Most cited papers in Receptor Mechanisms and Signaling
What are the most cited papers in Receptor Mechanisms and Signaling?
The most cited paper in Receptor Mechanisms and Signaling is "Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction" (Yung-Chi Cheng, William H. Prusoff, 1973), with 12,981 citations. Next come "A novel potent vasoconstrictor peptide produced by vascular endothelial cells" (10,827) and "Enzymatic Determination of Total Serum Cholesterol" (9,199).
Showing 50 of 100 papers. Every paper with more than 1,863 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology | Dec 1973 | 12,981 |
| 2 | A novel potent vasoconstrictor peptide produced by vascular endothelial cells Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura et al. · Nature | Mar 1988 | 10,827 |
| 3 | Enzymatic Determination of Total Serum Cholesterol Charles C. Allain, Lucy S Poon, Cicely S G Chan et al. · Clinical Chemistry | Apr 1974 | 9,199 |
| 4 | LIGAND: A versatile computerized approach for characterization of ligand-binding systems Peter J. Munson, David Rodbard · Analytical Biochemistry | Sep 1980 | 8,497 |
| 5 | Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand Complexes Richard A. Friesner, Robert B. Murphy, Matthew P. Repasky et al. · Journal of Medicinal Chemistry | 23 Sep 2006 | 7,025 |
| 6 | The nuclear receptor superfamily: The second decade David J. Mangelsdorf, Carl S. Thummel, Miguel Beato et al. · Cell | Dec 1995 | 7,017 |
| 7 | Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat Sharon Pellow, Philippe Chopin, Sandra E. File et al. · Journal of Neuroscience Methods | Aug 1985 | 5,844 |
| 8 | The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions Irving I. Gottesman, Todd D. Gould · American Journal of Psychiatry | 31 Mar 2003 | 5,667 |
| 9 | Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor Krzysztof Palczewski, Takashi Kumasaka, Tetsuya Hori et al. · Science | 4 Aug 2000 | 5,661 |
| 10 | Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2 Renhong Yan, Yuanyuan Zhang, Yaning Li et al. · Science | 4 Mar 2020 | 5,612 |
| 11 | Glide: A New Approach for Rapid, Accurate Docking and Scoring. 2. Enrichment Factors in Database Screening Thomas A. Halgren, Robert B. Murphy, Richard A. Friesner et al. · Journal of Medicinal Chemistry | 27 Feb 2004 | 5,338 |
| 12 | Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region Klaus‐Peter Lesch, Dietmar Bengel, Armin Heils et al. · Science | 29 Nov 1996 | 5,207 |
| 13 | Receptive fields of single neurones in the cat's striate cortex David Hunter Hubel, T. N. Wiesel · The Journal of Physiology | Oct 1959 | 4,756 |
| 14 | AN INTEGRATIVE THEORY OF LOCUS COERULEUS-NOREPINEPHRINE FUNCTION: Adaptive Gain and Optimal Performance Gary Aston‐Jones, Jonathan D. Cohen · Annual Review of Neuroscience | 20 Jul 2005 | 4,723 |
| 15 | Predictive Reward Signal of Dopamine Neurons Wolfram Schultz · Journal of Neurophysiology | Jul 1998 | 4,658 |
| 16 | Depression: a new animal model sensitive to antidepressant treatments Roger D. Porsolt, Manuel Pichon, Maurice Jalfre · Nature | Apr 1977 | 4,476 |
| 17 | What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Kent C. Berridge, Terry E. Robinson · Brain Research Reviews | Dec 1998 | 4,184 |
| 18 | LTP and LTD Robert C. Malenka, Mark F. Bear · Neuron | Sep 2004 | 4,025 |
| 19 | Cloned Glutamate Receptors Michael Hollmann, Stephen F. Heinemann · Annual Review of Neuroscience | Mar 1994 | 3,994 |
| 20 | AKT/PKB Signaling: Navigating the Network Brendan D. Manning, Alex Toker · Cell | Apr 2017 | 3,862 |
| 21 | Identification of two related pentapeptides from the brain with potent opiate agonist activity Joel W. Hughes, Terry Smith, Hans Walter Kosterlitz et al. · Nature | Dec 1975 | 3,808 |
| 22 | Neurobiology of addiction: a neurocircuitry analysis George F. Koob, Nora D. Volkow · The Lancet Psychiatry | 27 Jul 2016 | 3,777 |
| 23 | Multiple receptors for dopamine John W. Kebabian, Donald B. Calne · Nature | 1979 | 3,750 |
| 24 | Dopamine Receptors: From Structure to Function Cristina Missale, Stuart Nash, Susan W. Robinson et al. · Physiological Reviews | 1998 | 3,654 |
| 25 | Developmental and regional expression in the rat brain and functional properties of four NMDA receptors Hannah Monyer, Nail Burnashev, David Laurie et al. · Neuron | Mar 1994 | 3,522 |
| 26 | THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE Joseph J. Schildkraut · American Journal of Psychiatry | Nov 1965 | 3,511 |
| 27 | High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor Vadim Cherezov, Daniel M. Rosenbaum, Michael A. Hanson et al. · Science | 25 Oct 2007 | 3,296 |
| 28 | The Adolescent Brain Betty Jo Casey, Rebecca Merrill Jones, Todd Anthony Hare · Annals of the New York Academy of Sciences | Mar 2008 | 3,289 |
| 29 | Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks L. Arthur Campfield, Françoise J. Smith, Yves Guisez et al. · Science | 28 Jul 1995 | 3,280 |
| 30 | Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation Hong Tian Wang, Man Yu, Mahendar Ochani et al. · Nature | 22 Dec 2002 | 3,242 |
| 31 | A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9 Mary Donoghue, F. Hsieh, Elizabeth Baronas et al. · Circulation Research | Sep 2000 | 3,177 |
| 32 | Glycine potentiates the NMDA response in cultured mouse brain neurons John William Johnson, Philippe Ascher · Nature | Feb 1987 | 3,160 |
| 33 | [19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors Juan Antonio Ballesteros‐Cánovas, Harel Weinstein · Methods in neurosciences | 1995 | 3,112 |
| 34 | Crystal structure of the β2 adrenergic receptor–Gs protein complex Søren G. F. Rasmussen, Brian T. DeVree, Yaozhong Zou et al. · Nature | 19 Jul 2011 | 3,103 |
| 35 | PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS P. Jeffrey Conn, Jean‐Philippe Pin · The Annual Review of Pharmacology and Toxicology | Apr 1997 | 3,092 |
| 36 | Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation Thien-Khai H. Vu, David T. Hung, Virginia I. Wheaton et al. · Cell | Mar 1991 | 3,007 |
| 37 | Drug Addiction, Dysregulation of Reward, and Allostasis G F Koob · Neuropsychopharmacology | Feb 2001 | 2,979 |
| 38 | The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints Robert Fredriksson, Malin Charlotta Lagerström, Lars‐Gustav Lundin et al. · Molecular Pharmacology | 21 May 2003 | 2,969 |
| 39 | RAG-1-deficient mice have no mature B and T lymphocytes Peter Mombaerts, John Iacomini, Randall S. Johnson et al. · Cell | Mar 1992 | 2,963 |
| 40 | The Physiology, Signaling, and Pharmacology of Dopamine Receptors Jean‐Martin Beaulieu, Raul R. Gainetdinov · Pharmacological Reviews | 15 Feb 2011 | 2,809 |
| 41 | Trends in GPCR drug discovery: new agents, targets and indications Alexander S. Hauser, Misty M. Attwood, Mathias Rask‐Andersen et al. · Nature Reviews Drug Discovery | 27 Oct 2017 | 2,779 |
| 42 | Seven-transmembrane receptors Kristen L. Pierce, Richard T. Premont, Robert J. Lefkowitz · Nature Reviews Molecular Cell Biology | Sep 2002 | 2,739 |
| 43 | NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory Steven E. Hyman, Robert C. Malenka, Eric J. Nestler · Annual Review of Neuroscience | 7 Apr 2006 | 2,676 |
| 44 | Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics Pierre Sokoloff, Bruno Giros, Marie‐Pascale Martres et al. · Nature | Sep 1990 | 2,633 |
| 45 | AMPA Receptor Trafficking and Synaptic Plasticity Roberto Malinow, Robert C. Malenka · Annual Review of Neuroscience | Mar 2002 | 2,622 |
| 46 | Getting Formal with Dopamine and Reward Wolfram Schultz · Neuron | Oct 2002 | 2,611 |
| 47 | Cloning and expression of a cDNA encoding an endothelin receptor Hiroshi Arai, Seiji Hori, Ichiro Aramori et al. · Nature | Dec 1990 | 2,597 |
| 48 | The structure and function of G-protein-coupled receptors Daniel M. Rosenbaum, Søren G. F. Rasmussen, Brian K. Kobilka · Nature | May 2009 | 2,595 |
| 49 | A model for receptor-regulated calcium entry James W. Putney · Cell Calcium | Feb 1986 | 2,579 |
| 50 | International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors Bertil B. Fredholm, Adriaan P. IJzerman, Kenneth A. Jacobson et al. · Pharmacological Reviews | Dec 2001 | 2,575 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.