Most cited papers in Synthesis and Biological Evaluation
What are the most cited papers in Synthesis and Biological Evaluation?
The most cited paper in Synthesis and Biological Evaluation is "Fluorine in medicinal chemistry" (Sophie Purser, Peter R. Moore, Steve Swallow et al., 2007), with 7,580 citations. Next come "Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals" (6,486) and "Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)" (4,838).
Showing 50 of 100 papers. Every paper with more than 637 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Fluorine in medicinal chemistry Sophie Purser, Peter R. Moore, Steve Swallow et al. · Chemical Society Reviews | 13 Dec 2007 | 7,580 |
| 2 | Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals Edon Vitaku, David T. Smith, Jón T. Njardarson · Journal of Medicinal Chemistry | 25 Sep 2014 | 6,486 |
| 3 | Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011) Jiang Wang, María Sánchez‐Roselló, José Luis Aceña et al. · Chemical Reviews | 3 Dec 2013 | 4,838 |
| 4 | The Many Roles for Fluorine in Medicinal Chemistry William K. Hagmann · Journal of Medicinal Chemistry | 21 Jun 2008 | 3,617 |
| 5 | Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas Yu Chang Zhou, Jiang Wang, Zhanni Gu et al. · Chemical Reviews | 12 Jan 2016 | 2,807 |
| 6 | FLUORESCENCE OF CATECHOL AMINES AND RELATED COMPOUNDS CONDENSED WITH FORMALDEHYDE BENGT FALCK, N.‐Å. Hillarp, Georg Thieme et al. · Journal of Histochemistry & Cytochemistry | May 1962 | 2,708 |
| 7 | Organic Azides: An Exploding Diversity of a Unique Class of Compounds Stefan Bräse, Carmen Gil, Kerstin Knepper et al. · Angewandte Chemie International Edition | 15 Aug 2005 | 2,226 |
| 8 | Novel Procedure for Modeling Ligand/Receptor Induced Fit Effects Woody Sherman, Tyler Day, Matthew P. Jacobson et al. · Journal of Medicinal Chemistry | 23 Dec 2005 | 2,083 |
| 9 | Radioimmunoassay for Cyclic Nucleotides Alton L. Steiner, Charles W. Parker, DAVID M. KIPNIS · Journal of Biological Chemistry | Feb 1972 | 2,032 |
| 10 | Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. Carl Nathan, Henry W. Murray, Michael E. Wiebe et al. · The Journal of Experimental Medicine | Sep 1983 | 1,973 |
| 11 | Contribution of Organofluorine Compounds to Pharmaceuticals Munenori Inoue, Yuji Sumii, Norio Shibata · ACS Omega | 22 Apr 2020 | 1,948 |
| 12 | Activating Receptors and Coreceptors Involved in Human Natural Killer Cell-Mediated Cytolysis Alessandro Moretta, Cristina Bottino, Massimo Vitale et al. · Annual Review of Immunology | Apr 2001 | 1,785 |
| 13 | Analyzing Reaction Rates with the Distortion/Interaction‐Activation Strain Model F. Matthias Bickelhaupt, Kendall N. Houk · Angewandte Chemie International Edition | 26 Apr 2017 | 1,744 |
| 14 | A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications Nagaraju Kerru, Lalitha Gummidi, Suresh Maddila et al. · Molecules | 20 Apr 2020 | 1,719 |
| 15 | NRF2 and the Hallmarks of Cancer Montserrat Rojo de la Vega, Eli Chapman, Donna D. Zhang · Cancer Cell | 3 May 2018 | 1,707 |
| 16 | A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Yuesheng Zhang, Paul Talalay, C G Cho et al. · Proceedings of the National Academy of Sciences | 15 Mar 1992 | 1,689 |
| 17 | Organometallic Anticancer Compounds Gilles Gasser, Ingo Ott, Nils Metzler‐Nolte · Journal of Medicinal Chemistry | 15 Nov 2010 | 1,619 |
| 18 | Metabolism and Disposition Kinetics of Nicotine Janne Hukkanen, Pleyton Jacob, Neal L. Benowitz · Pharmacological Reviews | 24 Feb 2005 | 1,598 |
| 19 | Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity. G. Gross, Tova Waks, Zelig Eshhar · Proceedings of the National Academy of Sciences | Dec 1989 | 1,588 |
| 20 | Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II K M Tewey, Thomas C. Rowe, Liu Yang et al. · Science | 26 Oct 1984 | 1,551 |
| 21 | METHOD FOR THE DETERMINATION OF HEXOSAMINES IN TISSUES Norman F. Boas · Journal of Biological Chemistry | Oct 1953 | 1,533 |
| 22 | Fluorine substituent effects (on bioactivity) Bruce E. Smart · Journal of Fluorine Chemistry | Jun 2001 | 1,488 |
| 23 | Chemistry in living systems Jennifer A. Prescher, Carolyn Ruth Bertozzi · Nature Chemical Biology | 25 May 2005 | 1,468 |
| 24 | Chalcone: A Privileged Structure in Medicinal Chemistry Chunlin Zhuang, Wen Zhang, Chunquan Sheng et al. · Chemical Reviews | 10 May 2017 | 1,465 |
| 25 | Adenosine receptors as therapeutic targets Kenneth A. Jacobson, Zhan‐Guo Gao · Nature Reviews Drug Discovery | Mar 2006 | 1,430 |
| 26 | Clinical, Cellular, and Molecular Factors That Contribute to Antifungal Drug Resistance Theodore C. White, Kieren A. Marr, Raleigh Anne Bowden · Clinical Microbiology Reviews | Apr 1998 | 1,361 |
| 27 | Drug–DNA interactions and their study by UV–Visible, fluorescence spectroscopies and cyclic voltametry Muhammad Sirajuddin, Saqib Ali, Amin Badshah · Journal of Photochemistry and Photobiology B Biology | 6 Apr 2013 | 1,335 |
| 28 | Chagas disease José Antonio Pérez-Molina, Israel Molina · The Lancet | 30 Jun 2017 | 1,314 |
| 29 | Synthesis of Heterocycles via Palladium-Catalyzed Carbonylations Xiao‐Feng Wu, Helfried Neumann, Matthias Beller · Chemical Reviews | 5 Oct 2012 | 1,285 |
| 30 | FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics. Toru Kino, Hiroshi Hatanaka, MICHISANE HASHIMOTO et al. · The Journal of Antibiotics | 1987 | 1,255 |
| 31 | 100 years of the biginelli dihydropyrimidine synthesis Christian Oliver Kappe · Tetrahedron | Aug 1993 | 1,226 |
| 32 | Prescribed drugs containing nitrogen heterocycles: an overview Majid M. Heravi, Vahideh Zadsirjan · RSC Advances | 2020 | 1,190 |
| 33 | Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. Annalisa D’Andrea, Manthrasalam Rengaraju, Nicholas M. Valiante et al. · The Journal of Experimental Medicine | Nov 1992 | 1,163 |
| 34 | From 2000 to Mid-2010: A Fruitful Decade for the Synthesis of Pyrazoles Santos Fustero, María Sánchez‐Roselló, Pablo Barrio et al. · Chemical Reviews | Aug 2011 | 1,153 |
| 35 | Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments Kenneth L. Kirk · Organic Process Research & Development | 26 Jan 2008 | 1,151 |
| 36 | 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a Neuroprotectant for Cerebral Ischemia Malcolm J. Sheardown, Elsebet Østergaard Nielsen, Anker Jón Hansen et al. · Science | 2 Feb 1990 | 1,144 |
| 37 | Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. John Garthwaite, Eric Southam, Caroline L. Boulton et al. · Molecular Pharmacology | Aug 1995 | 1,104 |
| 38 | Carbon Trifluoromethylation Reactions of Hydrocarbon Derivatives and Heteroarenes Concepción Alonso, Edorta Martínez de Marigorta, Gloria Rubiales et al. · Chemical Reviews | 30 Jan 2015 | 1,079 |
| 39 | MercuryII-Mediated Formation of Thymine−HgII−Thymine Base Pairs in DNA Duplexes Yoko Miyake, Humika Togashi, Mitsuru Tashiro et al. · Journal of the American Chemical Society | Feb 2006 | 1,075 |
| 40 | The global problem of antifungal resistance: prevalence, mechanisms, and management David S. Perlin, Riina Rautemaa‐Richardson, Ana Alastruey‐Izquierdo · The Lancet Infectious Diseases | 31 Jul 2017 | 1,067 |
| 41 | Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase 1 gene Venugopal Radjendirane, Anil K. Jaiswal · Proceedings of the National Academy of Sciences | 10 Dec 1996 | 1,040 |
| 42 | Reactions of oxyl radicals with DNA Anthony P. Breen, John Anthony Murphy · Free Radical Biology and Medicine | Jun 1995 | 1,038 |
| 43 | An Update on the Nitrogen Heterocycle Compositions and Properties of U.S. FDA-Approved Pharmaceuticals (2013–2023) Christopher M. Marshall, John G. Federice, Chloe N. Bell et al. · Journal of Medicinal Chemistry | 12 Jul 2024 | 1,016 |
| 44 | A Critical Review on Chagas Disease Chemotherapy José Rodrigues Coura, Solange Lisboa de Castro · Memórias do Instituto Oswaldo Cruz | 2002 | 1,013 |
| 45 | The Chemistry of Vicinal Diamines Denis Lucet, Thierry Le Gall, Charles Mioskowski · Angewandte Chemie International Edition | 16 Oct 1998 | 1,001 |
| 46 | Simple Coumarins and Analogues in Medicinal Chemistry: Occurrence, Synthesis and Biological Activity Fernanda Borges, Fernanda M.F. Roleira, Nuno Milhazes et al. · Current Medicinal Chemistry | 29 Mar 2005 | 998 |
| 47 | A simple phase-extraction assay for chloramphenicol acyltransferase activity Brian Seed, Jenq-Yunn Sheen · Gene | Jul 1988 | 986 |
| 48 | Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics Neal L. Benowitz · The Annual Review of Pharmacology and Toxicology | 3 Oct 2008 | 978 |
| 49 | Determination of the immunoreactive function of radiolabeled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess Tore Lindmo, Epie Boven, Frank F. Cuttitta et al. · Journal of Immunological Methods | Aug 1984 | 944 |
| 50 | A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX Sabine Couturier, Daniel Bertrand, Jean‐Marc Matter et al. · Neuron | Dec 1990 | 938 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.