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Topic · Physiology

Lysosomal Storage Disorders Research

Lysosomal Storage Disorders Research is a research topic within Physiology. Science Explorer counts 22k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the diverse aspects of lysosomal storage disorders, including enzyme replacement therapy, genetic mutations, and the impact on various diseases such as Gaucher disease, Fabry disease, Niemann-Pick disease, and Parkinson's disease. It also delves into the underlying mechanisms related to cholesterol metabolism and neuronal ceroid lipofuscinoses.

  • Lysosomal Storage Disorders
  • Enzyme Replacement Therapy
  • Gaucher Disease
  • Fabry Disease
  • Niemann-Pick Disease
  • Parkinson's Disease
  • Glucocerebrosidase Mutations
  • Cholesterol Metabolism
  • Neuronal Ceroid Lipofuscinoses
  • Mucopolysaccharidoses
Research works
22k
fractional, since 1950
In the world top 10%
2.2k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+0%
the tick is no change
Largest producer
United States
33% of the 10 largest, 2022-now
Lysosomal Storage Disorders Research

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Lysosomal Storage Disorders Research research?

By volume, the United States and China publish the most (857 and 336 works in 2022-now).

By volume, 2022-now

  1. 1 United States 857 works
  2. 2 China 336 works
  3. 3 Italy 244 works
  4. 4 United Kingdom 204 works
  5. 5 Japan 188 works
  6. 6 Brazil 179 works
  7. 7 Germany 175 works
  8. 8 India 153 works
  9. 9 France 126 works
  10. 10 Spain 117 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 33.2%China: 13.0%Italy: 9.5%United Kingdom: 7.9%6 others listed: 36.4%33%largest
United States857 · 33.2%China336 · 13.0%Italy244 · 9.5%United Kingdom204 · 7.9%6 others listed938 · 36.4%

Shares of the rows listed above, not of the whole node.

Which institutions lead Lysosomal Storage Disorders Research research?

By volume in 2022-now, National Institutes of Health publishes the most Lysosomal Storage Disorders Research research, followed by University College London and Sanofi (France).

By volume, 2022-now

  1. 1 National Institutes of HealthUnited States 47 works
  2. 2 University College LondonUnited Kingdom 39 works
  3. 3 Sanofi (France)France 33 works
  4. 4 Harvard UniversityUnited States 22 works
  5. 5 Universidade Federal do Rio Grande do SulBrazil 22 works
  6. 6 Universität HamburgGermany 21 works
  7. 7 Centre National de la Recherche ScientifiqueFrance 20 works
  8. 8 Russian Academy of SciencesRussia 18 works
  9. 9 Erasmus University RotterdamNetherlands 18 works
  10. 10 Duke UniversityUnited States 17 works

Who are the leading researchers in Lysosomal Storage Disorders Research?

The most-cited researchers publishing on Lysosomal Storage Disorders Research include Eric S. Lander, Mark J. Daly and Guido Kroemer.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 Mark J. Daly United States 403k citations
  3. 3 Guido Kroemer France 386k citations
  4. 4 Jun Wang China 340k citations
  5. 5 Giuseppe Remuzzi Italy 328k citations
  6. 6 Gregory Y.H. Lip United Kingdom 311k citations
  7. 7 Matthias Mann Germany 308k citations
  8. 8 Sudhir Kumar United States 295k citations
  9. 9 Richard A. Gibbs United States 292k citations
  10. 10 John Q. Trojanowski United States 286k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Lysosomal Storage Disorders Research?

The most cited paper in Lysosomal Storage Disorders Research is "Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease" (Valentina Cappello, Laura Marchetti, Paola Parlanti et al., 2016), with 13,289 citations. Next come "Parkinson's disease" (3,905) and "Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice" (3,905).

Most cited papers
#PaperReleasedCitations
1 Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease Valentina Cappello, Laura Marchetti, Paola Parlanti et al. · Scientific Reports Open access 11 Nov 2016 13,289
2 Parkinson's disease Bastiaan R. Bloem, Michael S. Okun, Christine Klein · The Lancet Open access 11 Apr 2021 3,905
3 Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice Taichi Hara, Kenji D. Nakamura, Makoto Matsui et al. · Nature 19 Apr 2006 3,905
4 TFEB Links Autophagy to Lysosomal Biogenesis Carmine Settembre, Chiara Di Malta, Vinicia Assunta Polito et al. · Science Open access 26 May 2011 3,389
5 Mechanisms of mitophagy Richard J. Youle, Derek P. Narendra · Nature Reviews Molecular Cell Biology ReviewOpen access 22 Dec 2010 3,286
All 100 most cited papers, with filters and sorting

Where is Lysosomal Storage Disorders Research research done?

The largest centres of Lysosomal Storage Disorders Research research in 2022-now are London (United Kingdom), Paris (France), Beijing (China) and Tokyo (Japan). Among places with at least 20 works in it, it is an unusually large share of all research in Bethesda.

Largest cities, 2022-now

  1. 1 LondonUnited Kingdom 74 works
  2. 2 ParisFrance 58 works
  3. 3 BeijingChina 55 works
  4. 4 TokyoJapan 51 works
  5. 5 BethesdaUnited States 45 works
  6. 6 RomeItaly 42 works
  7. 7 São PauloBrazil 37 works
  8. 8 MadridSpain 36 works
  9. 9 New YorkUnited States 34 works
  10. 10 ShanghaiChina 32 works

Where it is the local speciality

  1. BethesdaUS · 44.8 works10×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Lysosomal Storage Disorders Research than the world average.

See Lysosomal Storage Disorders Research on the map

Where is the best place to study Lysosomal Storage Disorders Research?

Among universities, judged by research, University College London, Erasmus University Rotterdam and Harvard University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 14.64%fractional works in this field (log) →share of work in the world top 10% →Northwestern Univers…University College L…Harvard UniversityErasmus University R…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1University College LondonUnited Kingdom 77.214.1%7.8×39 -25.4%
2Erasmus University RotterdamNetherlands 62.010.0%10.9×18 +10.1%
3Harvard UniversityUnited States 59.711.2%2.2×22 -14.4%
4Northwestern UniversityUnited States 57.121.6%4.9×13 -25.4%
5McGill UniversityCanada 56.915.6%4.5×14 -6.6%
6Johns Hopkins UniversityUnited States 55.716.5%2.2×11 +14.4%
7University of AmsterdamNetherlands 55.19.4%4.8×9 +67.9%
8University of California, San FranciscoUnited States 54.921.3%4.6×10 -30.0%
9University of MilanItaly 54.015.4%5.8×12 +27.1%
10University of PaduaItaly 53.711.3%5.4×14 +31.2%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Lysosomal Storage Disorders Research, country by country

Is Lysosomal Storage Disorders Research research growing?

Output in 2022-2025 was 0% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Lysosomal Storage Disorders Research.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Lysosomal Storage Disorders Research as a percentage of every work published that year, 0.014% in 2024.

still counting0.020%0.040%0.060%Lysosomal Storage Disorders Research0.015% in 202519801990200020102020

Fractional works of Lysosomal Storage Disorders Research over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Lysosomal Storage Disorders Research9.8% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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