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Most cited papers in Synthesis and Catalytic Reactions

What are the most cited papers in Synthesis and Catalytic Reactions?

The most cited paper in Synthesis and Catalytic Reactions is "A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes" (Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al., 2002), with 11,614 citations. Next come "Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions" (6,127) and "CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals" (2,994).

Showing 50 of 100 papers. Every paper with more than 883 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition 15 Jul 2002 11,614
2 Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions Thomas W. Lyons, Melanie Sarah Sanford · Chemical Reviews ReviewOpen access 15 Jan 2010 6,127
3 CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals Junichiro Yamaguchi, Atsushi D. Yamaguchi, Kenichiro Itami · Angewandte Chemie International Edition 6 Aug 2012 2,994
4 Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design Nicholas A. Meanwell · Journal of Medicinal Chemistry Open access 17 Mar 2011 2,856
5 Cross-Dehydrogenative Coupling (CDC): Exploring C−C Bond Formations beyond Functional Group Transformations Chao‐Jun Li · Accounts of Chemical Research 16 Dec 2008 2,780
6 Understanding and exploiting C–H bond activation Jay A. Labinger, John E. Bercaw · Nature May 2002 2,775
7 Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions Keary M. Engle, Tian‐Sheng Mei, Masayuki Wasa et al. · Accounts of Chemical Research Open access 14 Dec 2011 2,726
8 Towards mild metal-catalyzed C–H bond activation Joanna Wencel‐Delord, Thomas Dröge, Fan Liu et al. · Chemical Society Reviews Review 2011 2,459
9 Recent advances in the transition metal-catalyzed twofold oxidative C–H bond activation strategy for C–C and C–N bond formation Seung Hwan Cho, Ji Young Kim, Jaesung Kwak et al. · Chemical Society Reviews ReviewOpen access 2011 2,361
10 Catalytic C–H functionalization by metal carbenoid and nitrenoid insertion Huw M. L. Davies, James R. Manning · Nature Open access 2008 2,325
11 Organic Azides: An Exploding Diversity of a Unique Class of Compounds Stefan Bräse, Carmen Gil, Kerstin Knepper et al. · Angewandte Chemie International Edition 15 Aug 2005 2,226
12 Transition Metal-Catalyzed C–H Amination: Scope, Mechanism, and Applications Yoonsu Park, Youyoung Kim, Sukbok Chang · Chemical Reviews Review 4 Jan 2017 2,177
13 C-H Bond Functionalization in Complex Organic Synthesis Kamil Godula, Dalibor Sameš · Science 6 Apr 2006 2,162
14 Palladium-Catalyzed Transformations of Alkyl C–H Bonds Jian Feng He, Masayuki Wasa, Kelvin S. L. Chan et al. · Chemical Reviews ReviewOpen access 2 Dec 2016 2,065
15 Catalytic Functionalization of C(sp 2 )H and C(sp 3 )H Bonds by Using Bidentate Directing Groups Guy Rouquet, Naoto Chatani · Angewandte Chemie International Edition 17 Sep 2013 2,008
16 Palladium- and Copper-Catalyzed Arylation of Carbon−Hydrogen Bonds Olafs Daugulis, Hien‐Quang Do, Dmitry Shabashov · Accounts of Chemical Research Open access 24 Jun 2009 1,986
17 Metal–Salen Schiff base complexes in catalysis: practical aspects Pier Giorgio Cozzi · Chemical Society Reviews Review 2004 1,974
18 Olefin Metathesis and Beyond Alois Fürstner · Angewandte Chemie International Edition Sep 2000 1,945
19 The Carbon Dioxide Hydration Activity of Carbonic Anhydrase Raja G. Khalifah · Journal of Biological Chemistry Open access Apr 1971 1,915
20 Advances in Synthetic Applications of Hypervalent Iodine Compounds Akira Yoshimura, Viktor V. Zhdankin · Chemical Reviews Review 10 Feb 2016 1,850
21 Chemistry of Polyvalent Iodine Viktor V. Zhdankin, Peter J. Stang · Chemical Reviews ReviewOpen access 6 Nov 2008 1,813
22 Mild metal-catalyzed C–H activation: examples and concepts Tobias Gensch, Matthew N. Hopkinson, Frank Glorius et al. · Chemical Society Reviews ReviewOpen access 2016 1,794
23 Transition Metal-Mediated Cycloaddition Reactions Mark Lautens, Wolfgang Klute, William Tam · Chemical Reviews Review 1996 1,780
24 The medicinal chemist's toolbox for late stage functionalization of drug-like molecules Tim Cernak, Kevin D. Dykstra, Sriram Tyagarajan et al. · Chemical Society Reviews Review 28 Oct 2015 1,780
25 A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications Nagaraju Kerru, Lalitha Gummidi, Suresh Maddila et al. · Molecules Open access 20 Apr 2020 1,719
26 Copper(I)-Catalyzed Synthesis of Azoles. DFT Study Predicts Unprecedented Reactivity and Intermediates Fahmi Himo, Timothy Lovell, Robert Hilgraf et al. · Journal of the American Chemical Society 8 Dec 2004 1,714
27 A comprehensive overview of directing groups applied in metal-catalysed C–H functionalisation chemistry Carlo Sambiagio, David Schönbauer, Rémi Blieck et al. · Chemical Society Reviews ReviewOpen access 2018 1,686
28 “On Water”: Unique Reactivity of Organic Compounds in Aqueous Suspension Sridhar Narayan, John Muldoon, M. G. Finn et al. · Angewandte Chemie International Edition Open access 21 Apr 2005 1,686
29 Transition metal-catalyzed C–H activation reactions: diastereoselectivity and enantioselectivity Ramesh Giri, Bing‐Feng Shi, Keary M. Engle et al. · Chemical Society Reviews Review 2009 1,674
30 Enantioselective Mannich‐Type Reaction Catalyzed by a Chiral Brønsted Acid Takahiko Akiyama, Junji Itoh, Koji Yokota et al. · Angewandte Chemie International Edition 9 Mar 2004 1,670
31 Beyond Directing Groups: Transition‐Metal‐Catalyzed CH Activation of Simple Arenes Nadine Kuhl, Matthew N. Hopkinson, Joanna Wencel‐Delord et al. · Angewandte Chemie International Edition 20 Sep 2012 1,640
32 Recent developments in natural product synthesis using metal-catalysed C–H bond functionalisation Lindsay McMurray, Fionn O’Hara, Matthew J. Gaunt · Chemical Society Reviews Review 2011 1,630
33 Click-Chemie: diverse chemische Funktionalität mit einer Handvoll guter Reaktionen Hartmuth Christian Kolb, M. G. Finn, Karl Barry Sharpless · Angewandte Chemie Jun 2001 1,621
34 Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery Elizabeth A. Ilardi, Edon Vitaku, Jón T. Njardarson · Journal of Medicinal Chemistry 8 Oct 2013 1,617
35 Recent Advances in the Baylis−Hillman Reaction and Applications Deevi Basavaiah, Anumolu Jaganmohan Rao, Tummanapalli Satyanarayana · Chemical Reviews Review 27 Feb 2003 1,604
36 Transition metal-catalyzed C–H bond functionalizations by the use of diverse directing groups Zhengkai Chen, Binjie Wang, Jitan Zhang et al. · Organic Chemistry Frontiers 2015 1,544
37 C–H activation Robert George Bergman · Nature 21 Mar 2007 1,474
38 Catalytic Functionalization of Indoles in a New Dimension Marco Bandini, Astrid Eichholzer · Angewandte Chemie International Edition 27 Nov 2009 1,432
39 Cu(II)-Catalyzed Functionalizations of Aryl C−H Bonds Using O 2 as an Oxidant Xiao Chen, Xueshi Hao, Charles E. Goodhue et al. · Journal of the American Chemical Society May 2006 1,381
40 Controlling Site Selectivity in Palladium-Catalyzed C–H Bond Functionalization Sharon R. Neufeldt, Melanie Sarah Sanford · Accounts of Chemical Research Open access 3 May 2012 1,371
41 Enamine-Based Organocatalysis with Proline and Diamines: The Development of Direct Catalytic Asymmetric Aldol, Mannich, Michael, and Diels−Alder Reactions Wolfgang Notz, Fujie Tanaka, Carlos F. Barbas · Accounts of Chemical Research 10 Jul 2004 1,369
42 If CH Bonds Could Talk: Selective CH Bond Oxidation Timothy R. Newhouse, Phil S. Baran · Angewandte Chemie International Edition Open access 16 Mar 2011 1,365
43 PhosphinooxazolinesA New Class of Versatile, Modular P,N-Ligands for Asymmetric Catalysis Günter Helmchen, Andreas Pfaltz · Accounts of Chemical Research 5 May 2000 1,300
44 A Predictably Selective Aliphatic C–H Oxidation Reaction for Complex Molecule Synthesis Mark S. Chen, M. Christina White · Science Nov 2007 1,300
45 Copper‐Catalyzed Aerobic Oxidative CH Functionalizations: Trends and Mechanistic Insights Alison E. Wendlandt, Alison M. Suess, Shannon S. Stahl · Angewandte Chemie International Edition 27 Oct 2011 1,290
46 Metal–Ligand Cooperation Julia R. Khusnutdinova, David Milstein · Angewandte Chemie International Edition 7 Sep 2015 1,259
47 Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms? Vincenzo Alterio, Anna Di Fiore, Katia D’Ambrosio et al. · Chemical Reviews ReviewOpen access 18 May 2012 1,237
48 Cobalt-Catalyzed C–H Activation Marc Moselage, Jie Li, Lutz Ackermann · ACS Catalysis 24 Nov 2015 1,230
49 Diaryliodonium Salts: A Journey from Obscurity to Fame Eleanor A. Merritt, Berit Olofsson · Angewandte Chemie International Edition 29 Oct 2009 1,201
50 Prescribed drugs containing nitrogen heterocycles: an overview Majid M. Heravi, Vahideh Zadsirjan · RSC Advances Open access 2020 1,190

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.