Most cited papers in Sphingolipid Metabolism and Signaling
What are the most cited papers in Sphingolipid Metabolism and Signaling?
The most cited paper in Sphingolipid Metabolism and Signaling is "Membrane lipids: where they are and how they behave" (Gerrit van Meer, Dennis R. Voelker, Gerald W. Feigenson, 2008), with 7,319 citations. Next come "Lipid rafts and signal transduction" (6,284) and "Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains" (3,933).
Showing 50 of 100 papers. Every paper with more than 834 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Membrane lipids: where they are and how they behave Gerrit van Meer, Dennis R. Voelker, Gerald W. Feigenson · Nature Reviews Molecular Cell Biology | 23 Jan 2008 | 7,319 |
| 2 | Lipid rafts and signal transduction Kai Simons, Derek K. Toomre · Nature Reviews Molecular Cell Biology | Oct 2000 | 6,284 |
| 3 | Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains Markus Ritter, Sabine Schmidt, Martin Jakab et al. · Cellular Physiology and Biochemistry | 2013 | 3,933 |
| 4 | Principles of bioactive lipid signalling: lessons from sphingolipids Yusuf Awni Hannun, Lina Marie Obeid · Nature Reviews Molecular Cell Biology | 23 Jan 2008 | 3,378 |
| 5 | FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES Deborah A. Brown, Erwin London · Annual Review of Cell and Developmental Biology | Nov 1998 | 2,963 |
| 6 | A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis Ludwig Kappos, Ernst‐Wilhelm Radue, Paul O’Connor et al. · New England Journal of Medicine | 20 Jan 2010 | 2,658 |
| 7 | Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 Mehrdad Matloubian, Charles G. Lo, Guy Cinamon et al. · Nature | 2004 | 2,592 |
| 8 | Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study Lutz Nährlich, Jochen Georg Mainz, Constantin Adams et al. · Cellular Physiology and Biochemistry | 2013 | 2,535 |
| 9 | IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel Vanda A. Lennon, Thomas J. Kryzer, Sean Joseph Pittock et al. · The Journal of Experimental Medicine | 8 Aug 2005 | 2,299 |
| 10 | Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis Jeffrey A. Cohen, Frederik Barkhof, Gıancarlo Comı et al. · New England Journal of Medicine | 20 Jan 2010 | 2,217 |
| 11 | The mystery of membrane organization: composition, regulation and roles of lipid rafts Erdinç Sezgin, Ilya Levental, Satyajit Mayor et al. · Nature Reviews Molecular Cell Biology | 30 Mar 2017 | 2,210 |
| 12 | Understanding the diversity of membrane lipid composition T. HARAYAMA, Howard Riezman · Nature Reviews Molecular Cell Biology | 7 Feb 2018 | 2,144 |
| 13 | Sphingolipids and their metabolism in physiology and disease Yusuf Awni Hannun, Lina Marie Obeid · Nature Reviews Molecular Cell Biology | 22 Nov 2017 | 2,126 |
| 14 | Sphingosine-1-phosphate: an enigmatic signalling lipid Sarah Spiegel, Sheldon Milstien · Nature Reviews Molecular Cell Biology | May 2003 | 2,091 |
| 15 | Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells Nobuyoshi Kosaka, Haruhisa Iguchi, Yusuke Yoshioka et al. · Journal of Biological Chemistry | 30 Mar 2010 | 1,977 |
| 16 | Programmed Cell Death Induced by Ceramide Lina Marie Obeid, Corinne Mary Linardic, Linda A. Karolak et al. · Science | 19 Mar 1993 | 1,813 |
| 17 | Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis Marcel Verheij, Ron Bose, Xin Lin et al. · Nature | Mar 1996 | 1,799 |
| 18 | Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists SUZANNE M. MANDALA, Richard Hajdu, James D. Bergstrom et al. · Science | 12 Apr 2002 | 1,698 |
| 19 | Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation Emmanuel Le Poul, Cécile Loison, Sofie Struyf et al. · Journal of Biological Chemistry | Jul 2003 | 1,662 |
| 20 | Functions of Ceramide in Coordinating Cellular Responses to Stress Yusuf Awni Hannun · Science | 13 Dec 1996 | 1,631 |
| 21 | Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation Vicky Lampropoulou, Alexey Sergushichev, Monika Bambousková et al. · Cell Metabolism | Jul 2016 | 1,572 |
| 22 | Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate Olivier Cuvillier, Grisha Pirianov, Burkhard Kleuser et al. · Nature | Jun 1996 | 1,551 |
| 23 | Separation of Liquid Phases in Giant Vesicles of Ternary Mixtures of Phospholipids and Cholesterol Sarah L. Veatch, Sarah L. Keller · Biophysical Journal | Nov 2003 | 1,529 |
| 24 | The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors Volker Brinkmann, Michael D. Davis, Christopher E. Heise et al. · Journal of Biological Chemistry | Jun 2002 | 1,519 |
| 25 | Rafts defined: a report on the Keystone symposium on lipid rafts and cell function LINDA JOY PIKE · Journal of Lipid Research | 27 Apr 2006 | 1,494 |
| 26 | Lipid mediator class switching during acute inflammation: signals in resolution Bruce David Levy, Clary B. Clish, Birgitta A. R. Schmidt et al. · Nature Immunology | Jul 2001 | 1,455 |
| 27 | Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow Yoshio Katayama, Michela Battista, Wei-Ming Kao et al. · Cell | 2006 | 1,388 |
| 28 | Lipid Rafts Reconstituted in Model Membranes Christian Dietrich, Luís A. Bagatolli, Zoya Volovyk et al. · Biophysical Journal | Mar 2001 | 1,377 |
| 29 | Lipidomics reveals a remarkable diversity of lipids in human plasma Oswald Quehenberger et al. · Journal of Lipid Research | 29 Jul 2010 | 1,368 |
| 30 | Mechanisms of Antibacterial Action of Three Monoterpenes Domenico Trombetta, Francesco Castelli, Maria Grazia Sarpietro et al. · Antimicrobial Agents and Chemotherapy | 25 May 2005 | 1,357 |
| 31 | The State of Lipid Rafts: From Model Membranes to Cells Michael A. Edidin · Annual Review of Biophysics and Biomolecular Structure | Jun 2003 | 1,349 |
| 32 | A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood Michael Scott Brown, Joseph L. Goldstein · Proceedings of the National Academy of Sciences | 28 Sep 1999 | 1,340 |
| 33 | Pathophysiologic Implications of Membrane Phospholipid Asymmetry in Blood Cells Robert F. A. Zwaal, Alan Jay Schroit · Blood | 15 Feb 1997 | 1,337 |
| 34 | Sphingolipid metabolites in inflammatory disease Michael W. Maceyka, Sarah Spiegel · Nature | 3 Jun 2014 | 1,316 |
| 35 | Acidic extracellular microenvironment and cancer Yukio Kato, Shigeyuki Ozawa, Chihiro Miyamoto et al. · Cancer Cell International | 2013 | 1,308 |
| 36 | Lipid signalling in disease Matthias P. Wymann, Roger Schneiter · Nature Reviews Molecular Cell Biology | 23 Jan 2008 | 1,304 |
| 37 | How Cells Handle Cholesterol Kai Simons, Elina Ikonen · Science | Dec 2000 | 1,283 |
| 38 | Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis Volker Brinkmann, Andreas Billich, Thomas Baumruker et al. · Nature Reviews Drug Discovery | 29 Oct 2010 | 1,277 |
| 39 | Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation Yusuf Awni Hannun, Robert M. Bell · Science | 27 Jan 1989 | 1,258 |
| 40 | Sphingolipid metabolism in cancer signalling and therapy Besim Öğretmen · Nature reviews. Cancer | 17 Nov 2017 | 1,254 |
| 41 | The sphingomyelin cycle and the second messenger function of ceramide. Yusuf Awni Hannun · Journal of Biological Chemistry | Feb 1994 | 1,252 |
| 42 | Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages Stanley Ching‐Cheng Huang, Bart Everts, Yulia Ivanova et al. · Nature Immunology | 3 Aug 2014 | 1,250 |
| 43 | Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance William L. Holland, Joseph T. Brozinick, Liping Wang et al. · Cell Metabolism | Mar 2007 | 1,231 |
| 44 | Revitalizing membrane rafts: new tools and insights Kai Simons, Mathias J. Gerl · Nature Reviews Molecular Cell Biology | 23 Sep 2010 | 1,228 |
| 45 | Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb Andrew R. Tee, Brendan D. Manning, Philippe P. Roux et al. · Current Biology | Aug 2003 | 1,225 |
| 46 | Biologically active sphingolipids in cancer pathogenesis and treatment Besim Öğretmen, Yusuf Awni Hannun · Nature reviews. Cancer | 30 Jul 2004 | 1,221 |
| 47 | GPI-anchored proteins are organized in submicron domains at the cell surface Rajat Varma, Satyajit Mayor · Nature | Aug 1998 | 1,215 |
| 48 | Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators). Constantinos Alexandros Demopoulos, R. Neal Pinckard, D J Hanahan · Journal of Biological Chemistry | Oct 1979 | 1,207 |
| 49 | CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs Lawrence R. Shiow, David Brian Rosen, Naděžda Brdičková et al. · Nature | Mar 2006 | 1,193 |
| 50 | Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease Roy G. Cutler, Jeremiah Kelly, Kristin Storie et al. · Proceedings of the National Academy of Sciences | 15 Feb 2004 | 1,161 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.