Topic · Protein Tyrosine Phosphatases
Most cited papers in Protein Tyrosine Phosphatases
What are the most cited papers in Protein Tyrosine Phosphatases?
The most cited paper in Protein Tyrosine Phosphatases is "Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor" (Anne Sophie Brunet, Azad Bonni, Michael J. Zigmond et al., 1999), with 6,632 citations. Next come "A modified uronic acid carbazole reaction" (6,285) and "Rho GTPases and the Actin Cytoskeleton" (6,198).
Showing 50 of 99 papers. Every paper with more than 838 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor Anne Sophie Brunet, Azad Bonni, Michael J. Zigmond et al. · Cell | Mar 1999 | 6,632 |
| 2 | A modified uronic acid carbazole reaction Thomas Bitter, H. M. Muir · Analytical Biochemistry | Oct 1962 | 6,285 |
| 3 | Rho GTPases and the Actin Cytoskeleton Alan K. Hall · Science | 23 Jan 1998 | 6,198 |
| 4 | PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer Jing Li, Clifford Yen, Danny Liaw et al. · Science | 28 Mar 1997 | 4,843 |
| 5 | STATs and Gene Regulation James E. Darnell Jr. · Science | 12 Sep 1997 | 4,030 |
| 6 | Cell Signaling by Receptor Tyrosine Kinases Joseph Schlessinger · Cell | Oct 2000 | 3,783 |
| 7 | Principles of interleukin (IL)-6-type cytokine signalling and its regulation Peter Claus Heinrich, Iris Behrmann, Serge Haan et al. · Biochemical Journal | 15 Aug 2003 | 3,293 |
| 8 | The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate Tomohiko Maehama, Jack E. Dixon · Journal of Biological Chemistry | May 1998 | 3,124 |
| 9 | Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers Peter A. Steck, Mark A. Pershouse, Samar A. Jasser et al. · Nature Genetics | Apr 1997 | 2,772 |
| 10 | A synthetic inhibitor of the mitogen-activated protein kinase cascade. David T. Dudley, Long Pang, Stuart J. Decker et al. · Proceedings of the National Academy of Sciences | 15 Aug 1995 | 2,717 |
| 11 | Transcriptional regulation by the phosphorylation-dependent factor CREB Bernhard M. Mayr, Marc Montminy · Nature Reviews Molecular Cell Biology | Aug 2001 | 2,608 |
| 12 | Signaling—2000 and Beyond Tony R. Hunter · Cell | 2000 | 2,597 |
| 13 | Endocrine Regulation of Energy Metabolism by the Skeleton Na Kyung Lee, Hideaki Sowa, Eiichi Hinoi et al. · Cell | Aug 2007 | 2,566 |
| 14 | Mitogen-activated protein kinase pathways Megan J. Robinson, Melanie H. Cobb · Current Opinion in Cell Biology | Apr 1997 | 2,501 |
| 15 | Signaling Through Scaffold, Anchoring, and Adaptor Proteins Tony J. Pawson, John D. Scott · Science | 19 Dec 1997 | 2,292 |
| 16 | Increased Insulin Sensitivity and Obesity Resistance in Mice Lacking the Protein Tyrosine Phosphatase-1B Gene Mounib Elchebly, Paul Payette, Eva Michaliszyn et al. · Science | 5 Mar 1999 | 2,220 |
| 17 | Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway Peter Claus Heinrich, Iris Behrmann, Gerhard Müller‐Newen et al. · Biochemical Journal | Sep 1998 | 2,155 |
| 18 | Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6 Zhong Zhong, Zilong Wen, James E. Darnell Jr. · Science | Apr 1994 | 2,102 |
| 19 | Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation Zilong Wen, Zhong Zhong, James E. Darnell Jr. · Cell | Jul 1995 | 2,006 |
| 20 | Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice Christine Bôle‐Feysot, Vincent Goffin, Marc Edery et al. · Endocrine Reviews | Jun 1998 | 1,957 |
| 21 | The functions and regulation of the PTEN tumour suppressor Min Sup Song, Leonardo Salmena, Pier Paolo Pandolfi · Nature Reviews Molecular Cell Biology | 4 Apr 2012 | 1,953 |
| 22 | SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins Christine Anne Koch, Deborah H. Anderson, Michael F. Moran et al. · Science | 3 May 1991 | 1,916 |
| 23 | Protein Tyrosine Phosphatases in the Human Genome Andrés Alonso, Joanna M. Sasin, Nunzio Bottini et al. · Cell | Jun 2004 | 1,893 |
| 24 | Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain Li Deng, Chen Wang, Erika Spencer et al. · Cell | Oct 2000 | 1,893 |
| 25 | Signal Transduction through MAP Kinase Cascades Timothy S. Lewis, Paul S. Shapiro, Natalie G. Ahn · Advances in cancer research | 1998 | 1,774 |
| 26 | Ehlers-Danlos syndromes: Revised nosology, Villefranche, 1997 Peter Beighton, Anne De Paepe, Beat Steinmann et al. · American Journal of Medical Genetics | 28 Apr 1998 | 1,753 |
| 27 | Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome Marco Tartaglia, Ernest Louis Mehler, Rosalie B. Goldberg et al. · Nature Genetics | 12 Nov 2001 | 1,751 |
| 28 | STATs in oncogenesis Tammy L. Bowman, Roy Garcia, James Turkson et al. · Oncogene | 25 May 2000 | 1,741 |
| 29 | Protein tyrosine phosphatases: from genes, to function, to disease Nicholas K. Tonks · Nature Reviews Molecular Cell Biology | 23 Oct 2006 | 1,715 |
| 30 | Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling Veerle Janssens, Jozef GORIS · Biochemical Journal | Feb 2001 | 1,683 |
| 31 | PD-1/PD-L1 pathway: current researches in cancer. Yanyan Han, Dandan Liu, Lianhong Li · PubMed | 2020 | 1,641 |
| 32 | Hyperactive Ras in developmental disorders and cancer Suzanne Schubbert, KEVIN M. SHANNON, Gideon E. Bollag · Nature reviews. Cancer | 23 Mar 2007 | 1,600 |
| 33 | The JAK-STAT Pathway at Twenty George R. Stark, James E. Darnell Jr. · Immunity | Apr 2012 | 1,548 |
| 34 | Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2 Jenő Gyuris · Cell | 19 Nov 1993 | 1,539 |
| 35 | Mechanisms and regulation of endothelial VEGF receptor signalling Michael Simons, Emma J. Gordon, Lena Claesson‐Welsh · Nature Reviews Molecular Cell Biology | 27 Jul 2016 | 1,521 |
| 36 | A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis Ann B. Begovich et al. · The American Journal of Human Genetics | 29 Jun 2004 | 1,515 |
| 37 | Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF Sonja J. Heidorn, Carla S. Milagre, Steven R. Whittaker et al. · Cell | 2010 | 1,487 |
| 38 | Mechanisms of specificity in protein phosphorylation Jeffrey A. Ubersax, James E. Ferrell · Nature Reviews Molecular Cell Biology | 22 Jun 2007 | 1,480 |
| 39 | Differential regulation and properties of MAPKs Malavika Raman, Weina Chen, Melanie H. Cobb · Oncogene | 14 May 2007 | 1,432 |
| 40 | Isolated noncompaction of left ventricular myocardium. A study of eight cases. Thomas K. Chin, Joseph K. Perloff, Roberta G. Williams et al. · Circulation | Aug 1990 | 1,428 |
| 41 | A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes Nunzio Bottini, Lucia Musumeci, Andrés Alonso et al. · Nature Genetics | 7 Mar 2004 | 1,426 |
| 42 | A new protein containing an SH2 domain that inhibits JAK kinases Takaho A. Endo, Masaaki Masuhara, Masahiro Yokouchi et al. · Nature | 26 Jun 1997 | 1,420 |
| 43 | The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review) Fatima Ardito, Michele Giuliani, DONATELLA PERRONE et al. · International Journal of Molecular Medicine | 22 Jun 2017 | 1,405 |
| 44 | Genome-wide association study of blood pressure and hypertension Daniel Levy et al. · Nature Genetics | 10 May 2009 | 1,397 |
| 45 | Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes Alvin Ziying Lu, Venkat Giri Magupalli, Jianbin Ruan et al. · Cell | Mar 2014 | 1,377 |
| 46 | The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions Seunghee Yoon, Rony Seger · Growth Factors | 2006 | 1,290 |
| 47 | JAK-STAT Signaling: From Interferons to Cytokines Christian Schindler, David E. Levy, Thomas Decker · Journal of Biological Chemistry | 14 May 2007 | 1,279 |
| 48 | Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale · Cell | Apr 2008 | 1,276 |
| 49 | ERK signalling: a master regulator of cell behaviour, life and fate Hugo Lavoie, Jessica K. Gagnon, Marc Therrien · Nature Reviews Molecular Cell Biology | 23 Jun 2020 | 1,258 |
| 50 | Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice Lori D. Klaman, Olivier Boss, Odile D. Peroni et al. · Molecular and Cellular Biology | Aug 2000 | 1,243 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.