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Topic · Organic Chemistry

Synthesis and Catalytic Reactions

Synthesis and Catalytic Reactions is a research topic within Organic Chemistry. Science Explorer counts 32k research works in it since 1950. 9.8% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the catalytic C-H amination reactions, including nitrene transfer methods, enantioselective synthesis of aziridines, and the use of sulfoximines in medicinal chemistry. The research covers various metal-catalyzed approaches and their applications in the synthesis of biologically relevant compounds.

  • Catalytic
  • Amination
  • C-H Bonds
  • Nitrene Transfer
  • Aziridines
  • Metal-Catalyzed
  • Enantioselective
  • Synthesis
  • Sulfoximines
  • Medicinal Chemistry
Research works
32k
fractional, since 1950
In the world top 10%
3.1k
per year above
Top-10% rate
9.8%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-8%
the tick is no change
Largest producer
China
45% of the 10 largest, 2022-now
Synthesis and Catalytic Reactions

Which countries lead Synthesis and Catalytic Reactions research?

By volume, China and India publish the most (1.4k and 491 works in 2022-now).

By volume, 2022-now

  1. 1 China 1.4k works
  2. 2 India 491 works
  3. 3 United States 403 works
  4. 4 Japan 175 works
  5. 5 Germany 152 works
  6. 6 Russia 129 works
  7. 7 Italy 95 works
  8. 8 France 93 works
  9. 9 United Kingdom 79 works
  10. 10 South Korea 74 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 45.4%India: 15.9%United States: 13.0%Japan: 5.6%6 others listed: 20.1%45%largest
China1,406 · 45.4%India491 · 15.9%United States403 · 13.0%Japan175 · 5.6%6 others listed622 · 20.1%

Shares of the rows listed above, not of the whole node.

Which institutions lead Synthesis and Catalytic Reactions research?

By volume in 2022-now, Chinese Academy of Sciences publishes the most Synthesis and Catalytic Reactions research, followed by Russian Academy of Sciences and Centre National de la Recherche Scientifique.

By volume, 2022-now

  1. 1 Chinese Academy of SciencesChina 100 works
  2. 2 Russian Academy of SciencesRussia 52 works
  3. 3 Centre National de la Recherche ScientifiqueFrance 50 works
  4. 4 Sichuan UniversityChina 39 works
  5. 5 University of FlorenceItaly 34 works
  6. 6 Henan Normal UniversityChina 34 works
  7. 7 Council of Scientific and Industrial ResearchIndia 33 works
  8. 8 Nankai UniversityChina 31 works
  9. 9 Academy of Scientific and Innovative ResearchIndia 26 works
  10. 10 Sun Yat-sen UniversityChina 25 works

Who are the leading researchers in Synthesis and Catalytic Reactions?

The most-cited researchers publishing on Synthesis and Catalytic Reactions include Matthew M. Meyerson, Matthias Ernzerhof and George M. Whitesides.

  1. 1 Matthew M. Meyerson United States 280k citations
  2. 2 Matthias Ernzerhof Canada 276k citations
  3. 3 George M. Whitesides United States 267k citations
  4. 4 Wei Huang China 267k citations
  5. 5 Peter John Barnes United Kingdom 225k citations
  6. 6 Stefan Grimme Germany 224k citations
  7. 7 Kai You Wang China 224k citations
  8. 8 George M. Sheldrick Germany 220k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Synthesis and Catalytic Reactions?

The most cited paper in Synthesis and Catalytic Reactions is "A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes" (Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al., 2002), with 11,614 citations. Next come "Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions" (6,127) and "CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals" (2,994).

Most cited papers
#PaperReleasedCitations
1 A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition 15 Jul 2002 11,614
2 Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions Thomas W. Lyons, Melanie Sarah Sanford · Chemical Reviews ReviewOpen access 15 Jan 2010 6,127
3 CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals Junichiro Yamaguchi, Atsushi D. Yamaguchi, Kenichiro Itami · Angewandte Chemie International Edition 6 Aug 2012 2,994
4 Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design Nicholas A. Meanwell · Journal of Medicinal Chemistry Open access 17 Mar 2011 2,856
5 Cross-Dehydrogenative Coupling (CDC): Exploring C−C Bond Formations beyond Functional Group Transformations Chao‐Jun Li · Accounts of Chemical Research 16 Dec 2008 2,780
All 100 most cited papers, with filters and sorting

Where is Synthesis and Catalytic Reactions research done?

The largest centres of Synthesis and Catalytic Reactions research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Chengdu (China). Among places with at least 20 works in it, it is an unusually large share of all research in Xinxiang, Ghaziabad and Changzhou.

Largest cities, 2022-now

  1. 1 BeijingChina 149 works
  2. 2 ShanghaiChina 108 works
  3. 3 GuangzhouChina 73 works
  4. 4 ChengduChina 72 works
  5. 5 HangzhouChina 68 works
  6. 6 NanjingChina 65 works
  7. 7 TianjinChina 56 works
  8. 8 MoscowRussia 45 works
  9. 9 TokyoJapan 44 works
  10. 10 WuhanChina 42 works

Where it is the local speciality

  1. XinxiangCN · 37.0 works36×
  2. GhaziabadIN · 26.2 works15×
  3. ChangzhouCN · 22.4 works13×
  4. PhagwāraIN · 20.9 works12×
  5. FlorenceIT · 31.9 works11×
  6. GuwahatiIN · 25.9 works10×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Synthesis and Catalytic Reactions than the world average.

See Synthesis and Catalytic Reactions on the map

Where is the best place to study Synthesis and Catalytic Reactions?

Among universities, judged by research, Henan Normal University, Yale University and Nankai University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 20.27%fractional works in this field (log) →share of work in the world top 10% →Yale UniversityHenan Normal Univers…Nankai UniversityUniversity of Florence
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Henan Normal UniversityChina 72.123.8%53.6×34 +77.8%
2Yale UniversityUnited States 61.537.5%3.3×11 +10.4%
3Nankai UniversityChina 60.920.3%14.3×31 -10.1%
4University of FlorenceItaly 60.614.4%18.2×34 -30.5%
5RWTH Aachen UniversityGermany 58.913.8%10.2×25 +5.2%
6Southern University of Science and TechnologyChina 58.621.9%8.7×14 -2.1%
7Sichuan UniversityChina 56.013.2%5.5×39 -5.2%
8University of MünsterGermany 50.530.9%8.3×11 -22.3%
9Sun Yat-sen UniversityChina 49.79.4%3.9×25 +20.1%
10ETH ZurichSwitzerland 48.817.5%3.9×9 +33.4%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Synthesis and Catalytic Reactions, country by country

Is Synthesis and Catalytic Reactions research growing?

Output in 2022-2025 was 8% lower than in 2018-2021, peaking in 2015.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Synthesis and Catalytic Reactions as a percentage of every work published that year, 0.016% in 2024.

still counting0.020%0.040%0.060%Synthesis and Catalytic Reactions0.013% in 202519801990200020102020

Fractional works of Synthesis and Catalytic Reactions over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Synthesis and Catalytic Reactions9.7% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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