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Topic · Molecular Biology

Sphingolipid Metabolism and Signaling

Sphingolipid Metabolism and Signaling is a research topic within Molecular Biology. Science Explorer counts 15k research works in it since 1953. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the role of sphingolipids, including sphingosine-1-phosphate and ceramide, in signaling and metabolism, with implications for health and disease such as lymphocyte egress, insulin resistance, cancer, and apoptosis.

  • Sphingolipids
  • Sphingosine-1-Phosphate
  • Ceramide
  • Lysophospholipids
  • Sphingosine Kinase
  • FTY720
  • Lymphocyte Egress
  • Insulin Resistance
  • Cancer
  • Apoptosis
Research works
15k
fractional, since 1953
In the world top 10%
1.5k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+1%
the tick is no change
Largest producer
China
39% of the 10 largest, 2022-now
Sphingolipid Metabolism and Signaling

Which countries lead Sphingolipid Metabolism and Signaling research?

By volume, China and the United States publish the most (798 and 525 works in 2022-now).

By volume, 2022-now

  1. 1 China 798 works
  2. 2 United States 525 works
  3. 3 Japan 167 works
  4. 4 Germany 133 works
  5. 5 Italy 87 works
  6. 6 India 86 works
  7. 7 South Korea 78 works
  8. 8 France 66 works
  9. 9 United Kingdom 61 works
  10. 10 Spain 56 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 38.8%United States: 25.5%Japan: 8.1%Germany: 6.5%6 others listed: 21.0%39%largest
China798 · 38.8%United States525 · 25.5%Japan167 · 8.1%Germany133 · 6.5%6 others listed433 · 21.0%

Shares of the rows listed above, not of the whole node.

Which institutions lead Sphingolipid Metabolism and Signaling research?

By volume in 2022-now, Shanghai Jiao Tong University publishes the most Sphingolipid Metabolism and Signaling research, followed by Harvard University and Virginia Commonwealth University.

By volume, 2022-now

  1. 1 Shanghai Jiao Tong UniversityChina 21 works
  2. 2 Harvard UniversityUnited States 18 works
  3. 3 Virginia Commonwealth UniversityUnited States 16 works
  4. 4 Chinese Academy of SciencesChina 16 works
  5. 5 Capital Medical UniversityChina 15 works
  6. 6 Centre National de la Recherche ScientifiqueFrance 15 works
  7. 7 Sun Yat-sen UniversityChina 15 works
  8. 8 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 14 works
  9. 9 Peking UniversityChina 14 works
  10. 10 Sichuan UniversityChina 14 works

Who are the leading researchers in Sphingolipid Metabolism and Signaling?

The most-cited researchers publishing on Sphingolipid Metabolism and Signaling include Shizuo Akira, Luigi Ferrucci and Frank B. Hu.

  1. 1 Shizuo Akira Japan 342k citations
  2. 2 Luigi Ferrucci United States 281k citations
  3. 3 Frank B. Hu United States 281k citations
  4. 4 Hagop M. Kantarjian United States 273k citations
  5. 5 Gordon Brent Mills United States 265k citations
  6. 6 Charles M. Perou United States 263k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Sphingolipid Metabolism and Signaling?

The most cited paper in Sphingolipid Metabolism and Signaling is "Membrane lipids: where they are and how they behave" (Gerrit van Meer, Dennis R. Voelker, Gerald W. Feigenson, 2008), with 7,319 citations. Next come "Lipid rafts and signal transduction" (6,284) and "Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains" (3,933).

Most cited papers
#PaperReleasedCitations
1 Membrane lipids: where they are and how they behave Gerrit van Meer, Dennis R. Voelker, Gerald W. Feigenson · Nature Reviews Molecular Cell Biology ReviewOpen access 23 Jan 2008 7,319
2 Lipid rafts and signal transduction Kai Simons, Derek K. Toomre · Nature Reviews Molecular Cell Biology Review Oct 2000 6,284
3 Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains Markus Ritter, Sabine Schmidt, Martin Jakab et al. · Cellular Physiology and Biochemistry Open access 2013 3,933
4 Principles of bioactive lipid signalling: lessons from sphingolipids Yusuf Awni Hannun, Lina Marie Obeid · Nature Reviews Molecular Cell Biology Review 23 Jan 2008 3,378
5 FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES Deborah A. Brown, Erwin London · Annual Review of Cell and Developmental Biology Review Nov 1998 2,963
All 100 most cited papers, with filters and sorting

Where is Sphingolipid Metabolism and Signaling research done?

The largest centres of Sphingolipid Metabolism and Signaling research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Tokyo (Japan).

Largest cities, 2022-now

  1. 1 BeijingChina 99 works
  2. 2 ShanghaiChina 66 works
  3. 3 GuangzhouChina 58 works
  4. 4 TokyoJapan 46 works
  5. 5 NanjingChina 41 works
  6. 6 WuhanChina 31 works
  7. 7 SeoulSouth Korea 30 works
  8. 8 HangzhouChina 29 works
  9. 9 New YorkUnited States 28 works
  10. 10 ParisFrance 28 works
See Sphingolipid Metabolism and Signaling on the map

Where is the best place to study Sphingolipid Metabolism and Signaling?

Among universities, judged by research, Shanghai Jiao Tong University, Harvard University and Nanjing University of Chinese Medicine score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 16.52%fractional works in this field (log) →share of work in the world top 10% →Shanghai Jiao Tong U…Sun Yat-sen UniversityHarvard UniversityNanjing University o…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Shanghai Jiao Tong UniversityChina 76.617.4%3.2×21 +36.1%
2Harvard UniversityUnited States 76.315.8%2.5×18 +5.4%
3Nanjing University of Chinese MedicineChina 62.415.4%19.4×11 +127.2%
4Sun Yat-sen UniversityChina 60.217.4%3.2×15 -5.1%
5Cornell UniversityUnited States 60.212.5%3.4×10 +4.5%
6Virginia Commonwealth UniversityUnited States 57.89.9%20.6×16 -34.7%
7University of UtahUnited States 57.716.4%5.5×8 +61.5%
8Huazhong University of Science and TechnologyChina 57.519.9%2.6×10 +27.0%
9Sichuan UniversityChina 57.116.7%2.7×14 +9.1%
10Wuhan UniversityChina 57.123.8%2.7×8 +56.2%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Sphingolipid Metabolism and Signaling, country by country

Is Sphingolipid Metabolism and Signaling research growing?

Output in 2022-2025 was 1% higher than in 2018-2021, peaking in 2020. The fastest-growing topics are Sphingolipid Metabolism and Signaling.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Sphingolipid Metabolism and Signaling as a percentage of every work published that year, 0.0098% in 2024.

still counting0.010%0.020%0.030%Sphingolipid Metabolism and Signaling0.0097% in 202519801990200020102020

Fractional works of Sphingolipid Metabolism and Signaling over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Sphingolipid Metabolism and Signaling10.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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