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Topic · Molecular Biology

Protein Tyrosine Phosphatases

Protein Tyrosine Phosphatases is a research topic within Molecular Biology. Science Explorer counts 13k research works in it since 1950. 10.3% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the role of protein tyrosine phosphatases, particularly PTPN11 and SHP2, in various human health and disease conditions such as Noonan syndrome, cancer, insulin sensitivity, and MAP kinase signaling. It also delves into the redox regulation of protein tyrosine phosphatases and their implications in cell signaling pathways.

  • Protein Tyrosine Phosphatases
  • PTPN11
  • Noonan Syndrome
  • MAP Kinase Signaling
  • Insulin Sensitivity
  • Cancer
  • Redox Regulation
  • SHP2
  • Mutation
  • Cell Signaling
Research works
13k
fractional, since 1950
In the world top 10%
1.3k
per year above
Top-10% rate
10.3%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+8%
the tick is no change
Largest producer
China
38% of the 10 largest, 2022-now
Protein Tyrosine Phosphatases

Which countries lead Protein Tyrosine Phosphatases research?

By volume, China and the United States publish the most (665 and 544 works in 2022-now).

By volume, 2022-now

  1. 1 China 665 works
  2. 2 United States 544 works
  3. 3 Japan 90 works
  4. 4 India 88 works
  5. 5 Italy 82 works
  6. 6 Germany 66 works
  7. 7 United Kingdom 63 works
  8. 8 France 57 works
  9. 9 South Korea 55 works
  10. 10 Spain 47 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 37.9%United States: 31.0%Japan: 5.1%India: 5.0%6 others listed: 21.0%38%largest
China665 · 37.9%United States544 · 31.0%Japan90 · 5.1%India88 · 5.0%6 others listed370 · 21.0%

Shares of the rows listed above, not of the whole node.

Which institutions lead Protein Tyrosine Phosphatases research?

By volume in 2022-now, Shanghai Jiao Tong University publishes the most Protein Tyrosine Phosphatases research, followed by Harvard University and National Institutes of Health.

By volume, 2022-now

  1. 1 Shanghai Jiao Tong UniversityChina 20 works
  2. 2 Harvard UniversityUnited States 20 works
  3. 3 National Institutes of HealthUnited States 17 works
  4. 4 Chinese Academy of SciencesChina 16 works
  5. 5 Sun Yat-sen UniversityChina 15 works
  6. 6 Zhejiang UniversityChina 15 works
  7. 7 Nanjing Medical UniversityChina 14 works
  8. 8 Centre National de la Recherche ScientifiqueFrance 12 works
  9. 9 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 12 works
  10. 10 Stanford UniversityUnited States 11 works

Who are the leading researchers in Protein Tyrosine Phosphatases?

The most-cited researchers publishing on Protein Tyrosine Phosphatases include Mark J. Daly, Peer Bork and Bert Vogelstein.

  1. 1 Mark J. Daly United States 403k citations
  2. 2 Peer Bork Germany 396k citations
  3. 3 Bert Vogelstein United States 373k citations
  4. 4 Elaine R. Mardis United States 346k citations
  5. 5 Shizuo Akira Japan 342k citations
  6. 6 Jun Wang China 340k citations
  7. 7 Matthias Mann Germany 308k citations
  8. 8 Gonçalo R. Abecasis United States 300k citations
  9. 9 Richard A. Gibbs United States 292k citations
  10. 10 Todd R. Golub United States 283k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Protein Tyrosine Phosphatases?

The most cited paper in Protein Tyrosine Phosphatases is "Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor" (Anne Sophie Brunet, Azad Bonni, Michael J. Zigmond et al., 1999), with 6,632 citations. Next come "A modified uronic acid carbazole reaction" (6,285) and "Rho GTPases and the Actin Cytoskeleton" (6,198).

Most cited papers
#PaperReleasedCitations
1 Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor Anne Sophie Brunet, Azad Bonni, Michael J. Zigmond et al. · Cell Open access Mar 1999 6,632
2 A modified uronic acid carbazole reaction Thomas Bitter, H. M. Muir · Analytical Biochemistry Oct 1962 6,285
3 Rho GTPases and the Actin Cytoskeleton Alan K. Hall · Science 23 Jan 1998 6,198
4 PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer Jing Li, Clifford Yen, Danny Liaw et al. · Science 28 Mar 1997 4,843
5 STATs and Gene Regulation James E. Darnell Jr. · Science 12 Sep 1997 4,030
All 99 most cited papers, with filters and sorting

Where is Protein Tyrosine Phosphatases research done?

The largest centres of Protein Tyrosine Phosphatases research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Nanjing (China).

Largest cities, 2022-now

  1. 1 BeijingChina 66 works
  2. 2 ShanghaiChina 61 works
  3. 3 GuangzhouChina 37 works
  4. 4 NanjingChina 34 works
  5. 5 New YorkUnited States 32 works
  6. 6 HangzhouChina 30 works
  7. 7 SeoulSouth Korea 25 works
  8. 8 ParisFrance 24 works
  9. 9 TokyoJapan 24 works
  10. 10 WuhanChina 24 works
See Protein Tyrosine Phosphatases on the map

Where is the best place to study Protein Tyrosine Phosphatases?

Among universities, judged by research, Harvard University, China Pharmaceutical University and Sun Yat-sen University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 14.43%fractional works in this field (log) →share of work in the world top 10% →China Pharmaceutical…Harvard UniversitySouthern Medical Uni…Sun Yat-sen University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 88.422.1%3.3×20 +6.2%
2China Pharmaceutical UniversityChina 58.323.7%20.0×9 +308.6%
3Sun Yat-sen UniversityChina 48.713.5%3.8×15 -8.7%
4Southern Medical UniversityChina 48.321.1%7.3×9 +58.6%
5Shanghai Jiao Tong UniversityChina 48.15.7%3.7×20 -7.3%
6Nanjing Medical UniversityChina 47.89.2%8.3×14 +50.3%
7University of CincinnatiUnited States 46.516.9%7.6×9 +63.5%
8Zhejiang UniversityChina 45.114.6%2.8×15 -14.1%
9Stanford UniversityUnited States 44.88.3%3.8×11 +148.9%
10Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 37.69.2%5.7×12 +12.4%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Protein Tyrosine Phosphatases, country by country

Is Protein Tyrosine Phosphatases research growing?

Output in 2022-2025 was 8% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Protein Tyrosine Phosphatases.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Protein Tyrosine Phosphatases as a percentage of every work published that year, 0.0086% in 2024.

still counting0.010%0.020%0.030%Protein Tyrosine Phosphatases0.0091% in 202519801990200020102020

Fractional works of Protein Tyrosine Phosphatases over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Protein Tyrosine Phosphatases10.4% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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