Journal of Cell Biology | May 1963 | 2,773 |
| 42 | Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro Benjamin E. Reubinoff, Martín F. Pera, Chui‐Yee Fong et al. · Nature Biotechnology | Apr 2000 | 2,715 |
| 43 | In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state Marius Wernig, Alexander Meissner, Ruth K. Foreman et al. · Nature | 6 Jun 2007 | 2,682 |
| 44 | Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA Luigi A. Warren, Philip D. Manos, Tim Ahfeldt et al. · Cell stem cell | Oct 2010 | 2,672 |
| 45 | An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors Ittai Ben‐Porath, Matthew Thomson, Vincent J. Carey et al. · Nature Genetics | 28 Apr 2008 | 2,612 |
| 46 | Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells Xi Chen et al. · Cell | Jun 2008 | 2,589 |
| 47 | Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification Shinsuke Ito, Ana C. D’Alessio, Olena Taranova et al. · Nature | 18 Jul 2010 | 2,570 |
| 48 | Polycomb complexes repress developmental regulators in murine embryonic stem cells Laurie A. Boyer, Kathrin Plath, Julia Zeitlinger et al. · Nature | 19 Apr 2006 | 2,552 |
| 49 | Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors Masaki Ieda, Ji‐Dong Fu, Paul Delgado-Olguı́n et al. · Cell | Aug 2010 | 2,491 |
| 50 | The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells Yuin‐Han Loh et al. · Nature Genetics | 5 Mar 2006 | 2,485 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.