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Topic · Molecular Biology

Receptor Mechanisms and Signaling

Receptor Mechanisms and Signaling is a research topic within Molecular Biology. Science Explorer counts 88k research works in it since 1950. 9.8% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the structure, function, and signaling mechanisms of G protein-coupled receptors (GPCRs), with a focus on crystal structures, signal transduction, arrestin-mediated pathways, pharmacology, drug discovery, receptor activation, biased signaling, and the molecular mechanisms involved. The research covers a wide range of topics related to GPCRs and their implications in various biological processes.

  • Crystal Structure
  • G-Protein-Coupled Receptors
  • Signal Transduction
  • Arrestin
  • Pharmacology
  • Drug Discovery
  • Receptor Activation
  • Biased Signaling
  • Cell Signaling
  • Molecular Mechanisms
Research works
88k
fractional, since 1950
In the world top 10%
8.7k
per year above
Top-10% rate
9.8%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-16%
the tick is no change
Largest producer
United States
43% of the 10 largest, 2022-now
Receptor Mechanisms and Signaling

Which countries lead Receptor Mechanisms and Signaling research?

By volume, the United States and China publish the most (2.1k and 953 works in 2022-now).

By volume, 2022-now

  1. 1 United States 2.1k works
  2. 2 China 953 works
  3. 3 Germany 335 works
  4. 4 Japan 317 works
  5. 5 United Kingdom 250 works
  6. 6 India 220 works
  7. 7 France 177 works
  8. 8 Italy 174 works
  9. 9 Canada 155 works
  10. 10 South Korea 118 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 43.3%China: 20.0%Germany: 7.0%Japan: 6.6%6 others listed: 23.0%43%largest
United States2,065 · 43.3%China953 · 20.0%Germany335 · 7.0%Japan317 · 6.6%6 others listed1,095 · 23.0%

Shares of the rows listed above, not of the whole node.

Which institutions lead Receptor Mechanisms and Signaling research?

By volume in 2022-now, National Institutes of Health publishes the most Receptor Mechanisms and Signaling research, followed by University of North Carolina at Chapel Hill and Centre National de la Recherche Scientifique.

By volume, 2022-now

  1. 1 National Institutes of HealthUnited States 79 works
  2. 2 University of North Carolina at Chapel HillUnited States 71 works
  3. 3 Centre National de la Recherche ScientifiqueFrance 62 works
  4. 4 Chinese Academy of SciencesChina 55 works
  5. 5 Russian Academy of SciencesRussia 45 works
  6. 6 Vanderbilt UniversityUnited States 43 works
  7. 7 Harvard UniversityUnited States 42 works
  8. 8 University of MichiganUnited States 37 works
  9. 9 InsermFrance 32 works
  10. 10 University of California, DavisUnited States 31 works

Who are the leading researchers in Receptor Mechanisms and Signaling?

The most-cited researchers publishing on Receptor Mechanisms and Signaling include George Davey Smith, Peer Bork and Richard M. Ryan.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Peer Bork Germany 396k citations
  3. 3 Richard M. Ryan United States 395k citations
  4. 4 John J.V. McMurray United Kingdom 349k citations
  5. 5 Shizuo Akira Japan 342k citations
  6. 6 Jun Wang China 340k citations
  7. 7 Giuseppe Remuzzi Italy 328k citations
  8. 8 John P. A. Ioannidis United States 317k citations
  9. 9 Gregory Y.H. Lip United Kingdom 311k citations
  10. 10 Karl John Friston United Kingdom 310k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Receptor Mechanisms and Signaling?

The most cited paper in Receptor Mechanisms and Signaling is "Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction" (Yung-Chi Cheng, William H. Prusoff, 1973), with 12,981 citations. Next come "A novel potent vasoconstrictor peptide produced by vascular endothelial cells" (10,827) and "Enzymatic Determination of Total Serum Cholesterol" (9,199).

Most cited papers
#PaperReleasedCitations
1 Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology Dec 1973 12,981
2 A novel potent vasoconstrictor peptide produced by vascular endothelial cells Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura et al. · Nature Open access Mar 1988 10,827
3 Enzymatic Determination of Total Serum Cholesterol Charles C. Allain, Lucy S Poon, Cicely S G Chan et al. · Clinical Chemistry Open access Apr 1974 9,199
4 LIGAND: A versatile computerized approach for characterization of ligand-binding systems Peter J. Munson, David Rodbard · Analytical Biochemistry Sep 1980 8,497
5 Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand Complexes Richard A. Friesner, Robert B. Murphy, Matthew P. Repasky et al. · Journal of Medicinal Chemistry 23 Sep 2006 7,025
All 100 most cited papers, with filters and sorting

Where is Receptor Mechanisms and Signaling research done?

The largest centres of Receptor Mechanisms and Signaling research in 2022-now are Beijing (China), Shanghai (China), New York (United States) and Tokyo (Japan). Among places with at least 20 works in it, it is an unusually large share of all research in Bethesda, Nashville and Davis.

Largest cities, 2022-now

  1. 1 BeijingChina 153 works
  2. 2 ShanghaiChina 116 works
  3. 3 New YorkUnited States 106 works
  4. 4 TokyoJapan 93 works
  5. 5 ParisFrance 82 works
  6. 6 BethesdaUnited States 75 works
  7. 7 Chapel HillUnited States 71 works
  8. 8 PhiladelphiaUnited States 64 works
  9. 9 LondonUnited Kingdom 59 works
  10. 10 SeoulSouth Korea 57 works

Where it is the local speciality

  1. BethesdaUS · 75.4 works10×
  2. NashvilleUS · 49.7 works8.9×
  3. DavisUS · 31.1 works7.0×
  4. Chapel HillUS · 70.5 works6.5×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Receptor Mechanisms and Signaling than the world average.

See Receptor Mechanisms and Signaling on the map

Where is the best place to study Receptor Mechanisms and Signaling?

Among universities, judged by research, ShanghaiTech University, Stanford University and University of Chinese Academy of Sciences score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 17.89%fractional works in this field (log) →share of work in the world top 10% →University of Chines…ShanghaiTech Univers…Stanford UniversityHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1ShanghaiTech UniversityChina 69.826.5%13.6×13 +43.3%
2Stanford UniversityUnited States 68.524.4%3.3×26 +5.2%
3University of Chinese Academy of SciencesChina 60.528.1%1.8×16 +34.3%
4Harvard UniversityUnited States 57.016.4%2.5×42 -22.0%
5Peking UniversityChina 53.519.7%2.7×29 +17.2%
6Duke UniversityUnited States 51.811.3%4.8×21 -2.0%
7University of California, DavisUnited States 51.79.1%7.4×31 +34.2%
8University of North Carolina at Chapel HillUnited States 51.17.0%7.5×71 -44.6%
9Rockefeller UniversityUnited States 51.118.1%37.8×12 +11.0%
10Zhejiang UniversityChina 50.818.3%1.6×22 +27.7%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Receptor Mechanisms and Signaling, country by country

Is Receptor Mechanisms and Signaling research growing?

Output in 2022-2025 was 16% lower than in 2018-2021, peaking in 2008.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Receptor Mechanisms and Signaling as a percentage of every work published that year, 0.025% in 2024.

still counting0.10%0.20%0.30%Receptor Mechanisms and Signaling0.023% in 202519801990200020102020

Fractional works of Receptor Mechanisms and Signaling over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Receptor Mechanisms and Signaling10.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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