Most cited papers in Prion Diseases and Protein Misfolding
What are the most cited papers in Prion Diseases and Protein Misfolding?
The most cited paper in Prion Diseases and Protein Misfolding is "The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics" (John Hardy, Dennis J. Selkoe, 2002), with 14,017 citations. Next come "Protein Misfolding, Functional Amyloid, and Human Disease" (6,490) and "Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016" (5,824).
Showing 50 of 100 papers. Every paper with more than 1,245 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics John Hardy, Dennis J. Selkoe · Science | 19 Jul 2002 | 14,017 |
| 2 | Protein Misfolding, Functional Amyloid, and Human Disease Fabrizio Chiti, Christopher Martin Dobson · Annual Review of Biochemistry | 7 Apr 2006 | 6,490 |
| 3 | Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 Valery L. Feigin et al. · The Lancet Neurology | 14 Mar 2019 | 5,824 |
| 4 | Prions Stanley Ben Prusiner · Proceedings of the National Academy of Sciences | 10 Nov 1998 | 5,428 |
| 5 | Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein George G. Glenner, Caine W. Wong · Biochemical and Biophysical Research Communications | May 1984 | 5,424 |
| 6 | Novel Proteinaceous Infectious Particles Cause Scrapie Stanley Ben Prusiner · Science | 9 Apr 1982 | 5,188 |
| 7 | Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide Christian Haass, Dennis J. Selkoe · Nature Reviews Molecular Cell Biology | 24 Jan 2007 | 4,786 |
| 8 | The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor Jie Kang, Hans-Georg Lemaire, Axel Unterbeck et al. · Nature | Feb 1987 | 4,640 |
| 9 | Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis Rakez Kayed, Elizabeth Head, Jennifer L. Thompson et al. · Science | 17 Apr 2003 | 4,103 |
| 10 | Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation Holly D. Oakley, Sarah L. Cole, Sreemathi Logan et al. · Journal of Neuroscience | 4 Oct 2006 | 3,665 |
| 11 | Protein aggregation and neurodegenerative disease Christopher A. Ross, Michelle A. Poirier · Nature Medicine | Jul 2004 | 3,526 |
| 12 | Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity John O’Brien, Ian D. Wilson, Terry C. Orton et al. · European Journal of Biochemistry | Sep 2000 | 3,452 |
| 13 | Central Dogma of Molecular Biology Francis Harry Compton Crick · Nature | Aug 1970 | 3,450 |
| 14 | Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade Fabrizio Chiti, Christopher Martin Dobson · Annual Review of Biochemistry | 12 May 2017 | 2,740 |
| 15 | A new variant of Creutzfeldt-Jakob disease in the UK Robert G. Will, James W. Ironside, Martin Zeidler et al. · The Lancet | Apr 1996 | 2,714 |
| 16 | TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis Jemeen Sreedharan, Ian P. Blair, Vineeta B. Tripathi et al. · Science | 28 Feb 2008 | 2,678 |
| 17 | Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein Dora Games et al. · Nature | Feb 1995 | 2,521 |
| 18 | Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases Monica Bucciantini, Elisa Giannoni, Fabrizio Chiti et al. · Nature | Apr 2002 | 2,457 |
| 19 | The new global map of human brucellosis Georgios Pappas, Photini Papadimitriou, Nikolaos Akritidis et al. · The Lancet Infectious Diseases | 27 Jan 2006 | 2,302 |
| 20 | Atomic structures of amyloid cross-β spines reveal varied steric zippers Michael R. Sawaya, Shilpa Sambashivan, Rebecca A. Nelson et al. · Nature | 29 Apr 2007 | 2,301 |
| 21 | Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. K M Pan, M. A. Baldwin, Jack T Nguyen et al. · Proceedings of the National Academy of Sciences | Dec 1993 | 2,280 |
| 22 | Molecular mechanism of Thioflavin-T binding to amyloid fibrils Matthew Biancalana, Shohei Koide · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 17 Apr 2010 | 2,253 |
| 23 | Amyloid-β and Tau George S. Bloom · JAMA Neurology | 3 Feb 2014 | 2,235 |
| 24 | Structure of the cross-β spine of amyloid-like fibrils Rebecca A. Nelson, Michael R. Sawaya, Melinda Balbirnie et al. · Nature | Jun 2005 | 2,229 |
| 25 | Cryo-EM structures of tau filaments from Alzheimer’s disease Anthony W. P. Fitzpatrick, Benjamin Falcon, Shaoda He et al. · Nature | Jul 2017 | 2,216 |
| 26 | Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie? Joseph T. Jarrett, Peter T. Lansbury · Cell | Jun 1993 | 2,194 |
| 27 | Decoding ALS: from genes to mechanism J. Paul Taylor, Robert H. Brown, Don W. Cleveland · Nature | 8 Nov 2016 | 2,158 |
| 28 | A Century of Alzheimer's Disease Michel Goedert, Maria Grazia Spillantini · Science | 2 Nov 2006 | 2,127 |
| 29 | Mice devoid of PrP are resistant to scrapie Hansruedi Büeler, Adriano Aguzzi, Andreas W. Sailer et al. · Cell | Jul 1993 | 2,107 |
| 30 | Hydrogen peroxide mediates amyloid β protein toxicity Christian Behl · Cell | 17 Jun 1994 | 2,079 |
| 31 | The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease Joseph T. Jarrett, Elizabeth P. Berger, Peter T. Lansbury · Biochemistry | 11 May 1993 | 2,029 |
| 32 | Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease Frédérique Bard et al. · Nature Medicine | Aug 2000 | 2,025 |
| 33 | Molecular Biology of Prion Diseases Stanley Ben Prusiner · Science | 14 Jun 1991 | 1,992 |
| 34 | Transmissions to mice indicate that ‘new variant’ CJD is caused by the BSE agent M. E. Bruce, Robert G. Will, James W. Ironside et al. · Nature | Oct 1997 | 1,991 |
| 35 | Protein misfolding, evolution and disease Christopher Martin Dobson · Trends in Biochemical Sciences | Sep 1999 | 1,979 |
| 36 | Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski et al. · Nature | Apr 1999 | 1,935 |
| 37 | Amyloid β-peptide is produced by cultured cells during normal metabolism Christian Haass, Michael G. Schlossmacher, Albert Y. Hung et al. · Nature | Sep 1992 | 1,917 |
| 38 | High-Level Neuronal Expression of Aβ1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation Lennart Mucke, Eliezer Masliah, Gui-Qiu Yu et al. · Journal of Neuroscience | Jun 2000 | 1,892 |
| 39 | Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis Shuo‐Chien Ling, Magdalini Polymenidou, Don W. Cleveland · Neuron | Aug 2013 | 1,887 |
| 40 | Transmission and spreading of tauopathy in transgenic mouse brain Florence Clavaguera, Tristan Bolmont, R. Anthony Crowther et al. · Nature Cell Biology | 7 Jun 2009 | 1,865 |
| 41 | Soluble pool of A? amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease Catriona McLean, Robert A. Cherny, Fiona W. Fraser et al. · Annals of Neurology | Dec 1999 | 1,823 |
| 42 | The Amyloid State of Proteins in Human Diseases David S Eisenberg, Mathias Jucker · Cell | Mar 2012 | 1,795 |
| 43 | Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. Inge Grundke‐Iqbal, Khalid Iqbal, M Quinlan et al. · Journal of Biological Chemistry | May 1986 | 1,790 |
| 44 | Alzheimer's Disease and the Amyloid-β Peptide Michael P. Murphy, Harry LeVine · Journal of Alzheimer s Disease | 6 Jan 2010 | 1,769 |
| 45 | Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production Martin Citron, Tilman Oltersdorf, Christian Haass et al. · Nature | Dec 1992 | 1,762 |
| 46 | Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis) Elena Gaggelli, Henryk Kozłowski, Daniela Valensin et al. · Chemical Reviews | Jun 2006 | 1,743 |
| 47 | Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD John Collinge, Katie C. L. Sidle, Julie Meads et al. · Nature | Oct 1996 | 1,740 |
| 48 | Self-propagation of pathogenic protein aggregates in neurodegenerative diseases Mathias Jucker, Lary C. Walker · Nature | 3 Sep 2013 | 1,704 |
| 49 | Self-Propagating, Molecular-Level Polymorphism in Alzheimer's ß-Amyloid Fibrils Aneta T. Petkova, Richard D. Leapman, Zhihong Guo et al. · Science | 13 Jan 2005 | 1,696 |
| 50 | Pathology of Neurodegenerative Diseases Brittany N. Dugger, Dennis W. Dickson · Cold Spring Harbor Perspectives in Biology | 6 Jan 2017 | 1,673 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.