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Topic · Physiology

Tuberous Sclerosis Complex Research

Tuberous Sclerosis Complex Research is a research topic within Physiology. Science Explorer counts 12k research works in it since 1950. 10.3% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on Tuberous Sclerosis Complex (TSC) and related disorders, including Lymphangioleiomyomatosis and Angiomyolipoma. It covers various aspects such as genetic mutations, neurological manifestations, use of mTOR inhibitors, diagnostic criteria, and the role of hamartin and tuberin proteins. Additionally, it explores the association with epilepsy and cognitive impairment.

  • Tuberous Sclerosis Complex
  • Lymphangioleiomyomatosis
  • Angiomyolipoma
  • mTOR Inhibitors
  • Neurological Manifestations
  • Genetic Mutations
  • Epilepsy
  • Diagnostic Criteria
  • Hamartin and Tuberin Proteins
  • Cognitive Impairment
Research works
12k
fractional, since 1950
In the world top 10%
1.3k
per year above
Top-10% rate
10.3%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+13%
the tick is no change
Largest producer
United States
34% of the 10 largest, 2022-now
Tuberous Sclerosis Complex Research

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Tuberous Sclerosis Complex Research research?

By volume, the United States and China publish the most (652 and 468 works in 2022-now).

By volume, 2022-now

  1. 1 United States 652 works
  2. 2 China 468 works
  3. 3 India 180 works
  4. 4 Japan 143 works
  5. 5 Italy 96 works
  6. 6 Germany 87 works
  7. 7 United Kingdom 79 works
  8. 8 Türkiye 69 works
  9. 9 France 66 works
  10. 10 Canada 61 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 34.3%China: 24.6%India: 9.5%Japan: 7.5%6 others listed: 24.1%34%largest
United States652 · 34.3%China468 · 24.6%India180 · 9.5%Japan143 · 7.5%6 others listed458 · 24.1%

Shares of the rows listed above, not of the whole node.

Which institutions lead Tuberous Sclerosis Complex Research research?

By volume in 2022-now, Harvard University publishes the most Tuberous Sclerosis Complex Research research, followed by University of Cincinnati and Mayo Clinic.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 41 works
  2. 2 University of CincinnatiUnited States 26 works
  3. 3 Mayo ClinicUnited States 24 works
  4. 4 All India Institute of Medical SciencesIndia 21 works
  5. 5 Sichuan UniversityChina 21 works
  6. 6 National Institutes of HealthUnited States 20 works
  7. 7 Capital Medical UniversityChina 17 works
  8. 8 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 17 works
  9. 9 University of TorontoCanada 15 works
  10. 10 Shanghai Jiao Tong UniversityChina 15 works

Who are the leading researchers in Tuberous Sclerosis Complex Research?

The most-cited researchers publishing on Tuberous Sclerosis Complex Research include Gad A. Getz, Jun Wang and Giuseppe Remuzzi.

  1. 1 Gad A. Getz United States 364k citations
  2. 2 Jun Wang China 340k citations
  3. 3 Giuseppe Remuzzi Italy 328k citations
  4. 4 Matthew M. Meyerson United States 280k citations
  5. 5 Gordon Brent Mills United States 265k citations
  6. 6 Marco A. Marra Canada 245k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Tuberous Sclerosis Complex Research?

The most cited paper in Tuberous Sclerosis Complex Research is "Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing" (Marco Gerlinger et al., 2012), with 7,931 citations. Next come "The 2015 World Health Organization Classification of Lung Tumors" (4,651) and "Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma" (3,671).

Most cited papers
#PaperReleasedCitations
1 Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing Marco Gerlinger et al. · New England Journal of Medicine Open access 7 Mar 2012 7,931
2 The 2015 World Health Organization Classification of Lung Tumors William David Travis, Elisabeth M. Brambilla, Andrew Gordon Nicholson et al. · Journal of Thoracic Oncology Open access 21 Aug 2015 4,651
3 Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma Gary R. Hudes, Michael Anthony Carducci, Piotr Tomczak et al. · New England Journal of Medicine 30 May 2007 3,671
4 TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling Ken Inoki, Yong Li, Tianquan Zhu et al. · Nature Cell Biology 12 Aug 2002 3,104
5 Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial Robert John Motzer, Bernard J. Escudier, Stéphane Marie. Oudard et al. · The Lancet 23 Jul 2008 3,036
All 100 most cited papers, with filters and sorting

Where is Tuberous Sclerosis Complex Research research done?

The largest centres of Tuberous Sclerosis Complex Research research in 2022-now are Beijing (China), Tokyo (Japan), Guangzhou (China) and Shanghai (China). Among places with at least 20 works in it, it is an unusually large share of all research in Cincinnati and Bethesda.

Largest cities, 2022-now

  1. 1 BeijingChina 73 works
  2. 2 TokyoJapan 38 works
  3. 3 GuangzhouChina 34 works
  4. 4 ShanghaiChina 33 works
  5. 5 BostonUnited States 33 works
  6. 6 New YorkUnited States 32 works
  7. 7 LondonUnited Kingdom 31 works
  8. 8 ChengduChina 28 works
  9. 9 ParisFrance 27 works
  10. 10 CincinnatiUnited States 26 works

Where it is the local speciality

  1. CincinnatiUS · 26.4 works13×
  2. BethesdaUS · 22.0 works6.9×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Tuberous Sclerosis Complex Research than the world average.

See Tuberous Sclerosis Complex Research on the map

Where is the best place to study Tuberous Sclerosis Complex Research?

Among universities, judged by research, Harvard University, University of Cincinnati and University College Dublin score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 17.59%fractional works in this field (log) →share of work in the world top 10% →Harvard UniversityUniversity College D…University of Alabam…University of Cincin…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 86.026.1%5.6×41 -14.9%
2University of CincinnatiUnited States 72.515.3%19.0×26 +16.4%
3University College DublinIreland 63.824.5%9.1×11 +88.7%
4University of Alabama at BirminghamUnited States 55.421.8%8.4×10 +86.3%
5University of TorontoCanada 53.013.6%3.2×15 +24.3%
6Sichuan UniversityChina 49.814.4%4.0×21 +64.9%
7Stanford UniversityUnited States 47.314.6%3.6×12 +79.8%
8Capital Medical UniversityChina 45.312.0%6.9×17 +27.6%
9University of PennsylvaniaUnited States 44.624.1%3.3×8 +2.1%
10Columbia UniversityUnited States 43.89.5%4.0×10 +104.3%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Tuberous Sclerosis Complex Research, country by country

Is Tuberous Sclerosis Complex Research research growing?

Output in 2022-2025 was 13% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Tuberous Sclerosis Complex Research.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Tuberous Sclerosis Complex Research as a percentage of every work published that year, 0.0095% in 2024.

still counting0.010%0.020%Tuberous Sclerosis Complex Research0.012% in 202519801990200020102020

Fractional works of Tuberous Sclerosis Complex Research over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Tuberous Sclerosis Complex Research10.2% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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