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Topic · Physiology

Nitric Oxide and Endothelin Effects

Nitric Oxide and Endothelin Effects is a research topic within Physiology. Science Explorer counts 59k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the role of nitric oxide in health and disease, particularly focusing on its involvement in endothelial dysfunction, oxidative stress, cardiovascular diseases, and the regulation of vascular function. It also delves into the impact of nitric oxide on inflammation, atherosclerosis, and mitochondrial biogenesis.

  • Nitric Oxide
  • Endothelial Dysfunction
  • Oxidative Stress
  • Cardiovascular Diseases
  • Reactive Oxygen Species
  • NAD(P)H Oxidase
  • Atherosclerosis
  • Vascular Function
  • Inflammation
  • Mitochondrial Biogenesis
Research works
59k
fractional, since 1950
In the world top 10%
5.9k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-20%
the tick is no change
Largest producer
United States
33% of the 10 largest, 2022-now
Nitric Oxide and Endothelin Effects

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Nitric Oxide and Endothelin Effects research?

By volume, the United States and China publish the most (737 and 647 works in 2022-now).

By volume, 2022-now

  1. 1 United States 737 works
  2. 2 China 647 works
  3. 3 Germany 139 works
  4. 4 Japan 128 works
  5. 5 India 121 works
  6. 6 Russia 109 works
  7. 7 United Kingdom 109 works
  8. 8 Brazil 102 works
  9. 9 Italy 90 works
  10. 10 France 61 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 32.9%China: 28.9%Germany: 6.2%Japan: 5.7%6 others listed: 26.4%33%largest
United States737 · 32.9%China647 · 28.9%Germany139 · 6.2%Japan128 · 5.7%6 others listed591 · 26.4%

Shares of the rows listed above, not of the whole node.

Which institutions lead Nitric Oxide and Endothelin Effects research?

By volume in 2022-now, Russian Academy of Sciences publishes the most Nitric Oxide and Endothelin Effects research, followed by Harvard University and Medical College of Wisconsin.

By volume, 2022-now

  1. 1 Russian Academy of SciencesRussia 45 works
  2. 2 Harvard UniversityUnited States 19 works
  3. 3 Medical College of WisconsinUnited States 17 works
  4. 4 Universidade de São PauloBrazil 16 works
  5. 5 Centre National de la Recherche ScientifiqueFrance 15 works
  6. 6 Vanderbilt UniversityUnited States 14 works
  7. 7 Peking UniversityChina 13 works
  8. 8 National Institutes of HealthUnited States 13 works
  9. 9 Shanghai Jiao Tong UniversityChina 13 works
  10. 10 University of North Carolina at Chapel HillUnited States 13 works

Who are the leading researchers in Nitric Oxide and Endothelin Effects?

The most-cited researchers publishing on Nitric Oxide and Endothelin Effects include George Davey Smith, Mark J. Daly and John J.V. McMurray.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Mark J. Daly United States 403k citations
  3. 3 John J.V. McMurray United Kingdom 349k citations
  4. 4 Hermann Brenner Germany 343k citations
  5. 5 Shizuo Akira Japan 342k citations
  6. 6 Emelia J. Benjamin United States 341k citations
  7. 7 Giuseppe Remuzzi Italy 328k citations
  8. 8 Gregory Y.H. Lip United Kingdom 311k citations
  9. 9 Salim Yusuf Canada 294k citations
  10. 10 Frank B. Hu United States 281k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Nitric Oxide and Endothelin Effects?

The most cited paper in Nitric Oxide and Endothelin Effects is "Nitric oxide: physiology, pathophysiology, and pharmacology." (Salvador Moncada, Richard M. J. Palmer, E.A. Higgs, 1991), with 15,612 citations. Next come "Superoxide Dismutase" (12,906) and "The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine" (12,123).

Most cited papers
#PaperReleasedCitations
1 Nitric oxide: physiology, pathophysiology, and pharmacology. Salvador Moncada, Richard M. J. Palmer, E.A. Higgs · Pharmacological Reviews Jun 1991 15,612
2 Superoxide Dismutase Joe M. McCord, Irwin Fridovich · Journal of Biological Chemistry Open access Nov 1969 12,906
3 The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine Robert F. Furchgott, John V. Zawadzki · Nature Nov 1980 12,123
4 A novel potent vasoconstrictor peptide produced by vascular endothelial cells Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura et al. · Nature Open access Mar 1988 10,827
5 Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor Richard M. J. Palmer, Anthony G. Ferrige, Salvador Moncada · Nature Jun 1987 10,799
All 99 most cited papers, with filters and sorting

Where is Nitric Oxide and Endothelin Effects research done?

The largest centres of Nitric Oxide and Endothelin Effects research in 2022-now are Beijing (China), Moscow (Russia), Shanghai (China) and Nanjing (China).

Largest cities, 2022-now

  1. 1 BeijingChina 76 works
  2. 2 MoscowRussia 51 works
  3. 3 ShanghaiChina 48 works
  4. 4 NanjingChina 39 works
  5. 5 LondonUnited Kingdom 32 works
  6. 6 GuangzhouChina 31 works
  7. 7 São PauloBrazil 31 works
  8. 8 TokyoJapan 28 works
  9. 9 ParisFrance 24 works
  10. 10 HangzhouChina 24 works
See Nitric Oxide and Endothelin Effects on the map

Where is the best place to study Nitric Oxide and Endothelin Effects?

Among universities, judged by research, Universidad de la República de Uruguay, Harvard University and Vanderbilt University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 16.41%fractional works in this field (log) →share of work in the world top 10% →Zhejiang UniversityUniversidad de la Re…Vanderbilt UniversityHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Universidad de la República de UruguayUruguay 67.419.5%12.4×8 +15.8%
2Harvard UniversityUnited States 63.413.8%2.2×19 -22.7%
3Vanderbilt UniversityUnited States 56.514.0%7.3×14 +53.4%
4Zhejiang UniversityChina 53.133.1%1.5×11 +28.2%
5Medical College of WisconsinUnited States 50.78.7%23.5×18 -26.7%
6University of Alabama at BirminghamUnited States 47.113.2%9.6×12 -21.7%
7Peking UniversityChina 47.016.2%2.5×13 +61.6%
8Indiana UniversityUnited States 44.917.7%4.7×12 +1.7%
9Karolinska InstitutetSweden 41.213.3%6.9×10 -49.0%
10University of PittsburghUnited States 38.114.6%5.0×10 -40.5%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Nitric Oxide and Endothelin Effects, country by country

Is Nitric Oxide and Endothelin Effects research growing?

Output in 2022-2025 was 20% lower than in 2018-2021, peaking in 1997.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Nitric Oxide and Endothelin Effects as a percentage of every work published that year, 0.011% in 2024.

still counting0.10%0.20%0.30%Nitric Oxide and Endothelin Effects0.012% in 202519801990200020102020

Fractional works of Nitric Oxide and Endothelin Effects over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Nitric Oxide and Endothelin Effects10.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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