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Topic · Physiology

Telomeres, Telomerase, and Senescence

Telomeres, Telomerase, and Senescence is a research topic within Physiology. Science Explorer counts 16k research works in it since 1953. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the mechanisms and implications of cellular senescence, with a focus on telomere dynamics, tumor suppression, inflammation, DNA damage response, and the potential therapeutic role of senolytics in aging-related diseases.

  • Senescence
  • Telomere
  • Tumor Suppression
  • Inflammation
  • Oncogene-induced Senescence
  • DNA Damage Response
  • Senolytics
  • Stem Cells
  • Aging
  • Telomerase
Research works
16k
fractional, since 1953
In the world top 10%
1.6k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+23%
the tick is no change
Largest producer
China
34% of the 10 largest, 2022-now
Telomeres, Telomerase, and Senescence

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Telomeres, Telomerase, and Senescence research?

By volume, China and the United States publish the most (922 and 859 works in 2022-now).

By volume, 2022-now

  1. 1 China 922 works
  2. 2 United States 859 works
  3. 3 United Kingdom 152 works
  4. 4 Japan 148 works
  5. 5 Germany 132 works
  6. 6 India 110 works
  7. 7 France 109 works
  8. 8 Italy 108 works
  9. 9 South Korea 101 works
  10. 10 Spain 99 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 33.7%United States: 31.3%United Kingdom: 5.6%Japan: 5.4%6 others listed: 24.0%34%largest
China922 · 33.7%United States859 · 31.3%United Kingdom152 · 5.6%Japan148 · 5.4%6 others listed658 · 24.0%

Shares of the rows listed above, not of the whole node.

Which institutions lead Telomeres, Telomerase, and Senescence research?

By volume in 2022-now, Mayo Clinic publishes the most Telomeres, Telomerase, and Senescence research, followed by National Institutes of Health and Harvard University.

By volume, 2022-now

  1. 1 Mayo ClinicUnited States 48 works
  2. 2 National Institutes of HealthUnited States 40 works
  3. 3 Harvard UniversityUnited States 34 works
  4. 4 Centre National de la Recherche ScientifiqueFrance 30 works
  5. 5 Sun Yat-sen UniversityChina 29 works
  6. 6 Shanghai Jiao Tong UniversityChina 29 works
  7. 7 Russian Academy of SciencesRussia 28 works
  8. 8 Sichuan UniversityChina 24 works
  9. 9 Huazhong University of Science and TechnologyChina 21 works
  10. 10 Central South UniversityChina 20 works

Who are the leading researchers in Telomeres, Telomerase, and Senescence?

The most-cited researchers publishing on Telomeres, Telomerase, and Senescence include George Davey Smith, Stacey L. Gabriel and Guido Kroemer.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Stacey L. Gabriel United States 402k citations
  3. 3 Guido Kroemer France 386k citations
  4. 4 Bert Vogelstein United States 373k citations
  5. 5 Gad A. Getz United States 364k citations
  6. 6 Elaine R. Mardis United States 346k citations
  7. 7 Hermann Brenner Germany 343k citations
  8. 8 Shizuo Akira Japan 342k citations
  9. 9 Cyrus Cooper United Kingdom 342k citations
  10. 10 Emelia J. Benjamin United States 341k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Telomeres, Telomerase, and Senescence?

The most cited paper in Telomeres, Telomerase, and Senescence is "The Hallmarks of Aging" (Carlos López-Otı́n, Marı́a A. Blasco, Linda Partridge et al., 2013), with 15,388 citations. Next come "Hallmarks of Cancer: New Dimensions" (9,794) and "DNA methylation age of human tissues and cell types" (7,572).

Most cited papers
#PaperReleasedCitations
1 The Hallmarks of Aging Carlos López-Otı́n, Marı́a A. Blasco, Linda Partridge et al. · Cell Open access Jun 2013 15,388
2 Hallmarks of Cancer: New Dimensions Douglas Hanahan · Cancer Discovery Open access 2022 9,794
3 DNA methylation age of human tissues and cell types Steve Horvath · Genome biology Open access 20 Oct 2013 7,572
4 A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences Open access 26 Sep 1995 7,565
5 Specific Association of Human Telomerase Activity with Immortal Cells and Cancer Nam W. Kim, Mieczyslaw A. Piatyszek, Karen R. Prowse et al. · Science 23 Dec 1994 7,190
All 100 most cited papers, with filters and sorting

Where is Telomeres, Telomerase, and Senescence research done?

The largest centres of Telomeres, Telomerase, and Senescence research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Paris (France). Among places with at least 20 works in it, it is an unusually large share of all research in Bethesda and San Francisco.

Largest cities, 2022-now

  1. 1 BeijingChina 102 works
  2. 2 ShanghaiChina 81 works
  3. 3 GuangzhouChina 70 works
  4. 4 ParisFrance 54 works
  5. 5 TokyoJapan 52 works
  6. 6 LondonUnited Kingdom 52 works
  7. 7 New YorkUnited States 44 works
  8. 8 MoscowRussia 44 works
  9. 9 SeoulSouth Korea 41 works
  10. 10 WuhanChina 41 works

Where it is the local speciality

  1. BethesdaUS · 27.4 works6.4×
  2. San FranciscoUS · 25.3 works5.4×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Telomeres, Telomerase, and Senescence than the world average.

See Telomeres, Telomerase, and Senescence on the map

Where is the best place to study Telomeres, Telomerase, and Senescence?

Among universities, judged by research, Rockefeller University, Harvard University and Imperial College London score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%25%50%75%mean 18.61%fractional works in this field (log) →share of work in the world top 10% →Rockefeller UniversityImperial College Lon…Harvard UniversityShanghai Jiao Tong U…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Rockefeller UniversityUnited States 63.162.8%43.8×8 +132.9%
2Harvard UniversityUnited States 61.815.9%3.4×34 +19.1%
3Imperial College LondonUnited Kingdom 50.226.3%4.1×13 +44.5%
4Shanghai Jiao Tong UniversityChina 49.012.4%3.2×29 +208.9%
5Sun Yat-sen UniversityChina 48.99.9%4.5×29 +127.4%
6Sichuan UniversityChina 44.711.1%3.4×24 +192.5%
7Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 44.614.1%6.0×20 +72.4%
8Huazhong University of Science and TechnologyChina 42.515.3%3.6×21 +46.9%
9Central South UniversityChina 40.812.8%3.3×20 +89.0%
10University of California, San FranciscoUnited States 38.95.5%7.4×16 -4.9%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Telomeres, Telomerase, and Senescence, country by country

Is Telomeres, Telomerase, and Senescence research growing?

Output in 2022-2025 was 23% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Telomeres, Telomerase, and Senescence.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Telomeres, Telomerase, and Senescence as a percentage of every work published that year, 0.014% in 2024.

still counting0.010%0.020%0.030%Telomeres, Telomerase, and Senescence0.016% in 202519801990200020102020

Fractional works of Telomeres, Telomerase, and Senescence over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Telomeres, Telomerase, and Senescence10.5% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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