Most cited papers in Telomeres, Telomerase, and Senescence
What are the most cited papers in Telomeres, Telomerase, and Senescence?
The most cited paper in Telomeres, Telomerase, and Senescence is "The Hallmarks of Aging" (Carlos López-Otı́n, Marı́a A. Blasco, Linda Partridge et al., 2013), with 15,388 citations. Next come "Hallmarks of Cancer: New Dimensions" (9,794) and "DNA methylation age of human tissues and cell types" (7,572).
Showing 50 of 100 papers. Every paper with more than 1,350 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | The Hallmarks of Aging Carlos López-Otı́n, Marı́a A. Blasco, Linda Partridge et al. · Cell | Jun 2013 | 15,388 |
| 2 | Hallmarks of Cancer: New Dimensions Douglas Hanahan · Cancer Discovery | 2022 | 9,794 |
| 3 | DNA methylation age of human tissues and cell types Steve Horvath · Genome biology | 20 Oct 2013 | 7,572 |
| 4 | A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences | 26 Sep 1995 | 7,565 |
| 5 | Specific Association of Human Telomerase Activity with Immortal Cells and Cancer Nam W. Kim, Mieczyslaw A. Piatyszek, Karen R. Prowse et al. · Science | 23 Dec 1994 | 7,190 |
| 6 | Hallmarks of aging: An expanding universe Carlos López-Otı́n, Marı́a A. Blasco, Linda Partridge et al. · Cell | 2023 | 6,477 |
| 7 | The limited in vitro lifetime of human diploid cell strains Leonard Hayflick · Experimental Cell Research | Mar 1965 | 5,907 |
| 8 | Telomeres shorten during ageing of human fibroblasts Calvin B. Harley, A. B. Futcher, Carol W. Greider · Nature | May 1990 | 5,775 |
| 9 | The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression Jean‐Philippe Coppé, Pierre‐Yves Desprez, Ana Krtolica et al. · Annual Review of Pathology Mechanisms of Disease | 2010 | 5,314 |
| 10 | Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell | Mar 1997 | 5,154 |
| 11 | Extension of Life-Span by Introduction of Telomerase into Normal Human Cells Andrea G. Bodnar, Michel M. Ouellette, Maria Frolkis et al. · Science | 16 Jan 1998 | 5,020 |
| 12 | Cellular senescence: when bad things happen to good cells Judith Campisi, Fabrizio d’Adda di Fagagna · Nature Reviews Molecular Cell Biology | Aug 2007 | 4,475 |
| 13 | Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor Jean‐Philippe Coppé · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) | 13 Jan 2009 | 4,254 |
| 14 | Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases Claudio Franceschi, J. Campisi · The Journals of Gerontology Series A | 14 May 2014 | 3,937 |
| 15 | Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders Darren J. Baker, Tobias Wijshake, Tamar Tchkonia et al. · Nature | Nov 2011 | 3,739 |
| 16 | Structure and function of telomeres Elizabeth Helen Blackburn · Nature | Apr 1991 | 3,658 |
| 17 | Telomere measurement by quantitative PCR Richard Cawthon · Nucleic Acids Research | 15 May 2002 | 3,575 |
| 18 | Cellular Senescence: Defining a Path Forward Vassilis G. Gorgoulis et al. · Cell | Oct 2019 | 3,322 |
| 19 | Shelterin: the protein complex that shapes and safeguards human telomeres Titia de Lange · Genes & Development | 15 Sep 2005 | 3,078 |
| 20 | Accelerated telomere shortening in response to life stress Elissa S. Epel, Elizabeth Helen Blackburn, Jue Lin et al. · Proceedings of the National Academy of Sciences | Dec 2004 | 3,020 |
| 21 | Aging, Cellular Senescence, and Cancer Judith Campisi · Annual Review of Physiology | 9 Nov 2012 | 3,009 |
| 22 | Cellular senescence: from physiology to pathology Daniel Muñoz‐Espín, Manuel Serrano · Nature Reviews Molecular Cell Biology | 23 Jun 2014 | 2,889 |
| 23 | Naturally occurring p16Ink4a-positive cells shorten healthy lifespan Darren J. Baker, Bennett G. Childs, Matej Durik et al. · Nature | Feb 2016 | 2,869 |
| 24 | A DNA damage checkpoint response in telomere-initiated senescence Fabrizio d’Adda di Fagagna, Philip M. Reaper, Lorena Clay-Farrace et al. · Nature | Nov 2003 | 2,835 |
| 25 | A survey of telomerase activity in human cancer Jerry W. Shay, Silvia Bacchetti · European Journal of Cancer | Apr 1997 | 2,806 |
| 26 | The role of senescent cells in ageing Jan M. van Deursen · Nature | 20 May 2014 | 2,685 |
| 27 | Hallmarks of Cellular Senescence Alejandra Hernandez‐Segura, Jamil Nehme, Marco Demaria · Trends in Cell Biology | 21 Feb 2018 | 2,670 |
| 28 | Oxidative stress shortens telomeres Thomas von Zglinicki · Trends in Biochemical Sciences | Jul 2002 | 2,560 |
| 29 | The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs Yi Zhun Zhu et al. · Aging Cell | 9 Mar 2015 | 2,539 |
| 30 | Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas Wen Xue, Lars Zender, Cornelius Miething et al. · Nature | 24 Jan 2007 | 2,483 |
| 31 | Mammalian Telomeres End in a Large Duplex Loop Jack D. Griffith, Laurey Comeau, Soraya I. Rosenfield et al. · Cell | May 1999 | 2,449 |
| 32 | Cellular senescence in aging and age-related disease: from mechanisms to therapy Bennett G. Childs, Matej Durik, Darren J. Baker et al. · Nature Medicine | Dec 2015 | 2,410 |
| 33 | Creation of human tumour cells with defined genetic elements William C. Hahn, Christopher M. Counter, Ante S. Lundberg et al. · Nature | 29 Jul 1999 | 2,366 |
| 34 | Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors Judith Campisi · Cell | Feb 2005 | 2,348 |
| 35 | Senolytics improve physical function and increase lifespan in old age Ming Xu et al. · Nature Medicine | 6 Jul 2018 | 2,347 |
| 36 | A complex secretory program orchestrated by the inflammasome controls paracrine senescence Juan Carlos Acosta et al. · Nature Cell Biology | 14 Jun 2013 | 2,339 |
| 37 | Cellular senescence in ageing: from mechanisms to therapeutic opportunities Raffaella Di Micco, Valery Krizhanovsky, Darren J. Baker et al. · Nature Reviews Molecular Cell Biology | 16 Dec 2020 | 2,304 |
| 38 | Telomerase Catalytic Subunit Homologs from Fission Yeast and Human Toru Nakamura, Gregg B. Morin, Karen B. Chapman et al. · Science | 15 Aug 1997 | 2,277 |
| 39 | Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence Masashi Narita, Sabrina Nuñez, Édith Heard et al. · Cell | Jun 2003 | 2,268 |
| 40 | The RNA Component of Human Telomerase Junli Feng, Walter D. Funk, Sy-Shi Wang et al. · Science | Sep 1995 | 2,263 |
| 41 | DNA Damage, Aging, and Cancer Jan H.J. Hoeijmakers · New England Journal of Medicine | 7 Oct 2009 | 2,241 |
| 42 | Telomere length predicts replicative capacity of human fibroblasts. Richard Allsopp, Homayoun Vaziri, Cam Patterson et al. · Proceedings of the National Academy of Sciences | Nov 1992 | 2,236 |
| 43 | Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion Françis Rodier, Jean‐Philippe Coppé, Christopher K. Patil et al. · Nature Cell Biology | 13 Jul 2009 | 2,235 |
| 44 | Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome Shin Yoshimoto, Tze Mun Loo, Koji Atarashi et al. · Nature | 25 Jun 2013 | 2,234 |
| 45 | BRAFE600-associated senescence-like cell cycle arrest of human naevi Chrysiis Michaloglou, Liesbeth C.W. Vredeveld, Marı́a S. Soengas et al. · Nature | Aug 2005 | 2,159 |
| 46 | Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle David Yaffe, Ora Saxel · Nature | Dec 1977 | 2,158 |
| 47 | Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA Marı́a A. Blasco, Han‐Woong Lee, Manoor Prakash Hande et al. · Cell | Oct 1997 | 2,132 |
| 48 | Switching and Signaling at the Telomere Elizabeth Helen Blackburn · Cell | Sep 2001 | 2,121 |
| 49 | Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. Christopher M. Counter, Ariel A. Avilion, Catherine LeFeuvre et al. · The EMBO Journal | May 1992 | 2,119 |
| 50 | Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network Thomas Kuilman, Chrysiis Michaloglou, Liesbeth C.W. Vredeveld et al. · Cell | Jun 2008 | 2,107 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.