Prion Diseases and Protein Misfolding
Prion Diseases and Protein Misfolding is a research topic within Molecular Biology. Science Explorer counts 17k research works in it since 1950. 18.3% of them reached the world's top 10% most cited for their field and year.
This cluster of papers focuses on the causes, molecular basis, detection, transmission, and potential treatments for prion diseases, including variant Creutzfeldt-Jakob disease. It explores the role of infectious prions, protein misfolding, and their impact on neurodegenerative diseases. The research also delves into the pathology of these diseases and their transmissibility through blood transfusion.
- Prion Diseases
- Molecular Basis
- Pathological Protein Misfolding
- Variant Creutzfeldt-Jakob Disease
- Infectious Prions
- Neurodegenerative Diseases
- Protein Aggregation
- Transmissible Spongiform Encephalopathies
- Cyclic Amplification
- Cellular Prion Protein
- Research works
- 17k fractional, since 1950
- In the world top 10%
- 3.1k per year above
- Top-10% rate
- 18.3% share of its works in the world top 10%
- Growth, 2013–17 → 2018–22
- -9% the tick is no change
Which countries lead Prion Diseases and Protein Misfolding research?
By volume, the United States and China publish the most (457 and 138 works in 2022–2025).
By volume, 2022–2025
- 1 United States 457 works
- 2 China 138 works
- 3 United Kingdom 110 works
- 4 Japan 89 works
- 5 Italy 83 works
- 6 India 76 works
- 7 France 68 works
- 8 Germany 68 works
- 9 Canada 66 works
- 10 Spain 54 works
How concentrated that is
The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.
Shares of the rows listed above, not of the whole node.
Which institutions lead Prion Diseases and Protein Misfolding research?
By volume in 2022–2025, Colorado State University publishes the most Prion Diseases and Protein Misfolding research, followed by University of Edinburgh and Capital Medical University.
By volume, 2022–2025
- 1 Colorado State UniversityUnited States 15 works
- 2 University of EdinburghUnited Kingdom 12 works
- 3 Capital Medical UniversityChina 12 works
- 4 University College LondonUnited Kingdom 11 works
- 5 National Institutes of HealthUnited States 10 works
- 6 University of AlbertaCanada 10 works
- 7 Case Western Reserve UniversityUnited States 10 works
- 8 National Institute of Allergy and Infectious DiseasesUnited States 9 works
- 9 Jeonbuk National UniversitySouth Korea 8 works
- 10 Creighton UniversityUnited States 7 works
Who are the leading researchers in Prion Diseases and Protein Misfolding?
The most-cited researchers publishing on Prion Diseases and Protein Misfolding include John Hardy, Kaj Blennow and Henrik Zetterberg.
- 1 John Hardy United Kingdom 4k citations
- 2 Kaj Blennow Sweden 3.4k citations
- 3 Henrik Zetterberg Sweden 3.1k citations
- 4 Bruce L. Miller United States 3k citations
- 5 David M. Holtzman United States 2.8k citations
- 6 Dennis W. Dickson United States 2.8k citations
- 7 John Q. Trojanowski United States 2.6k citations
Ranked by citations received across their whole record, among researchers with at least three works on this topic.
Where is Prion Diseases and Protein Misfolding research done?
The largest centres of Prion Diseases and Protein Misfolding research in 2022–2025 are London (United Kingdom), Beijing (China), Paris (France) and Bethesda (United States). Among places with at least 20 works in it, it is an unusually large share of all research in Bethesda.
Largest cities, 2022–2025
Where it is the local speciality
- BethesdaUS · 24.4 works13×
Location quotient: how much more of its research is in Prion Diseases and Protein Misfolding than the world average.
Where is the best place to study Prion Diseases and Protein Misfolding?
Among universities, judged by research, Colorado State University, University College London and Case Western Reserve University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.
One dot per university in the table below. The upper left is the interesting corner: small places doing unusually strong work.
| # | University | Score | Top 10% | Specialisation | Works | Growth |
|---|---|---|---|---|---|---|
| 1 | Colorado State UniversityUnited States | 82.3 | 19.1% | 26.4× | 15 | +44.5% |
| 2 | University College LondonUnited Kingdom | 50.6 | 27.4% | 4.9× | 10 | -2.6% |
| 3 | Case Western Reserve UniversityUnited States | 49.2 | 16.7% | 17.5× | 10 | -12.4% |
| 4 | University of EdinburghUnited Kingdom | 48.2 | 4.6% | 10.1× | 12 | -16.8% |
| 5 | University of AlbertaCanada | 42.3 | 15.0% | 7.7× | 10 | -20.3% |
| 6 | Capital Medical UniversityChina | 41.1 | 1.6% | 12.9× | 12 | — |
Universities only. Score blends excellence (30%), specialisation (25%), size (20%), growth (15%) and international reach (10%), 2015–2022; growth compares 2010–14 with 2015–19.
Is Prion Diseases and Protein Misfolding research growing?
Output in 2018–2022 was 9% lower than in 2013–2017, peaking in 2006.
The same series as a ribbon — one cell per year, darker for more. The line above answers how much; this answers when.
Which topics inside it are moving
Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.