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Topic · Molecular Biology

Redox biology and oxidative stress

Redox biology and oxidative stress is a research topic within Molecular Biology. Science Explorer counts 13k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the role of reactive oxygen species (ROS) and redox signaling in cellular processes, focusing on mechanisms of redox regulation, oxidative stress, and the involvement of antioxidant systems such as thioredoxin and peroxiredoxins. It delves into the signaling functions of hydrogen peroxide, glutathione catalysis, protein carbonylation, and the maintenance of cellular redox homeostasis.

  • Reactive Oxygen Species
  • Redox Regulation
  • Oxidative Stress
  • Thioredoxin System
  • Peroxiredoxins
  • Hydrogen Peroxide Signaling
  • Glutathione Catalysis
  • Protein Carbonylation
  • Cellular Redox Homeostasis
  • Sulfur and Selenium
Research works
13k
fractional, since 1950
In the world top 10%
1.3k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-3%
the tick is no change
Largest producer
China
40% of the 10 largest, 2022-now
Redox biology and oxidative stress

Which countries lead Redox biology and oxidative stress research?

By volume, China and the United States publish the most (579 and 350 works in 2022-now).

By volume, 2022-now

  1. 1 China 579 works
  2. 2 United States 350 works
  3. 3 India 88 works
  4. 4 Germany 86 works
  5. 5 Japan 85 works
  6. 6 Russia 63 works
  7. 7 South Korea 61 works
  8. 8 United Kingdom 52 works
  9. 9 Italy 45 works
  10. 10 France 44 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 39.9%United States: 24.1%India: 6.1%Germany: 5.9%6 others listed: 24.1%40%largest
China579 · 39.9%United States350 · 24.1%India88 · 6.1%Germany86 · 5.9%6 others listed350 · 24.1%

Shares of the rows listed above, not of the whole node.

Which institutions lead Redox biology and oxidative stress research?

By volume in 2022-now, Russian Academy of Sciences publishes the most Redox biology and oxidative stress research, followed by Centre National de la Recherche Scientifique and Chinese Academy of Sciences.

By volume, 2022-now

  1. 1 Russian Academy of SciencesRussia 24 works
  2. 2 Centre National de la Recherche ScientifiqueFrance 19 works
  3. 3 Chinese Academy of SciencesChina 16 works
  4. 4 Universidade de São PauloBrazil 13 works
  5. 5 Harvard UniversityUnited States 12 works
  6. 6 Universidad de la República de UruguayUruguay 11 works
  7. 7 Consejo Superior de Investigaciones CientíficasSpain 10 works
  8. 8 National Institutes of HealthUnited States 9 works
  9. 9 Shanghai Jiao Tong UniversityChina 9 works
  10. 10 Sichuan UniversityChina 9 works

Who are the leading researchers in Redox biology and oxidative stress?

The most-cited researchers publishing on Redox biology and oxidative stress include Guido Kroemer, Gordon Brent Mills and Ben Zhong Tang.

  1. 1 Guido Kroemer France 386k citations
  2. 2 Gordon Brent Mills United States 265k citations
  3. 3 Ben Zhong Tang China 261k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Redox biology and oxidative stress?

The most cited paper in Redox biology and oxidative stress is "Free radicals and antioxidants in normal physiological functions and human disease" (Marián Valko, Dieter Leibfritz, Ján Moncóľ et al., 2006), with 14,300 citations. Next come "Superoxide Dismutase" (12,906) and "Free Radicals in the Physiological Control of Cell Function" (9,887).

Most cited papers
#PaperReleasedCitations
1 Free radicals and antioxidants in normal physiological functions and human disease Marián Valko, Dieter Leibfritz, Ján Moncóľ et al. · The International Journal of Biochemistry & Cell Biology 7 Aug 2006 14,300
2 Superoxide Dismutase Joe M. McCord, Irwin Fridovich · Journal of Biological Chemistry Open access Nov 1969 12,906
3 Free Radicals in the Physiological Control of Cell Function Wulf Dröge · Physiological Reviews Review 2002 9,887
4 How mitochondria produce reactive oxygen species Michael P. Murphy · Biochemical Journal Open access 12 Dec 2008 8,245
5 Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Joseph S. Beckman, ThomasJ Beckman, Jake Y. Chen et al. · Proceedings of the National Academy of Sciences Open access Feb 1990 7,073
All 100 most cited papers, with filters and sorting

Where is Redox biology and oxidative stress research done?

The largest centres of Redox biology and oxidative stress research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Nanjing (China).

Largest cities, 2022-now

  1. 1 BeijingChina 63 works
  2. 2 ShanghaiChina 36 works
  3. 3 GuangzhouChina 28 works
  4. 4 NanjingChina 26 works
  5. 5 WuhanChina 25 works
  6. 6 MoscowRussia 24 works
  7. 7 TokyoJapan 22 works
  8. 8 ParisFrance 20 works
  9. 9 HangzhouChina 19 works
  10. 10 São PauloBrazil 19 works
See Redox biology and oxidative stress on the map

Where is the best place to study Redox biology and oxidative stress?

Among universities, judged by research, Universidad de la República de Uruguay, Harvard University and Sichuan University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 13.91%fractional works in this field (log) →share of work in the world top 10% →Sichuan UniversityHarvard UniversityUniversidad de la Re…Universidade de São …
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Universidad de la República de UruguayUruguay 68.211.4%26.2×11 +42.3%
2Harvard UniversityUnited States 67.617.3%2.3×12 +2.8%
3Sichuan UniversityChina 56.730.0%2.4×9 +66.9%
4Universidade de São PauloBrazil 45.83.7%3.9×13 +9.2%
5McGill UniversityCanada 39.312.8%5.2×9 -14.6%
6Lanzhou UniversityChina 36.912.9%7.5×9 -11.2%
7Central South UniversityChina 31.715.8%2.7×8 +53.3%
8Shanghai Jiao Tong UniversityChina 28.012.7%1.9×9 +12.5%
9Sun Yat-sen UniversityChina 19.116.7%2.4×8 -43.3%
10Nanjing Medical UniversityChina 9.05.8%5.5×8 -11.0%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Redox biology and oxidative stress, country by country

Is Redox biology and oxidative stress research growing?

Output in 2022-2025 was 3% lower than in 2018-2021, peaking in 2025.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Redox biology and oxidative stress as a percentage of every work published that year, 0.0069% in 2024.

still counting0.010%0.020%0.030%Redox biology and oxidative stress0.0080% in 202519801990200020102020

Fractional works of Redox biology and oxidative stress over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Redox biology and oxidative stress10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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