Most cited papers in Protease and Inhibitor Mechanisms
What are the most cited papers in Protease and Inhibitor Mechanisms?
The most cited paper in Protease and Inhibitor Mechanisms is "Tissue Plasminogen Activator for Acute Ischemic Stroke" (The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study G, 1995), with 11,752 citations. Next come "The pathogenesis of atherosclerosis: a perspective for the 1990s" (10,703) and "New functions for the matrix metalloproteinases in cancer progression" (6,127).
Showing 50 of 100 papers. Every paper with more than 1,312 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Tissue Plasminogen Activator for Acute Ischemic Stroke The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study G · New England Journal of Medicine | 14 Dec 1995 | 11,752 |
| 2 | The pathogenesis of atherosclerosis: a perspective for the 1990s Russell Ross · Nature | Apr 1993 | 10,703 |
| 3 | New functions for the matrix metalloproteinases in cancer progression Mikala Egeblad, Zena Werb · Nature reviews. Cancer | Mar 2002 | 6,127 |
| 4 | Matrix Metalloproteinases: Regulators of the Tumor Microenvironment Kai Kessenbrock, Vicki Plaks, Zena Werb · Cell | Apr 2010 | 5,146 |
| 5 | Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases Robert Visse, Hideaki Nagase · Circulation Research | May 2003 | 4,573 |
| 6 | Remodelling the extracellular matrix in development and disease Caroline Bonnans, Jonathan Chou, Zena Werb · Nature Reviews Molecular Cell Biology | 21 Nov 2014 | 4,490 |
| 7 | How Matrix Metalloproteinases Regulate Cell Behavior Mark D. Sternlicht, Zena Werb · Annual Review of Cell and Developmental Biology | Nov 2001 | 3,957 |
| 8 | Matrix Metalloproteinases Hideaki Nagase, J. Frederick Woessner · Journal of Biological Chemistry | Jul 1999 | 3,917 |
| 9 | Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome Gregory G. Schwartz et al. · New England Journal of Medicine | 7 Nov 2018 | 3,654 |
| 10 | An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation Salvador Moncada, Ryszard Jerzy Gryglewski, S Bunting et al. · Nature | Oct 1976 | 3,608 |
| 11 | Structure and function of matrix metalloproteinases and TIMPs Hiroyuki Nagase, Robert Visse, G MURPHY · Cardiovascular Research | 6 Jan 2006 | 3,436 |
| 12 | Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma M. OʼReilly · Cell | 21 Oct 1994 | 3,369 |
| 13 | Matrix metalloproteinases and their inhibitors in connective tissue remodeling J. Frederick Woessner · The FASEB Journal | May 1991 | 3,305 |
| 14 | Tumour-cell invasion and migration: diversity and escape mechanisms Peter Friedl, Katarina Wolf · Nature reviews. Cancer | May 2003 | 3,265 |
| 15 | Sequence Variations in PCSK9, Low LDL, and Protection against Coronary Heart Disease Jonathan C. Cohen, Eric Boerwinkle, Thomas H. Mosley et al. · New England Journal of Medicine | 22 Mar 2006 | 3,254 |
| 16 | A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells Roy A. Black, Charles T. Rauch, Carl J. Kozlosky et al. · Nature | Feb 1997 | 3,168 |
| 17 | Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Harold F. Dvorak, Lawrence F. Brown, Michael J. Detmar et al. · PubMed | May 1995 | 3,129 |
| 18 | Intra-arterial Prourokinase for Acute Ischemic Stroke Anthony J. Furlan, Randall T. Higashida, Lawrence R. Wechsler et al. · JAMA | Dec 1999 | 3,083 |
| 19 | Matrix metalloproteinases and the regulation of tissue remodelling Andrea Page-McCaw, Andrew J. Ewald, Zena Werb · Nature Reviews Molecular Cell Biology | 23 Feb 2007 | 3,033 |
| 20 | Matrix Metalloproteinases: A Review Henning Birkedal‐Hansen, William G. I. Moore, Malena Bodden et al. · Critical Reviews in Oral Biology & Medicine | 1993 | 2,995 |
| 21 | Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis Gabriele Bergers, Rolf A. Brekken, Gerald McMahon et al. · Nature Cell Biology | 20 Sep 2000 | 2,809 |
| 22 | Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations Lisa M. Coussens, Barbara Fingleton, Lynn McCormick Matrisian · Science | 29 Mar 2002 | 2,775 |
| 23 | Angiogenesis. Judah Folkman, Yuen Shing · Journal of Biological Chemistry | Jun 1992 | 2,673 |
| 24 | Collagens—structure, function, and biosynthesis Kolja Gelse · Advanced Drug Delivery Reviews | 29 Oct 2003 | 2,643 |
| 25 | A matrix metalloproteinase expressed on the surface of invasive tumour cells Hiroshi Sato, Takahisa Takino, Yasunori Okada et al. · Nature | Jul 1994 | 2,576 |
| 26 | Silk as a biomaterial Charu Vepari, David Lee Kaplan · Progress in Polymer Science | 12 Jun 2007 | 2,573 |
| 27 | Plasminogen Activators, Tissue Degradation, and Cancer Keld Danø, P.A. Andreasen, Jan Grøndahl-Hansen et al. · Advances in cancer research | 1985 | 2,563 |
| 28 | Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. Zorina S. Galis, Galina K. Sukhova, Michael W. Lark et al. · Journal of Clinical Investigation | Dec 1994 | 2,547 |
| 29 | Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. Ronald A. Ignotz, Joan Massagué · Journal of Biological Chemistry | Mar 1986 | 2,512 |
| 30 | Thrombin signalling and protease-activated receptors Shaun R. Coughlin · Nature | Sep 2000 | 2,497 |
| 31 | The microenvironment of the tumour–host interface Lance A. Liotta, Elise C. Kohn · Nature | May 2001 | 2,338 |
| 32 | Pathology of the Vulnerable Plaque Renu Virmani, ALLEN P. BURKE, Andrew A. Farb et al. · Journal of the American College of Cardiology | Apr 2006 | 2,326 |
| 33 | Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels Peter C. Brooks, Anthony M.P. Montgomery, Mauricio Rosenfeld et al. · Cell | Dec 1994 | 2,281 |
| 34 | American Society of Clinical Oncology 2007 Update of Recommendations for the Use of Tumor Markers in Breast Cancer Lyndsay N. Harris, Herbert A. Fritsche, Robert Gary Mennel et al. · Journal of Clinical Oncology | 22 Oct 2007 | 2,233 |
| 35 | Vascular Smooth Muscle Cells in Atherosclerosis Martin R. Bennett, Sanjay Kumar Sinha, Gary K. Owens · Circulation Research | 18 Feb 2016 | 2,203 |
| 36 | Plasminogen: Purification from Human Plasma by Affinity Chromatography Dale G. Deutsch, Edwin T. Mertz · Science | 4 Dec 1970 | 2,146 |
| 37 | Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene Harry C. Dietz, Carry R. Cutting, Reed Edwin Pyeritz et al. · Nature | Jul 1991 | 2,089 |
| 38 | Endothelial/Pericyte Interactions Annika Armulik, Alexandra Abramsson, Christer Betsholtz · Circulation Research | 15 Sep 2005 | 2,064 |
| 39 | Annexins: From Structure to Function Volker Gerke, Stephen E. Moss · Physiological Reviews | Apr 2002 | 2,056 |
| 40 | Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer Shanu Modi et al. · New England Journal of Medicine | 11 Dec 2019 | 2,026 |
| 41 | Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates Christa Heussen, Eugene B. Dowdle · Analytical Biochemistry | Feb 1980 | 1,987 |
| 42 | Matrix metalloproteinases and tumor metastasis Elena I. Deryugina, James P. Quigley · Cancer and Metastasis Reviews | Mar 2006 | 1,973 |
| 43 | Binding of soluble form of fibroblast surface protein, fibronectin, to collagen Eva Olsson Engvall, Erkki I. Ruoslahti · International Journal of Cancer | 15 Jul 1977 | 1,962 |
| 44 | Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Qin Yu, Ivan Stamenkovic · PubMed | 15 Jan 2000 | 1,957 |
| 45 | Matrix metalloproteinases as modulators of inflammation and innate immunity William C. Parks, Carole L. Wilson, Yolanda S. López-Boado · Nature reviews. Immunology | 30 Jul 2004 | 1,934 |
| 46 | Heparin-Protein Interactions Ishan Capila, Robert J. Linhardt · Angewandte Chemie International Edition | 29 Jan 2002 | 1,925 |
| 47 | Tissue inhibitors of metalloproteinases: evolution, structure and function Keith Brew, Deendayal Dinakarpandian, Hideaki Nagase · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology | Mar 2000 | 1,910 |
| 48 | cDNA sequence of human apolipoprotein(a) is homologous to plasminogen John W. McLean, James E. Tomlinson, Wun-Jing Kuang et al. · Nature | Nov 1987 | 1,898 |
| 49 | Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice Duško llić, Yasuhide Furuta, S. Kanazawa et al. · Nature | Oct 1995 | 1,853 |
| 50 | Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke Joseph P. Broderick et al. · New England Journal of Medicine | 7 Feb 2013 | 1,819 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.