Topic · Signaling Pathways in Disease
Most cited papers in Signaling Pathways in Disease
What are the most cited papers in Signaling Pathways in Disease?
The most cited paper in Signaling Pathways in Disease is "Calcium's Role in Mechanotransduction during Muscle Development" (Tatiana Benavides Damm, Marcel Egli, 2014), with 14,545 citations. Next come "Integrins" (8,635) and "Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor" (6,632).
Showing 50 of 100 papers. Every paper with more than 1,285 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Calcium's Role in Mechanotransduction during Muscle Development Tatiana Benavides Damm, Marcel Egli · Cellular Physiology and Biochemistry | 2014 | 14,545 |
| 2 | Integrins Richard O. Hynes · Cell | Sep 2002 | 8,635 |
| 3 | Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor Anne Sophie Brunet, Azad Bonni, Michael J. Zigmond et al. · Cell | Mar 1999 | 6,632 |
| 4 | Inositol trisphosphate and calcium signalling Michael John Berridge · Nature | 1993 | 6,606 |
| 5 | New functions for the matrix metalloproteinases in cancer progression Mikala Egeblad, Zena Werb · Nature reviews. Cancer | Mar 2002 | 6,127 |
| 6 | The versatility and universality of calcium signalling Michael John Berridge, Peter Lipp, Martin D. Bootman · Nature Reviews Molecular Cell Biology | Oct 2000 | 5,749 |
| 7 | Cell Migration: Integrating Signals from Front to Back Anne J. Ridley, Martin Alexander Schwartz, Keith Burridge et al. · Science | 4 Dec 2003 | 5,046 |
| 8 | The BCL-2 protein family: opposing activities that mediate cell death Richard J. Youle, Andreas Strasser · Nature Reviews Molecular Cell Biology | 21 Dec 2007 | 4,708 |
| 9 | Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases Robert Visse, Hideaki Nagase · Circulation Research | May 2003 | 4,573 |
| 10 | Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes Jun S. Liu, Jesse D. Farmer, Willam S. Lane et al. · Cell | Aug 1991 | 4,175 |
| 11 | Integrin Signaling Filippo G. Giancotti, Erkki I. Ruoslahti · Science | 13 Aug 1999 | 3,870 |
| 12 | Activators and target genes of Rel/NF-κB transcription factors Heike Luise Pahl · Oncogene | 22 Nov 1999 | 3,715 |
| 13 | Structure and function of matrix metalloproteinases and TIMPs Hiroyuki Nagase, Robert Visse, G MURPHY · Cardiovascular Research | 6 Jan 2006 | 3,436 |
| 14 | A protein kinase involved in the regulation of inflammatory cytokine biosynthesis John C. Lee, Jeffrey T. Laydon, Peter McDonnell et al. · Nature | Dec 1994 | 3,317 |
| 15 | AP-1 function and regulation Michael Karin, Zheng-gang Liu, Ebrahim Zandi · Current Opinion in Cell Biology | Apr 1997 | 2,941 |
| 16 | Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations Lisa M. Coussens, Barbara Fingleton, Lynn McCormick Matrisian · Science | 29 Mar 2002 | 2,775 |
| 17 | Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4 Paul D. Waterhouse, Josef Martin Penninger, Emma M. Timms et al. · Science | 10 Nov 1995 | 2,772 |
| 18 | Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo Sue C. Bodine, Trevor N. Stitt, Michael Gonzalez et al. · Nature Cell Biology | 10 Oct 2001 | 2,769 |
| 19 | Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts Hiroshi Takayanagi, Sunhwa Kim, Takako Koga et al. · Developmental Cell | Dec 2002 | 2,708 |
| 20 | TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function Anjana Rao, Chun Huai Luo, Patrick G. Hogan · Annual Review of Immunology | Apr 1997 | 2,631 |
| 21 | A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy Jeffery D. Molkentin, Jianrong Lu, Christopher L. Antos et al. · Cell | Apr 1998 | 2,595 |
| 22 | The mitochondrial permeability transition pore and its role in cell death Martin Crompton · Biochemical Journal | 8 Jul 1999 | 2,338 |
| 23 | The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions Matthias Nahrendorf, Filip K. Świrski, Elena Aïkawa et al. · The Journal of Experimental Medicine | 19 Nov 2007 | 2,316 |
| 24 | AP-1: a double-edged sword in tumorigenesis Robert Eferl, Erwin Friedrich Wagner · Nature reviews. Cancer | Nov 2003 | 2,289 |
| 25 | Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death Christopher P. Baines, Robert A. Kaiser, Nicole H. Purcell et al. · Nature | Mar 2005 | 2,276 |
| 26 | The Biological Basis for Cardiac Repair After Myocardial Infarction Sumanth D. Prabhu, Nikolaos G. Frangogiannis · Circulation Research | 24 Jun 2016 | 2,275 |
| 27 | Neurotrophin-regulated signalling pathways Louis French Reichardt · Philosophical Transactions of the Royal Society B Biological Sciences | Aug 2006 | 2,213 |
| 28 | The mechanism of action of cyclosporin A and FK506 Stuart L. Schreiber, Gerald R Crabtree · Immunology Today | 1992 | 2,153 |
| 29 | Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products Susan Amara, Vivian Jonas, Michael G. Rosenfeld et al. · Nature | Jul 1982 | 2,138 |
| 30 | Signal transduction by lymphocyte antigen receptors Arthur Weiss, Dan R. Littman · Cell | 1994 | 2,120 |
| 31 | A mammalian protein targeted by G1-arresting rapamycin–receptor complex Eric J. Brown, Mark W. Albers, Tae Bum Shin et al. · Nature | Jun 1994 | 2,082 |
| 32 | Calcium - a life and death signal Michael John Berridge, Martin D. Bootman, Peter Lipp · Nature | Oct 1998 | 2,079 |
| 33 | Neurotrophin regulation of neural circuit development and function Hyungju Park, Mu‐ming Poo · Nature reviews. Neuroscience | 20 Dec 2012 | 2,071 |
| 34 | The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity Chen Ying Zhu, Ana Carrizosa Anderson, Anna Schubart et al. · Nature Immunology | 13 Nov 2005 | 2,069 |
| 35 | Discovering High-Affinity Ligands for Proteins: SAR by NMR Suzanne Beckham Shuker, Philip J. Hajduk, Robert P. Meadows et al. · Science | 29 Nov 1996 | 2,061 |
| 36 | Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast Joseph Heitman, N. Rao Movva, Michael N. Hall · Science | 23 Aug 1991 | 2,057 |
| 37 | Transcriptional regulation by calcium, calcineurin, and NFAT Patrick G. Hogan, Lin Chen, Julie Nardone et al. · Genes & Development | 15 Sep 2003 | 2,019 |
| 38 | The inflammatory response in myocardial infarction Nikolaos G. Frangogiannis · Cardiovascular Research | 2002 | 2,010 |
| 39 | PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor) Steven O. Marx, Steven R. Reiken, Yuji Hisamatsu et al. · Cell | May 2000 | 1,988 |
| 40 | X-linked IAP is a direct inhibitor of cell-death proteases Quinn L. Deveraux, Ryōsuke Takahashi, Guy S. Salvesen et al. · Nature | 17 Jul 1997 | 1,966 |
| 41 | Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury Won Kon Han, Véronique Bailly, Rekha Abichandani et al. · Kidney International | Jul 2002 | 1,954 |
| 42 | Matrix metalloproteinases as modulators of inflammation and innate immunity William C. Parks, Carole L. Wilson, Yolanda S. López-Boado · Nature reviews. Immunology | 30 Jul 2004 | 1,934 |
| 43 | Calcium oscillations increase the efficiency and specificity of gene expression Ricardo E. Dolmetsch, Keli Xu, Richard S. Lewis · Nature | Apr 1998 | 1,907 |
| 44 | Regulation of cardiac hypertrophy by intracellular signalling pathways Joerg Heineke, Jeffery D. Molkentin · Nature Reviews Molecular Cell Biology | Aug 2006 | 1,885 |
| 45 | ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs Jin Ye, Robert B. Rawson, Ryutaro Komuro et al. · Molecular Cell | Dec 2000 | 1,883 |
| 46 | The GDNF family: Signalling, biological functions and therapeutic value Matti S. Airaksinen, Märt Saarma · Nature reviews. Neuroscience | May 2002 | 1,860 |
| 47 | A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p JACK E. TAUNTON, Christian A. Hassig, Stuart L. Schreiber · Science | 19 Apr 1996 | 1,826 |
| 48 | The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases Griselda A. Cabral-Pacheco, Idalia Garza Veloz, Claudia Castruita-De la Rosa et al. · International Journal of Molecular Sciences | 20 Dec 2020 | 1,809 |
| 49 | Role of integrins in cell invasion and migration John D. Hood, David A. Cheresh · Nature reviews. Cancer | Feb 2002 | 1,789 |
| 50 | The inflammatory response in myocardial injury, repair, and remodelling Nikolaos G. Frangogiannis · Nature Reviews Cardiology | 25 Mar 2014 | 1,752 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.