Science Explorer Back to mapMap
Discussion
Topic · Cardiology and Cardiovascular Medicine

Renin-Angiotensin System Studies

Renin-Angiotensin System Studies is a research topic within Cardiology and Cardiovascular Medicine. Science Explorer counts 24k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the role of the Renin-Angiotensin System in cardiovascular physiology and pathology, focusing on the mechanisms of action, physiological effects, and pathological implications of components such as Angiotensin, Renin, ACE2, and Angiotensin II Receptors. It covers topics including hypertension, cardiovascular disease, inflammation, fibrosis, and the potential therapeutic interventions such as Aliskiren in conditions like diabetes.

  • Angiotensin
  • Renin
  • ACE2
  • Hypertension
  • Cardiovascular Disease
  • Inflammation
  • Angiotensin II Receptor
  • Fibrosis
  • Aliskiren
  • Diabetes
Research works
24k
fractional, since 1950
In the world top 10%
2.4k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-5%
the tick is no change
Largest producer
United States
35% of the 10 largest, 2022-now
Renin-Angiotensin System Studies

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Renin-Angiotensin System Studies research?

By volume, the United States and China publish the most (578 and 472 works in 2022-now).

By volume, 2022-now

  1. 1 United States 578 works
  2. 2 China 472 works
  3. 3 Japan 123 works
  4. 4 India 89 works
  5. 5 Germany 87 works
  6. 6 United Kingdom 80 works
  7. 7 Brazil 64 works
  8. 8 Italy 61 works
  9. 9 Canada 55 works
  10. 10 Russia 51 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 34.8%China: 28.5%Japan: 7.4%India: 5.3%6 others listed: 24.0%35%largest
United States578 · 34.8%China472 · 28.5%Japan123 · 7.4%India89 · 5.3%6 others listed398 · 24.0%

Shares of the rows listed above, not of the whole node.

Which institutions lead Renin-Angiotensin System Studies research?

By volume in 2022-now, Harvard University publishes the most Renin-Angiotensin System Studies research, followed by Medical College of Wisconsin and Tulane University.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 23 works
  2. 2 Medical College of WisconsinUnited States 14 works
  3. 3 Tulane UniversityUnited States 14 works
  4. 4 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 13 works
  5. 5 University of VirginiaUnited States 13 works
  6. 6 Russian Academy of SciencesRussia 13 works
  7. 7 Universidade de São PauloBrazil 12 works
  8. 8 Shanghai Jiao Tong UniversityChina 12 works
  9. 9 Peking UniversityChina 11 works
  10. 10 Johns Hopkins UniversityUnited States 10 works

Who are the leading researchers in Renin-Angiotensin System Studies?

The most-cited researchers publishing on Renin-Angiotensin System Studies include George Davey Smith, Mark J. Daly and John J.V. McMurray.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Mark J. Daly United States 403k citations
  3. 3 John J.V. McMurray United Kingdom 349k citations
  4. 4 Hermann Brenner Germany 343k citations
  5. 5 Emelia J. Benjamin United States 341k citations
  6. 6 Jun Wang China 340k citations
  7. 7 Giuseppe Remuzzi Italy 328k citations
  8. 8 Mika Kivimäki United Kingdom 318k citations
  9. 9 Graeme J. Hankey Australia 316k citations
  10. 10 Gregory Y.H. Lip United Kingdom 311k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Renin-Angiotensin System Studies?

The most cited paper in Renin-Angiotensin System Studies is "A novel potent vasoconstrictor peptide produced by vascular endothelial cells" (Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura et al., 1988), with 10,827 citations. Next come "The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure" (9,197) and "Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients" (8,696).

Most cited papers
#PaperReleasedCitations
1 A novel potent vasoconstrictor peptide produced by vascular endothelial cells Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura et al. · Nature Open access Mar 1988 10,827
2 The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure Bertram Pitt, Faiez M. Zannad, Willem J. Remme et al. · New England Journal of Medicine Open access 2 Sep 1999 9,197
3 Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients The Heart Outcomes Prevention Evaluation Study Investigators · New England Journal of Medicine Open access 20 Jan 2000 8,696
4 Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure John J.V. McMurray, Milton Packer, Akshay Suvas Desai et al. · New England Journal of Medicine Open access 30 Aug 2014 6,982
5 Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly Joseph S. Beckman, Willem Hendrik Koppenol · American Journal of Physiology-Cell Physiology Nov 1996 5,539
All 99 most cited papers, with filters and sorting

Where is Renin-Angiotensin System Studies research done?

The largest centres of Renin-Angiotensin System Studies research in 2022-now are Beijing (China), Shanghai (China), Tokyo (Japan) and Guangzhou (China).

Largest cities, 2022-now

  1. 1 BeijingChina 62 works
  2. 2 ShanghaiChina 36 works
  3. 3 TokyoJapan 31 works
  4. 4 GuangzhouChina 30 works
  5. 5 São PauloBrazil 26 works
  6. 6 LondonUnited Kingdom 24 works
  7. 7 BostonUnited States 21 works
  8. 8 SeoulSouth Korea 21 works
  9. 9 MoscowRussia 21 works
  10. 10 MelbourneAustralia 20 works
See Renin-Angiotensin System Studies on the map

Where is the best place to study Renin-Angiotensin System Studies?

Among universities, judged by research, Harvard University, Vanderbilt University and University of Virginia score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 13.15%fractional works in this field (log) →share of work in the world top 10% →Harvard UniversityVanderbilt UniversityTulane UniversityUniversity of Virginia
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 87.021.8%3.5×23 -6.3%
2Vanderbilt UniversityUnited States 52.116.6%5.8×8 +21.0%
3University of VirginiaUnited States 49.56.3%10.5×13 +36.3%
4Tulane UniversityUnited States 48.39.7%28.0×14 +4.2%
5University of BristolUnited Kingdom 46.110.4%8.2×9 +158.8%
6Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 44.212.9%6.2×13 +49.7%
7Peking UniversityChina 41.716.0%2.6×11 +35.7%
8Medical College of WisconsinUnited States 40.412.5%25.1×14 -13.1%
9Universidade Federal de Minas GeraisBrazil 36.315.8%5.6×8 -64.1%
10Shanghai Jiao Tong UniversityChina 33.79.5%2.1×12 +71.2%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Renin-Angiotensin System Studies, country by country

Is Renin-Angiotensin System Studies research growing?

Output in 2022-2025 was 5% lower than in 2018-2021, peaking in 2008.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Renin-Angiotensin System Studies as a percentage of every work published that year, 0.0083% in 2024.

still counting0.020%0.040%0.060%Renin-Angiotensin System Studies0.0093% in 202519801990200020102020

Fractional works of Renin-Angiotensin System Studies over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Renin-Angiotensin System Studies10.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Discussion

Ask a question or share a note about Renin-Angiotensin System Studies. Posts are plain text and can be reported.