Most cited papers in Redox biology and oxidative stress
What are the most cited papers in Redox biology and oxidative stress?
The most cited paper in Redox biology and oxidative stress is "Free radicals and antioxidants in normal physiological functions and human disease" (Marián Valko, Dieter Leibfritz, Ján Moncóľ et al., 2006), with 14,300 citations. Next come "Superoxide Dismutase" (12,906) and "Free Radicals in the Physiological Control of Cell Function" (9,887).
Showing 50 of 100 papers. Every paper with more than 1,429 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Free radicals and antioxidants in normal physiological functions and human disease Marián Valko, Dieter Leibfritz, Ján Moncóľ et al. · The International Journal of Biochemistry & Cell Biology | 7 Aug 2006 | 14,300 |
| 2 | Superoxide Dismutase Joe M. McCord, Irwin Fridovich · Journal of Biological Chemistry | Nov 1969 | 12,906 |
| 3 | Free Radicals in the Physiological Control of Cell Function Wulf Dröge · Physiological Reviews | 2002 | 9,887 |
| 4 | How mitochondria produce reactive oxygen species Michael P. Murphy · Biochemical Journal | 12 Dec 2008 | 8,245 |
| 5 | Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Joseph S. Beckman, ThomasJ Beckman, Jake Y. Chen et al. · Proceedings of the National Academy of Sciences | Feb 1990 | 7,073 |
| 6 | ROS Function in Redox Signaling and Oxidative Stress Michael Schieber, Navdeep S. Chandel · Current Biology | May 2014 | 6,967 |
| 7 | Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Dunyaporn Trachootham, Jérôme Alexandre, Peng Huang · Nature Reviews Drug Discovery | 29 May 2009 | 5,449 |
| 8 | Reactive oxygen species (ROS) as pleiotropic physiological signalling agents Helmut Sies, Dean P. Jones · Nature Reviews Molecular Cell Biology | 30 Mar 2020 | 5,273 |
| 9 | Oxyl radicals, redox-sensitive signalling cascades and antioxidants Marcelo Genestra · Cellular Signalling | 2 May 2007 | 4,791 |
| 10 | Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine Owen W. Griffith · Analytical Biochemistry | Jul 1980 | 4,625 |
| 11 | Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple Freya Q. Schafer, Garry R. Buettner · Free Radical Biology and Medicine | Jun 2001 | 4,588 |
| 12 | Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling Paul D. Ray, Bowen Huang, Yoshiaki Tsuji · Cellular Signalling | 20 Jan 2012 | 4,423 |
| 13 | Mitochondrial formation of reactive oxygen species Julio F. Turrens · The Journal of Physiology | Oct 2003 | 3,949 |
| 14 | The Free Radical Theory of Aging Matures Kenneth B. Beckman, Bruce N. Ames · Physiological Reviews | Apr 1998 | 3,892 |
| 15 | Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway Thomas W. Kensler, Nobunao Wakabayashi, Shyam S. Biswal · The Annual Review of Pharmacology and Toxicology | 29 Aug 2006 | 3,654 |
| 16 | ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis Benoît D’Autréaux, Michel B. Tolédano · Nature Reviews Molecular Cell Biology | 12 Sep 2007 | 3,648 |
| 17 | Modulation of oxidative stress as an anticancer strategy Chiara Gorrini, Isaac S. Harris, Tak W. Mak · Nature Reviews Drug Discovery | 29 Nov 2013 | 3,620 |
| 18 | Oxidative Stress Helmut Sies, Carsten Berndt, Dean P. Jones · Annual Review of Biochemistry | 25 Apr 2017 | 3,524 |
| 19 | Reactive oxygen species in cancer Geou‐Yarh Liou, Peter Störz · Free Radical Research | 2010 | 3,440 |
| 20 | Reactive oxygen species, cellular redox systems, and apoptosis Magdalena L. Circu, Tak Yee Aw · Free Radical Biology and Medicine | 5 Jan 2010 | 3,360 |
| 21 | Protein Oxidation in Aging, Disease, and Oxidative Stress Barbara S. Berlett, Earl R. Stadtman · Journal of Biological Chemistry | Aug 1997 | 3,338 |
| 22 | Oxidative stress: a concept in redox biology and medicine Helmut Sies · Redox Biology | 2 Jan 2015 | 3,026 |
| 23 | Reactive oxygen species in cell signaling Victor John Thannickal, Barry L. Fanburg · American Journal of Physiology-Lung Cellular and Molecular Physiology | Dec 2000 | 2,932 |
| 24 | The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies Celia Andrés, José Manuel Pérez de la Lastra, Francisco J. Plou et al. · International Journal of Molecular Sciences | 28 Apr 2021 | 2,768 |
| 25 | [37] Carbonyl assays for determination of oxidatively modified proteins Rodney L. Levine, Joy A. Williams, Earl P. Stadtman et al. · Methods in enzymology on CD-ROM/Methods in enzymology | 1994 | 2,710 |
| 26 | A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells Jiahuai Han, Jeffrey D. Lee, L. Bibbs et al. · Science | 5 Aug 1994 | 2,670 |
| 27 | Structure, mechanism and regulation of peroxiredoxins Zachary A. Wood, Ewald Schröder, J. Robin Harris et al. · Trends in Biochemical Sciences | 2003 | 2,553 |
| 28 | Physiological functions of thioredoxin and thioredoxin reductase Elias S.J. Arnér, Arne Holmgren · European Journal of Biochemistry | Oct 2000 | 2,553 |
| 29 | Production of large amounts of hydrogen peroxide by human tumor cells. Ted P. Szatrowski, Carl Nathan · PubMed | Feb 1991 | 2,519 |
| 30 | Reconciling the chemistry and biology of reactive oxygen species Christine C. Winterbourn · Nature Chemical Biology | 17 Apr 2008 | 2,512 |
| 31 | [38] Oxidative damage to proteins: Spectrophotometric method for carbonyl assay Abraham Zeev Reznick, Lester Packer · Methods in enzymology on CD-ROM/Methods in enzymology | 1994 | 2,462 |
| 32 | Calmodulin Plays a Pivotal Role in Cellular Regulation Wai Yiu Cheung · Science | 4 Jan 1980 | 2,444 |
| 33 | Reactive Species and Antioxidants. Redox Biology Is a Fundamental Theme of Aerobic Life Barry B. Halliwell · PLANT PHYSIOLOGY | Jun 2006 | 2,396 |
| 34 | Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1 Masao Saitoh, Hideki Nishitoh, Makiko Fujii et al. · The EMBO Journal | May 1998 | 2,396 |
| 35 | Protein carbonyl groups as biomarkers of oxidative stress Isabella Dalle‐Donne, Ranieri Rossi, Daniela Giustarini et al. · Clinica Chimica Acta | 17 Feb 2003 | 2,366 |
| 36 | Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways Hidenori Ichijo, Eisuke Nishida, Kenji Irie et al. · Science | 3 Jan 1997 | 2,336 |
| 37 | Signal transduction by reactive oxygen species Toren Finkel · The Journal of Cell Biology | 11 Jul 2011 | 2,331 |
| 38 | Cellular response to oxidative stress: Signaling for suicide and survival* Jennifer L. Martindale, Nikki J. Holbrook · Journal of Cellular Physiology | 24 May 2002 | 2,327 |
| 39 | ROS signaling: the new wave? Ron Mittler, Sandy Vanderauwera, Nobuhiro Suzuki et al. · Trends in Plant Science | 15 Apr 2011 | 2,327 |
| 40 | Transcriptional Regulation by Nrf2 Claudia Tonelli, Iok In Christine Chio, David Arthur Tuveson · Antioxidants and Redox Signaling | 20 Oct 2017 | 2,248 |
| 41 | Pathways of Oxidative Damage James A. Imlay · Annual Review of Microbiology | Oct 2003 | 2,247 |
| 42 | Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Barry B. Halliwell, Matthew Whiteman · British Journal of Pharmacology | May 2004 | 2,234 |
| 43 | Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling Ying Wang, Robyn S. Branicky, Alycia Noë et al. · The Journal of Cell Biology | 18 Apr 2018 | 2,219 |
| 44 | ROS in cancer therapy: the bright side of the moon Bruno Perillo, Marzia Di Donato, Antonio Pezone et al. · Experimental & Molecular Medicine | Feb 2020 | 2,203 |
| 45 | Oxidative stress as a mediator of apoptosis Thomas M. Buttke, Paul A. Sandstrom · Immunology Today | 1994 | 2,199 |
| 46 | Glutathione synthesis Shelly Chi-Loo Lu · Biochimica et Biophysica Acta (BBA) - General Subjects | 17 Sep 2012 | 2,197 |
| 47 | H 2 O 2 , a Necessary Evil for Cell Signaling Sue Goo Rhee · Science | 30 Jun 2006 | 2,179 |
| 48 | Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress Helmut Sies · Redox Biology | 6 Jan 2017 | 2,177 |
| 49 | Protein S-nitrosylation: purview and parameters Douglas T. Hess, Akio Matsumoto, Sung-Oog Kim et al. · Nature Reviews Molecular Cell Biology | Feb 2005 | 2,155 |
| 50 | Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species Long He, Ting He, Shabnam Farrar et al. · Cellular Physiology and Biochemistry | 2017 | 2,147 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.