Most cited papers in Tuberous Sclerosis Complex Research
What are the most cited papers in Tuberous Sclerosis Complex Research?
The most cited paper in Tuberous Sclerosis Complex Research is "Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing" (Marco Gerlinger et al., 2012), with 7,931 citations. Next come "The 2015 World Health Organization Classification of Lung Tumors" (4,651) and "Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma" (3,671).
Showing 50 of 100 papers. Every paper with more than 553 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing Marco Gerlinger et al. · New England Journal of Medicine | 7 Mar 2012 | 7,931 |
| 2 | The 2015 World Health Organization Classification of Lung Tumors William David Travis, Elisabeth M. Brambilla, Andrew Gordon Nicholson et al. · Journal of Thoracic Oncology | 21 Aug 2015 | 4,651 |
| 3 | Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma Gary R. Hudes, Michael Anthony Carducci, Piotr Tomczak et al. · New England Journal of Medicine | 30 May 2007 | 3,671 |
| 4 | TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling Ken Inoki, Yong Li, Tianquan Zhu et al. · Nature Cell Biology | 12 Aug 2002 | 3,104 |
| 5 | Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial Robert John Motzer, Bernard J. Escudier, Stéphane Marie. Oudard et al. · The Lancet | 23 Jul 2008 | 3,036 |
| 6 | Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling Ken Inoki, Yong Li, Tian Xu et al. · Genes & Development | 17 Jul 2003 | 1,947 |
| 7 | The Tuberous Sclerosis Complex Peter B. Crino, Katherine L. Nathanson, Elizabeth P. Henske · New England Journal of Medicine | 27 Sep 2006 | 1,793 |
| 8 | The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1 Ingmar Blümcke et al. · Epilepsia | 10 Nov 2010 | 1,764 |
| 9 | Identification of the Tuberous Sclerosis Gene TSC1 on Chromosome 9q34 Marjon van Slegtenhorst et al. · Science | 8 Aug 1997 | 1,675 |
| 10 | Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway Brendan D. Manning, Andrew R. Tee, M. Nicole Logsdon et al. · Molecular Cell | Jul 2002 | 1,568 |
| 11 | Pten is essential for embryonic development and tumour suppression Antonio Di Cristofano, Bárbara Pesce, Carlos Cordon‐Cardo et al. · Nature Genetics | Aug 1998 | 1,532 |
| 12 | Tuberous Sclerosis Complex Diagnostic Criteria Update: Recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference Hope Northrup et al. · Pediatric Neurology | 19 Sep 2013 | 1,524 |
| 13 | TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth Ken Inoki, Hongjiao Ouyang, Tianqing Zhu et al. · Cell | Sep 2006 | 1,409 |
| 14 | Rapamycin: One Drug, Many Effects Jing Li, Sang Gyun Kim, John Blenis · Cell Metabolism | 6 Feb 2014 | 1,325 |
| 15 | The Diagnostic Evaluation and Multidisciplinary Management of Neurofibromatosis 1 and Neurofibromatosis 2 David H. Gutmann · JAMA | 2 Jul 1997 | 1,308 |
| 16 | Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis John J. Bissler, Francis X. McCormack, Lisa R. Young et al. · New England Journal of Medicine | 9 Jan 2008 | 1,280 |
| 17 | Phosphorylation and Functional Inactivation of TSC2 by Erk Li Ma, Zhenbang Chen, Hediye Erdjument‐Bromage et al. · Cell | Apr 2005 | 1,274 |
| 18 | Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression Diane C. Fingar, John Blenis · Oncogene | 19 Apr 2004 | 1,259 |
| 19 | The TSC1–TSC2 complex: a molecular switchboard controlling cell growth Jingxiang Huang, Brendan D. Manning · Biochemical Journal | 14 May 2008 | 1,253 |
| 20 | Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb Andrew R. Tee, Brendan D. Manning, Philippe P. Roux et al. · Current Biology | Aug 2003 | 1,225 |
| 21 | Phase 3 trial of everolimus for metastatic renal cell carcinoma Robert John Motzer, Bernard J. Escudier, Stéphane Marie. Oudard et al. · Cancer | 14 Jun 2010 | 1,148 |
| 22 | Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis Francis X. McCormack et al. · New England Journal of Medicine | 16 Mar 2011 | 1,131 |
| 23 | The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins Laura S. Harrington, Greg M. Findlay, Alex Gray et al. · The Journal of Cell Biology | 12 Jul 2004 | 1,124 |
| 24 | Tuberous sclerosis Paolo Curatolo, Roberta Bombardieri, Sergiusz Jóźwiak · The Lancet | Aug 2008 | 1,107 |
| 25 | Tuberous Sclerosis Complex Consensus Conference: Revised Clinical Diagnostic Criteria E. Steve Roach, Manuel Rodriguez Gomez, Hope Northrup · Journal of Child Neurology | Dec 1998 | 1,087 |
| 26 | Focal dysplasia of the cerebral cortex in epilepsy David C. Taylor, Murray A. Falconer, C.J. Bruton et al. · Journal of Neurology Neurosurgery & Psychiatry | Aug 1971 | 1,074 |
| 27 | Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2 Attila Garami, Fried J. T. Zwartkruis, Takahiro Nobukuni et al. · Molecular Cell | Jun 2003 | 1,059 |
| 28 | Rheb Binds and Regulates the mTOR Kinase Samuel Long, Yenshou Lin, Sara Ortiz-Vega et al. · Current Biology | Apr 2005 | 1,017 |
| 29 | Mutational Analysis in a Cohort of 224 Tuberous Sclerosis Patients Indicates Increased Severity of TSC2, Compared with TSC1, Disease in Multiple Organs Sandra L. Dabora, Sergiusz Jóźwiak, David Neal Franz et al. · The American Journal of Human Genetics | 2001 | 1,014 |
| 30 | Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis Darcy A. Krueger, Marguerite M. Caré, Katherine Holland et al. · New England Journal of Medicine | 3 Nov 2010 | 1,012 |
| 31 | Langerhans'-Cell Histiocytosis (Histiocytosis X) -- A Clonal Proliferative Disease Cheryl L. Willman, Lambert Busque, Barbara B. Griffith et al. · New England Journal of Medicine | 21 Jul 1994 | 1,010 |
| 32 | Perivascular Epithelioid Cell Neoplasms of Soft Tissue and Gynecologic Origin Andrew L. Folpe, Thomas Mentzel, Hans‐Anton Lehr et al. · The American Journal of Surgical Pathology | Dec 2005 | 996 |
| 33 | Dysregulation of the TSC-mTOR pathway in human disease Ken Inoki, Michael Nino Corradetti, Kun‐Liang Guan · Nature Genetics | 28 Dec 2004 | 985 |
| 34 | Akt regulates growth by directly phosphorylating Tsc2 Christopher John Potter, Laura G. Pedraza, Tian Xu · Nature Cell Biology | 12 Aug 2002 | 966 |
| 35 | Terminology and classification of the cortical dysplasias André Palmini, Imad Najm, GIULIANO AVANZINI et al. · Neurology | 23 Mar 2004 | 955 |
| 36 | Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome Michael L. Nickerson, Michelle B. Warren, Jorge R. Toro et al. · Cancer Cell | Aug 2002 | 946 |
| 37 | Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins Yong Zhang, Xinsheng Gao, Leslie J. Saucedo et al. · Nature Cell Biology | 27 May 2003 | 939 |
| 38 | Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice Peter T. Tsai, Court Hull, YunXiang Chu et al. · Nature | 29 Jun 2012 | 935 |
| 39 | 2004 WHO Classification of the Renal Tumors of the Adults Antonio López-Beltrán, Marina Scarpelli, Rodolfo Montironi et al. · European Urology | 18 Jan 2006 | 912 |
| 40 | The PTEN–PI3K pathway: of feedbacks and cross-talks Arkaitz Carracedo, Pier Paolo Pandolfi · Oncogene | 15 Sep 2008 | 904 |
| 41 | Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial John J. Bissler, John Christopher Kingswood, Elżbieta Radzikowska et al. · The Lancet | 11 Jan 2013 | 893 |
| 42 | Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis Dan Ehninger, Sangyeul Han, Carrie Shilyansky et al. · Nature Medicine | 22 Jun 2008 | 878 |
| 43 | Tuberous Sclerosis Complex Surveillance and Management: Recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference Darcy A. Krueger et al. · Pediatric Neurology | 19 Sep 2013 | 867 |
| 44 | Regulation of mTORC1 by PI3K signaling Christian C. Dibble, Lewis C. Cantley · Trends in Cell Biology | 6 Jul 2015 | 866 |
| 45 | Tuberous sclerosis complex Elizabeth P. Henske, Sergiusz Jóźwiak, John Christopher Kingswood et al. · Nature Reviews Disease Primers | 26 May 2016 | 857 |
| 46 | The Akt-mTOR tango and its relevance to cancer Nissim Hay · Cancer Cell | Sep 2005 | 847 |
| 47 | The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway Lynne Chantranupong, Sonia M. Scaria, Robert A. Saxton et al. · Cell | Mar 2016 | 846 |
| 48 | Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling Andrew R. Tee, Diane C. Fingar, Brendan D. Manning et al. · Proceedings of the National Academy of Sciences | 23 Sep 2002 | 833 |
| 49 | Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: an international consensus recommendation Eric Legius et al. · Genetics in Medicine | 4 Jun 2021 | 832 |
| 50 | Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies O. Jameel Shah, Zhiyong Wang, Tony R. Hunter · Current Biology | Sep 2004 | 805 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.