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Topic · Quinazolinone synthesis and applications

Most cited papers in Quinazolinone synthesis and applications

Quinazolinone synthesis and applications

What are the most cited papers in Quinazolinone synthesis and applications?

The most cited paper in Quinazolinone synthesis and applications is "Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase" (Margaret F. Favata, Kurumi Y. Horiuchi, Elizabeth J. Manos et al., 1998), with 3,045 citations. Next come "Epidermal growth factor-related peptides and their receptors in human malignancies" (2,699) and "TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function" (2,631).

Showing 50 of 99 papers. Every paper with more than 369 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase Margaret F. Favata, Kurumi Y. Horiuchi, Elizabeth J. Manos et al. · Journal of Biological Chemistry Open access Jul 1998 3,045
2 Epidermal growth factor-related peptides and their receptors in human malignancies David S. Salomon, Ralf Brandt, Fortunato Ciardiello et al. · Critical Reviews in Oncology/Hematology Jul 1995 2,699
3 TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function Anjana Rao, Chun Huai Luo, Patrick G. Hogan · Annual Review of Immunology Review Apr 1997 2,631
4 Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor Jeffrey H. Hanke, Joseph P. Gardner, Robert L. Dow et al. · Journal of Biological Chemistry Open access 1996 1,962
5 A small molecule–kinase interaction map for clinical kinase inhibitors Miles A. Fabian et al. · Nature Biotechnology Open access 13 Feb 2005 1,927
6 The activation of Akt/PKB signaling pathway and cell survival Gang Song, Gaoliang Ouyang, Shideng Bao · Journal of Cellular and Molecular Medicine Open access 2005 1,893
7 Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase Thomas Hellmut Schindler, William G. Bornmann, Patricia Pellicena et al. · Science 15 Sep 2000 1,799
8 Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation Neil A. Clipstone, Gerald R. Crabtree · Nature Jun 1992 1,648
9 BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models Dan Li, Lauren Ambrogio, Takeshi Shimamura et al. · Oncogene Open access 14 Apr 2008 1,449
10 Characterization of the Cellular Reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): Subcellular Localization, Substrate Dependence, and Involvement of Mitochondrial Electron Transport in MTT Reduction Michael V. Berridge, An S. Tan · Archives of Biochemistry and Biophysics Jun 1993 1,443
11 The specificities of protein kinase inhibitors: an update Jenny Bain, Hilary McLauchlan, Matthew Elliott et al. · Biochemical Journal Open access 26 Mar 2003 1,369
12 Discovery of N -(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays Louis J. Lombardo et al. · Journal of Medicinal Chemistry Open access Dec 2004 1,308
13 PI3K-Akt pathway: Its functions and alterations in human cancer Mitsuhiko Osaki, M Oshimura, Hisao Ito · APOPTOSIS 25 Oct 2004 1,266
14 FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics. Toru Kino, Hiroshi Hatanaka, MICHISANE HASHIMOTO et al. · The Journal of Antibiotics Open access 1987 1,255
15 Akt signalling in health and disease Ingeborg Hers, Emma E. Vincent, Jeremy M. Tavaré · Cellular Signalling 22 May 2011 1,255
16 Novel mutant-selective EGFR kinase inhibitors against EGFR T790M Wenjun Zhou, Dalia Ercan, Liang Chen et al. · Nature Open access Dec 2009 1,006
17 The MAPK pathway across different malignancies: A new perspective Mauricio Burotto, Victoria L. Chiou, Jung‐Min Lee et al. · Cancer Open access 19 Jun 2014 1,002
18 Preparation of 5-Substituted 1 H -Tetrazoles from Nitriles in Water Zachary Demko, K. Barry Sharpless · The Journal of Organic Chemistry Nov 2001 972
19 MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo Hiroshi Hirai, Hiroshi Sootome, Yoko Nakatsuru et al. · Molecular Cancer Therapeutics 22 Jun 2010 946
20 Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK) J. Jean Cui et al. · Journal of Medicinal Chemistry Open access 3 Aug 2011 936
21 Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase Bhushan Nagar, Oliver D. Hantschel, Matthew A. Young et al. · Cell Open access Mar 2003 893
22 Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker Flavio Solca, G. Dahl, Andreas Zoephel et al. · Journal of Pharmacology and Experimental Therapeutics 12 Aug 2012 881
23 5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods R. Jason Herr · Bioorganic & Medicinal Chemistry Nov 2002 856
24 Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus Matt D. Johansen, Jean‐Louis Herrmann, Laurent Kremer · Nature Reviews Microbiology Review 21 Feb 2020 846
25 Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases Ralph Hoessel, Sophie Leclerc, Jane Endicott et al. · Nature Cell Biology May 1999 823
26 Modelling Myc inhibition as a cancer therapy Laura Soucek, Jonathan Richard Whitfield, Carla P. Martins et al. · Nature Open access 17 Aug 2008 822
27 GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins Laurent Meijer, Alexios-Leandros Skaltsounis, Prokopios Magiatis et al. · Chemistry & Biology Open access Dec 2003 819
28 Trends in kinase drug discovery: targets, indications and inhibitor design Misty M. Attwood, Doriano Fabbro, Aleksandr V. Sokolov et al. · Nature Reviews Drug Discovery Review 5 Aug 2021 818
29 Mechanisms of action of cyclosporine Satoshi Matsuda, Shigeo Koyasu · Immunopharmacology May 2000 814
30 Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations Jaclyn LoPiccolo, Gideon Michael Blumenthal, Wendy B. Bernstein et al. · Drug Resistance Updates Open access 2 Jan 2008 810
31 Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents Karnail S. Atwal, Brian N. Swanson, Steven E. Unger et al. · Journal of Medicinal Chemistry Feb 1991 790
32 The chemistry of recently isolated naturally occurring quinazolinone alkaloids Santosh B. Mhaske, Narshinha P. Argade · Tetrahedron 25 Aug 2006 750
33 Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease Sophie Leclerc, Matthieu Garnier, Ralph Hoessel et al. · Journal of Biological Chemistry Open access 2001 728
34 JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis Linda S. Steelman, Steven C. Pohnert, J G Shelton et al. · Leukemia 22 Jan 2004 692
35 The mRNA 5′ cap-binding protein eIF4E and control of cell growth Nahum Sonenberg, Anne‐Claude Gingras · Current Opinion in Cell Biology Review Apr 1998 680
36 Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck André Veillette, Michael A. Bookman, Eva M Horak et al. · Nature Mar 1989 665
37 Differential Cytokine Modulation and T Cell Activation by Two Distinct Classes of Thalidomide Analogues That Are Potent Inhibitors of TNF-α Laura G. Corral, Patrick A. J. Haslett, George W. Muller et al. · The Journal of Immunology Jul 1999 658
38 The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones Timothy Mark Willson, Jeffery E. Cobb, David J. Cowan et al. · Journal of Medicinal Chemistry Open access 1996 640
39 Synthesis of quinazolinones and quinazolines David J. Connolly, Declan Cusack, Timothy P. O’Sullivan et al. · Tetrahedron 10 Aug 2005 627
40 Mechanisms of Autoinhibition and STI-571/Imatinib Resistance Revealed by Mutagenesis of BCR-ABL MOHAMMAD U AZAM, Robert Raymond Latek, George Q. Daley · Cell Open access Mar 2003 626
41 The target of rapamycin (TOR) proteins Brian Raught, Anne‐Claude Gingras, Nahum Sonenberg · Proceedings of the National Academy of Sciences Open access 19 Jun 2001 620
42 Catalyzed Addition of Aldehydes to Activated Double Bonds—A New Synthetic Approach Hermann Stetter · Angewandte Chemie International Edition in English Nov 1976 617
43 Mechanisms of resistance to EGFR tyrosine kinase inhibitors Lihua Huang, Liwu Fu · Acta Pharmaceutica Sinica B Open access 26 Jul 2015 603
44 Quinoline, quinazoline and acridone alkaloids Joseph P. Michael · Natural Product Reports 2005 596
45 Viral myb oncogene encodes a sequence-specific DNA-binding activity Horst Biedenkapp, Uwe Borgmeyer, Albrecht E. Sippel et al. · Nature Oct 1988 596
46 Deregulated Akt3 Activity Promotes Development of Malignant Melanoma Jill M. Stahl, Arati K. Sharma, Mitchell Cheung et al. · Cancer Research Oct 2004 590
47 Targeting autophagy potentiates tyrosine kinase inhibitor–induced cell death in Philadelphia chromosome–positive cells, including primary CML stem cells Cristian Bellodi et al. · Journal of Clinical Investigation Open access 14 Apr 2009 571
48 Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer Hiroyuki Yasuda et al. · Science Translational Medicine Open access 18 Dec 2013 571
49 Studies leading to the identification of ZD1839 (iressa™): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer Andrew J Barker, Keith H. Gibson, Walter Grundy et al. · Bioorganic & Medicinal Chemistry Letters Open access Jul 2001 570
50 Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons Elzbieta Chalecka-Franaszek, De‐Maw Chuang · Proceedings of the National Academy of Sciences Open access 20 Jul 1999 545

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.