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Pluripotent Stem Cells Research

Pluripotent Stem Cells Research is a research topic within Molecular Biology. Science Explorer counts 39k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the induction, differentiation, and reprogramming of pluripotent stem cells, including embryonic and induced pluripotent stem cells. It covers topics such as transcriptional regulatory circuitry, neural and cardiac differentiation, epigenetic memory, and the use of defined factors for reprogramming. The research also explores the potential applications of pluripotent stem cells in modeling development, disease, and tissue regeneration.

  • Pluripotent Stem Cells
  • Induced Pluripotent Stem Cells
  • Embryonic Stem Cells
  • Differentiation
  • Reprogramming
  • Transcriptional Regulation
  • Neural Differentiation
  • Cardiomyocytes
  • Epigenetic Remodeling
  • Cellular Reprogramming
Research works
39k
fractional, since 1950
In the world top 10%
3.8k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-9%
the tick is no change
Largest producer
United States
34% of the 10 largest, 2022-now
Pluripotent Stem Cells Research

Which countries lead Pluripotent Stem Cells Research research?

By volume, the United States and China publish the most (1.7k and 1.2k works in 2022-now).

By volume, 2022-now

  1. 1 United States 1.7k works
  2. 2 China 1.2k works
  3. 3 Japan 484 works
  4. 4 Germany 313 works
  5. 5 United Kingdom 295 works
  6. 6 India 256 works
  7. 7 South Korea 227 works
  8. 8 France 176 works
  9. 9 Canada 176 works
  10. 10 Italy 167 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 33.9%China: 24.1%Japan: 9.7%Germany: 6.3%6 others listed: 26.0%34%largest
United States1,694 · 33.9%China1,206 · 24.1%Japan484 · 9.7%Germany313 · 6.3%6 others listed1,297 · 26.0%

Shares of the rows listed above, not of the whole node.

Which institutions lead Pluripotent Stem Cells Research research?

By volume in 2022-now, Harvard University publishes the most Pluripotent Stem Cells Research research, followed by Chinese Academy of Sciences and Russian Academy of Sciences.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 90 works
  2. 2 Chinese Academy of SciencesChina 75 works
  3. 3 Russian Academy of SciencesRussia 52 works
  4. 4 Kyoto UniversityJapan 52 works
  5. 5 InsermFrance 44 works
  6. 6 Centre National de la Recherche ScientifiqueFrance 42 works
  7. 7 National Institutes of HealthUnited States 40 works
  8. 8 Stanford UniversityUnited States 40 works
  9. 9 Peking UniversityChina 35 works
  10. 10 University of TorontoCanada 35 works

Who are the leading researchers in Pluripotent Stem Cells Research?

The most-cited researchers publishing on Pluripotent Stem Cells Research include Eric S. Lander, Richard M. Durbin and Guido Kroemer.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 Richard M. Durbin United Kingdom 410k citations
  3. 3 Guido Kroemer France 386k citations
  4. 4 Elaine R. Mardis United States 346k citations
  5. 5 Jun Wang China 340k citations
  6. 6 Giuseppe Remuzzi Italy 328k citations
  7. 7 John P. A. Ioannidis United States 317k citations
  8. 8 Matthias Mann Germany 308k citations
  9. 9 Róbert Langer United States 303k citations
  10. 10 Robert A. Weinberg United States 301k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Pluripotent Stem Cells Research?

The most cited paper in Pluripotent Stem Cells Research is "Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors" (Kazutoshi Takahashi, Shinya Yamanaka, 2006), with 26,957 citations. Next come "Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors" (20,424) and "Embryonic Stem Cell Lines Derived from Human Blastocysts" (16,067).

Most cited papers
#PaperReleasedCitations
1 Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors Kazutoshi Takahashi, Shinya Yamanaka · Cell Open access Aug 2006 26,957
2 Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki et al. · Cell Nov 2007 20,424
3 Embryonic Stem Cell Lines Derived from Human Blastocysts James Alexander Thomson, Joseph Itskovitz‐Eldor, Sander S. Shapiro et al. · Science 6 Nov 1998 16,067
4 Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Andrew Z. Fire, Siqun Xu, Mary Katherine Montgomery et al. · Nature Open access Feb 1998 15,508
5 Matrix Elasticity Directs Stem Cell Lineage Specification Adam Jeffrey Engler, Shamik Sen, Hugh Lee Sweeney et al. · Cell Open access Aug 2006 13,994
All 99 most cited papers, with filters and sorting

Where is Pluripotent Stem Cells Research research done?

The largest centres of Pluripotent Stem Cells Research research in 2022-now are Beijing (China), Tokyo (Japan), Shanghai (China) and Seoul (South Korea). Among places with at least 20 works in it, it is an unusually large share of all research in Kyoto and Leiden.

Largest cities, 2022-now

  1. 1 BeijingChina 215 works
  2. 2 TokyoJapan 145 works
  3. 3 ShanghaiChina 119 works
  4. 4 SeoulSouth Korea 101 works
  5. 5 GuangzhouChina 101 works
  6. 6 LondonUnited Kingdom 96 works
  7. 7 New YorkUnited States 95 works
  8. 8 ParisFrance 92 works
  9. 9 CambridgeUnited States 67 works
  10. 10 KyotoJapan 62 works

Where it is the local speciality

  1. KyotoJP · 62.4 works6.6×
  2. LeidenNL · 24.0 works5.5×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Pluripotent Stem Cells Research than the world average.

See Pluripotent Stem Cells Research on the map

Where is the best place to study Pluripotent Stem Cells Research?

Among universities, judged by research, Harvard University, Peking University and University of Cambridge score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 16.39%fractional works in this field (log) →share of work in the world top 10% →Peking UniversityHarvard UniversityUniversity of Cambri…Stanford University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 77.519.1%5.0×90 -4.2%
2Peking UniversityChina 62.820.5%3.0×35 +46.0%
3University of CambridgeUnited Kingdom 62.318.7%4.6×31 -39.1%
4Stanford UniversityUnited States 59.118.1%4.8×40 -26.4%
5Leiden UniversityNetherlands 55.113.8%7.0×22 +16.6%
6University of TorontoCanada 54.911.4%3.0×35 -0.9%
7Massachusetts Institute of TechnologyUnited States 54.220.2%3.1×12 -34.6%
8Karolinska InstitutetSweden 52.714.8%5.4×17 +12.9%
9University of PennsylvaniaUnited States 52.415.2%3.8×23 +4.2%
10Rockefeller UniversityUnited States 52.312.1%29.1×10 +10.5%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Pluripotent Stem Cells Research, country by country

Is Pluripotent Stem Cells Research research growing?

Output in 2022-2025 was 9% lower than in 2018-2021, peaking in 2014.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Pluripotent Stem Cells Research as a percentage of every work published that year, 0.024% in 2024.

still counting0.020%0.040%0.060%Pluripotent Stem Cells Research0.026% in 202519801990200020102020

Fractional works of Pluripotent Stem Cells Research over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Pluripotent Stem Cells Research10.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Questions people ask

Who leads stem cell research?

By volume in 2022-now, Harvard University publishes the most Pluripotent Stem Cells Research research, followed by Chinese Academy of Sciences and Russian Academy of Sciences. By volume, the United States and China publish the most (1.7k and 1.2k works in 2022-now).

All 1,273 questions in the Question Catalogue

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