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Most cited papers in S100 Proteins and Annexins

What are the most cited papers in S100 Proteins and Annexins?

The most cited paper in S100 Proteins and Annexins is "Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment." (Harold P. Adams, Birgitte H. Bendixen, L. Jaap Kappelle et al., 1993), with 12,468 citations. Next come "Interobserver agreement for the assessment of handicap in stroke patients." (6,579) and "Astrocyte–endothelial interactions at the blood–brain barrier" (5,649).

Showing 50 of 99 papers. Every paper with more than 1,007 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Harold P. Adams, Birgitte H. Bendixen, L. Jaap Kappelle et al. · Stroke Open access 1993 12,468
2 Interobserver agreement for the assessment of handicap in stroke patients. John Cornelis Van Swieten, Peter J. Koudstaal, Marieke C H de Visser et al. · Stroke Open access May 1988 6,579
3 Astrocyte–endothelial interactions at the blood–brain barrier N. Joan Abbott, Lars Rönnbäck, Elisabeth Hansson · Nature reviews. Neuroscience Review 21 Dec 2005 5,649
4 Classification of primary progressive aphasia and its variants Maria‐Luisa Gorno‐Tempini, Argye Elizabeth Hillis, Sandra Weıntraub et al. · Neurology Open access 16 Feb 2011 5,238
5 Reactive Oxygen Species in Inflammation and Tissue Injury Manish Mittal, Mohammad R. Siddiqui, Khiem A. Tran et al. · Antioxidants and Redox Signaling Open access 2 Sep 2013 4,933
6 Microglia-mediated neurotoxicity: uncovering the molecular mechanisms Michelle L. Block, Luigi Zecca, Jau‐Shyong Hong · Nature reviews. Neuroscience Review 20 Dec 2006 4,164
7 Pathobiology of ischaemic stroke: an integrated view Ulrich Dirnagl, Costantino Iadecola, Michael A. Moskowitz · Trends in Neurosciences Review Sep 1999 3,943
8 The neuropathological diagnosis of Alzheimer’s disease Michael A. Deture, Dennis W. Dickson · Molecular Neurodegeneration Open access 2 Aug 2019 3,455
9 Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry Heiko Braak, Irina I. Alafuzoff, Thomas Arzberger et al. · Acta Neuropathologica Open access 11 Aug 2006 3,344
10 DAMPs, PAMPs and alarmins: all we need to know about danger Marco Emilio Bianchi · Journal of Leukocyte Biology 10 Oct 2006 2,790
11 Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease Paulina V. Arriagada, John H. Growdon, E. Tessa Hedley‐Whyte et al. · Neurology Mar 1992 2,723
12 High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal Michael T. Lotze, Kevin J. Tracey · Nature reviews. Immunology Review Apr 2005 2,533
13 Genomic Analysis of Reactive Astrogliosis Jennifer L. Zamanian, Lijun Xu, Lynette C. Foo et al. · Journal of Neuroscience Open access 2 May 2012 2,525
14 Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis Gerrit Koopman, CP Reutelingsperger, GA Kuijten et al. · Blood Sep 1994 2,466
15 Calmodulin Plays a Pivotal Role in Cellular Regulation Wai Yiu Cheung · Science 4 Jan 1980 2,444
16 Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination Gregory J. Brewer, John R. Torricelli, E. K. Evege et al. · Journal of Neuroscience Research Aug 1993 2,342
17 Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites Filip K. Świrski, Matthias Nahrendorf, Martin Etzrodt et al. · Science Open access 30 Jul 2009 2,228
18 Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials Kennedy R. Lees, Erich Bluhmki, Rüdiger von Kummer et al. · The Lancet May 2010 2,209
19 Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects Leslie M. Shaw, Hugo Vanderstichele, Malgorzata Elzbieta Knapik-Czajka et al. · Annals of Neurology Open access 19 Mar 2009 2,124
20 Calbindin D-28k and parvalbumin in the rat nervous system Marco R. Celio · Neuroscience 1990 2,093
21 Annexins: From Structure to Function Volker Gerke, Stephen E. Moss · Physiological Reviews Review Apr 2002 2,056
22 Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. Marco Baggiolini, Andrew J. Walz, Steven L. Kunkel · Journal of Clinical Investigation Open access Oct 1989 2,002
23 Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates Christa Heussen, Eugene B. Dowdle · Analytical Biochemistry Feb 1980 1,987
24 Fibronectin at a glance Roumen G. Pankov, Kenneth M. Yamada · Journal of Cell Science 15 Oct 2002 1,972
25 Intracellular amyloid-β in Alzheimer's disease Frank M. LaFerla, Kim N. Green, Salvatore Oddo · Nature reviews. Neuroscience Review 6 Jun 2007 1,959
26 Negative Fluid-Attenuated Inversion Recovery- Based Intravenous Thrombolysis Using Recombinant Tissue Plasminogen Activator in Acute Stroke Patients with Unknown Onset Time Junya Aoki, Kazumi Kimura, Kensaku Shibazaki et al. · Cerebrovascular Diseases Extra Open access 23 Mar 2013 1,934
27 RAGE Mediates a Novel Proinflammatory Axis Marion A. Hofmann, Steven Drury, Caifeng Fu et al. · Cell Open access Jun 1999 1,871
28 Definition and Evaluation of Transient Ischemic Attack J. Donald Easton, Jeffrey L. Saver, Gregory W. Albers et al. · Stroke 7 May 2009 1,854
29 Neuroinflammation in Alzheimer's disease: Current evidence and future directions Valeria Calsolaro, Paul Edison · Alzheimer s & Dementia 11 May 2016 1,797
30 Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. W. Sue T. Griffin, Laura C. Stanley, C Ling et al. · Proceedings of the National Academy of Sciences Open access Oct 1989 1,790
31 Neuroinflammation and M2 microglia: the good, the bad, and the inflamed Jonathan D. Cherry, John A. Olschowka, M. Kerry O’Banion · Journal of Neuroinflammation Open access 2 Jun 2014 1,776
32 Pathophysiology of traumatic brain injury Christian D. Werner, Kristin Engelhard · British Journal of Anaesthesia Open access 19 Jun 2007 1,733
33 A soluble protein characteristic of the nervous system Blake W. Moore · Biochemical and Biophysical Research Communications Jun 1965 1,698
34 Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans Constantin Felix Urban, David Ermert, Monika Schmid et al. · PLoS Pathogens Open access 29 Oct 2009 1,697
35 Cognition and anatomy in three variants of primary progressive aphasia Maria Luisa Gorno‐Tempini, Nina F. Dronkers, Katherine P. Rankin et al. · Annals of Neurology Open access 3 Feb 2004 1,649
36 S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles Rosario Donato · The International Journal of Biochemistry & Cell Biology Jul 2001 1,590
37 The Canadian CT Head Rule for patients with minor head injury Ian Gilmour Stiell, George A. Wells, Katherine L. Vandemheen et al. · The Lancet May 2001 1,539
38 S100A8/A9 in Inflammation Siwen Wang, Rui Song, Ziyi Wang et al. · Frontiers in Immunology Open access 11 Jun 2018 1,520
39 Microglial and macrophage polarization—new prospects for brain repair Xiaoming Hu, Rehana Khan Leak, Yejie Shi et al. · Nature Reviews Neurology ReviewOpen access 11 Nov 2014 1,520
40 Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1. C A Dinarello, Joseph G. Cannon, STEWART M. WOLFF et al. · The Journal of Experimental Medicine Open access Jun 1986 1,481
41 Differentiated Rat Glial Cell Strain in Tissue Culture Philippe Benda, J. Lightbody, GORDON H. SATO et al. · Science 26 Jul 1968 1,481
42 Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging Robert D. Bell, Ethan A. Winkler, Abhay P. Sagare et al. · Neuron Open access Nov 2010 1,475
43 Reactive Gliosis and the Multicellular Response to CNS Damage and Disease Joshua E. Burda, Michael V. Sofroniew · Neuron Open access 2014 1,472
44 Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence A. Bignami, Lawrence F. Eng, D. R. Dahl et al. · Brain Research Aug 1972 1,456
45 Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock Thomas Vogl, Klaus Tenbrock, Stephan Ludwig et al. · Nature Medicine Sep 2007 1,441
46 HMGB1 and RAGE in Inflammation and Cancer Gary P. Sims, Daniel C. Rowe, Svend T. Rietdijk et al. · Annual Review of Immunology Review Mar 2010 1,440
47 Focal Cerebral Ischaemia in the Rat: 1. Description of Technique and Early Neuropathological Consequences following Middle Cerebral Artery Occlusion Akira Tamura, David I. Graham, James McCulloch et al. · Journal of Cerebral Blood Flow & Metabolism Mar 1981 1,439
48 The retina as a window to the brain—from eye research to CNS disorders Anat London, Inbal Benhar, Michal Schwartz · Nature Reviews Neurology Review 20 Nov 2012 1,434
49 Annexins: linking Ca2+ signalling to membrane dynamics Volker Gerke, Carl E. Creutz, Stephen E. Moss · Nature Reviews Molecular Cell Biology Review Jun 2005 1,433
50 A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. Shin Yonehara, A Ishii, M Yonehara · The Journal of Experimental Medicine Open access May 1989 1,419

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.