Topic · Renin-Angiotensin System Studies
Most cited papers in Renin-Angiotensin System Studies
What are the most cited papers in Renin-Angiotensin System Studies?
The most cited paper in Renin-Angiotensin System Studies is "A novel potent vasoconstrictor peptide produced by vascular endothelial cells" (Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura et al., 1988), with 10,827 citations. Next come "The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure" (9,197) and "Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients" (8,696).
Showing 50 of 99 papers. Every paper with more than 1,085 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | A novel potent vasoconstrictor peptide produced by vascular endothelial cells Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura et al. · Nature | Mar 1988 | 10,827 |
| 2 | The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure Bertram Pitt, Faiez M. Zannad, Willem J. Remme et al. · New England Journal of Medicine | 2 Sep 1999 | 9,197 |
| 3 | Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients The Heart Outcomes Prevention Evaluation Study Investigators · New England Journal of Medicine | 20 Jan 2000 | 8,696 |
| 4 | Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure John J.V. McMurray, Milton Packer, Akshay Suvas Desai et al. · New England Journal of Medicine | 30 Aug 2014 | 6,982 |
| 5 | Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly Joseph S. Beckman, Willem Hendrik Koppenol · American Journal of Physiology-Cell Physiology | Nov 1996 | 5,539 |
| 6 | Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol Björn Dahlöf, Richard B. Devereux, Sverre Erik Kjeldsen et al. · The Lancet | Mar 2002 | 5,432 |
| 7 | Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region Klaus‐Peter Lesch, Dietmar Bengel, Armin Heils et al. · Science | 29 Nov 1996 | 5,207 |
| 8 | Vascular endothelial cells synthesize nitric oxide from L-arginine Richard M. J. Palmer, D. Ashton, Salvador Moncada · Nature | Jun 1988 | 4,797 |
| 9 | Nitric oxide synthases: regulation and function Ulrich Förstermann, William C. Sessa · European Heart Journal | Sep 2011 | 4,393 |
| 10 | Nitric oxide as a secretory product of mammalian cells Carl Nathan · The FASEB Journal | Sep 1992 | 4,392 |
| 11 | Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidant Stress Hua “Linda” Cai, David Glenn Harrison · Circulation Research | 10 Nov 2000 | 3,832 |
| 12 | Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation Stefanie Dimmeler, Ingrid Fleming, Beate Fißlthaler et al. · Nature | Jun 1999 | 3,605 |
| 13 | A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9 Mary Donoghue, F. Hsieh, Elizabeth Baronas et al. · Circulation Research | Sep 2000 | 3,177 |
| 14 | A Randomized Trial of the Angiotensin-Receptor Blocker Valsartan in Chronic Heart Failure Jay N. Cohn, Gianni Tognoni · New England Journal of Medicine | 6 Dec 2001 | 3,116 |
| 15 | Treatment of Hypertension in Patients 80 Years of Age or Older Nigel S Beckett, Ruth K Peters, ASTRID E. FLETCHER et al. · New England Journal of Medicine | 31 Mar 2008 | 3,112 |
| 16 | Nitric oxide: an endogenous modulator of leukocyte adhesion. Paul Kubes, Motohisa Suzuki, D. Neil Granger · Proceedings of the National Academy of Sciences | Jun 1991 | 3,055 |
| 17 | Nitric oxide synthases in mammals Richard G. Knowles, Salvador Moncada · Biochemical Journal | Mar 1994 | 2,772 |
| 18 | Regulation of endothelium-derived nitric oxide production by the protein kinase Akt David J. Fulton, Jean‐Philippe Gratton, Timothy J. D. McCabe et al. · Nature | 10 Jun 1999 | 2,624 |
| 19 | Angiotensin-converting enzyme 2 protects from severe acute lung failure Yumiko Imai, Keiji Kuba, Shuan Rao et al. · Nature | 6 Jul 2005 | 2,566 |
| 20 | Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. Sanjay Rajagopalan, Stephan Dominik Kurz, Thomas Münzel et al. · Journal of Clinical Investigation | 15 Apr 1996 | 2,463 |
| 21 | Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor Takeshi Sakurai, Masashi Yanagisawa, Yoh Takuwat et al. · Nature | Dec 1990 | 2,442 |
| 22 | Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries Paul L. Ludmer, Andrew Peter Selwyn, Thomas Shook et al. · New England Journal of Medicine | 23 Oct 1986 | 2,430 |
| 23 | Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials F. Turnbull · The Lancet | Nov 2003 | 2,428 |
| 24 | Application of a Radioimmunoassay for Angiotensin I to the Physiologic Measurements of Plasma Renin Activity in Normal Human Subjects1 Edgar Haber, THERESA KOERNER, Lot B. Page et al. · The Journal of Clinical Endocrinology & Metabolism | Oct 1969 | 2,249 |
| 25 | Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19 Muthiah Vaduganathan, Orly Vardeny, Thomas M. Michel et al. · New England Journal of Medicine | 30 Mar 2020 | 2,174 |
| 26 | International Union of Pharmacology. XXIII. The Angiotensin II Receptors Marc de Gasparo, Kevin J. Catt, Tadashi Inagami et al. · Pharmacological Reviews | Sep 2000 | 2,142 |
| 27 | Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure A. Leone, S. Moncada, Patrick J. Vallance et al. · The Lancet | Mar 1992 | 2,141 |
| 28 | Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk Georg Ehret et al. · Nature | 9 Sep 2011 | 2,085 |
| 29 | Hypertension in mice lacking the gene for endothelial nitric oxide synthase Paul Lee Huang, Zhihong Huang, Hiroshi L. Mashimo et al. · Nature | Sep 1995 | 2,081 |
| 30 | A Human Homolog of Angiotensin-converting Enzyme Sarah R. Tipnis, Nigel M. Hooper, Ralph Hyde et al. · Journal of Biological Chemistry | Oct 2000 | 2,047 |
| 31 | Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial Lennart Hansson, Lars Hjalmar Lindholm, LEO K. NISKANEN et al. · The Lancet | Feb 1999 | 2,017 |
| 32 | Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial—the Losartan Heart Failure Survival Study ELITE II Bertram Pitt, Philip Alexander Poole-Wilson, Robert Segal et al. · The Lancet | May 2000 | 1,964 |
| 33 | Heart Rate, Life Expectancy and the Cardiovascular System: Therapeutic Considerations Konstantinos Dean Boudoulas, JEFFREY S. BORER, Harisios K Boudoulas · Cardiology | 2015 | 1,944 |
| 34 | Endothelial Nitric Oxide Synthase in Vascular Disease Ulrich Förstermann, Thomas Münzel · Circulation | 3 Apr 2006 | 1,940 |
| 35 | Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction François Cambien, Odette Poirier, Laure Lecerf et al. · Nature | 15 Oct 1992 | 1,937 |
| 36 | Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system Puja K. Mehta, Kathy K. Griendling · American Journal of Physiology-Cell Physiology | 27 Jul 2006 | 1,929 |
| 37 | Non-Transgenic Mouse Models of Kidney Disease Michael Rabe, Franz S. Schaefer · The Nephron journals/Nephron journals | 2016 | 1,927 |
| 38 | Regulatory Functions of the Vascular Endothelium Franklin H. Epstein, John Robert Vane, Erik Änggård et al. · New England Journal of Medicine | 5 Jul 1990 | 1,902 |
| 39 | Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo Daryl D. Rees, Richard M. J. Palmer, Richard Schulz et al. · British Journal of Pharmacology | Nov 1990 | 1,865 |
| 40 | Molecular basis of human hypertension: Role of angiotensinogen Xavier Jeunemaı̂tre, Florent Soubrier, Yuri V. Kotelevtsev et al. · Cell | Oct 1992 | 1,861 |
| 41 | Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas Robson A.S. Santos, Ana Cristina Simões e Silva, Christine Maric et al. · Proceedings of the National Academy of Sciences | 26 Jun 2003 | 1,819 |
| 42 | Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials Blood Pressure Lowering Treatment Trialists' Collaboration · The Lancet | Dec 2000 | 1,792 |
| 43 | Angiotensin-converting enzyme 2 is an essential regulator of heart function Michael A. Crackower, Renu Sarao, Gavin Y. Oudit et al. · Nature | Jun 2002 | 1,775 |
| 44 | Physiology of Local Renin-Angiotensin Systems Martin Paul, Ali Poyan Mehr, Reinhold Kreutz · Physiological Reviews | 30 Jun 2006 | 1,747 |
| 45 | Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE) Bertram Pitt, Robert Segal, Felipe A Martinez et al. · The Lancet | Mar 1997 | 1,670 |
| 46 | Effect of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin-Converting Enzyme 2 Carlos Maria Ferrario, Jewell A. Jessup, Mark C. Chappell et al. · Circulation | 16 May 2005 | 1,618 |
| 47 | Long-term ACE-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: a systematic overview of data from individual patients Marcus D Flather, Salim Yusuf, Lars Køber et al. · The Lancet | May 2000 | 1,595 |
| 48 | The Emerging Concept of Vascular Remodeling Franklin H. Epstein, Gary H. Gibbons, Victor J. Dzau · New England Journal of Medicine | 19 May 1994 | 1,585 |
| 49 | Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase Zhihong Huang, Paul Lee Huang, Nariman Panahian et al. · Science | 23 Sep 1994 | 1,582 |
| 50 | Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism Paul Ursmar Milliez, Xavier J. Girerd, Pierre‐François Plouin et al. · Journal of the American College of Cardiology | Apr 2005 | 1,543 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.