Institution · Open Targets
Most cited papers from Open Targets
What are the most cited papers from Open Targets?
The most cited paper from Open Targets is "COSMIC: the Catalogue Of Somatic Mutations In Cancer" (John G. Tate et al., 2018), with 5,379 citations. Next come "The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019" (4,675) and "Applications of machine learning in drug discovery and development" (3,274).
Showing 50 of 60 papers. Every paper with more than 135 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | COSMIC: the Catalogue Of Somatic Mutations In Cancer John G. Tate et al. · Nucleic Acids Research | 11 Oct 2018 | 5,379 |
| 2 | The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019 Annalisa Buniello et al. · Nucleic Acids Research | 25 Oct 2018 | 4,675 |
| 3 | Applications of machine learning in drug discovery and development Jessica J. Vamathevan, Dominic A. Clark, Paul Czodrowski et al. · Nature Reviews Drug Discovery | 11 Apr 2019 | 3,274 |
| 4 | The Reactome Pathway Knowledgebase Antonio Fabregat et al. · Nucleic Acids Research | 26 Oct 2017 | 3,234 |
| 5 | The reactome pathway knowledgebase 2022 Marc E. Gillespie et al. · Nucleic Acids Research | 13 Oct 2021 | 2,621 |
| 6 | ChEMBL: towards direct deposition of bioassay data David Méndez et al. · Nucleic Acids Research | 18 Oct 2018 | 2,540 |
| 7 | The ChEMBL database in 2017 Anna Gaulton, Anne Hersey, Michał Nowotka et al. · Nucleic Acids Research | 31 Oct 2016 | 2,483 |
| 8 | The reactome pathway knowledgebase Bijay Jassal et al. · Nucleic Acids Research | 21 Oct 2019 | 2,384 |
| 9 | Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target Laurent Peyrin‐Biroulet et al. · The American Journal of Gastroenterology | 25 Aug 2015 | 1,861 |
| 10 | The NHGRI-EBI GWAS Catalog: knowledgebase and deposition resource Elliot Sollis et al. · Nucleic Acids Research | 20 Oct 2022 | 1,820 |
| 11 | The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers Zbysław Sońdka, Sally Bamford, Charlotte G. Cole et al. · Nature reviews. Cancer | 6 Oct 2018 | 1,800 |
| 12 | The Reactome Pathway Knowledgebase 2024 Marija Orlic-Milacic et al. · Nucleic Acids Research | 20 Oct 2023 | 1,522 |
| 13 | Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens Fiona M. Behan et al. · Nature | 10 Apr 2019 | 1,479 |
| 14 | Benchmark and integration of resources for the estimation of human transcription factor activities Luz García‐Alonso, Christian H. Holland, Mahmoud M. Ibrahim et al. · Genome Research | 24 Jul 2019 | 1,246 |
| 15 | Mapping the human genetic architecture of COVID-19 COVID-19 Host Genetics Initiative et al. · Nature | 8 Jul 2021 | 1,130 |
| 16 | A cellular census of human lungs identifies novel cell states in health and in asthma Felipe A. Vieira Braga et al. · Nature Medicine | 17 Jun 2019 | 991 |
| 17 | Reactome pathway analysis: a high-performance in-memory approach Antonio Fabregat, Konstantinos Sidiropoulos, Guilherme Viteri et al. · BMC Bioinformatics | Mar 2017 | 945 |
| 18 | Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms David Ezra Gordon et al. · Science | 15 Oct 2020 | 819 |
| 19 | Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics Maya Ghoussaini et al. · Nucleic Acids Research | 17 Sep 2020 | 717 |
| 20 | An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci Edward Mountjoy, Ellen M. Schmidt, Miguel Carmona et al. · Nature Genetics | 28 Oct 2021 | 658 |
| 21 | Fine-mapping inflammatory bowel disease loci to single-variant resolution Hailiang Huang et al. · Nature | 28 Jun 2017 | 653 |
| 22 | From GWAS to Function: Using Functional Genomics to Identify the Mechanisms Underlying Complex Diseases Eddie Cano-Gamez, Gosia Trynka · Frontiers in Genetics | 13 May 2020 | 635 |
| 23 | Open Targets Platform: supporting systematic drug–target identification and prioritisation David Ochoa et al. · Nucleic Acids Research | 11 Nov 2020 | 577 |
| 24 | Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer’s disease risk genes Jeremy Schwartzentruber, Sarah Cooper, Jimmy Z. Liu et al. · Nature Genetics | 15 Feb 2021 | 572 |
| 25 | Open Targets: a platform for therapeutic target identification and validation Gautier Koscielny et al. · Nucleic Acids Research | 3 Nov 2016 | 553 |
| 26 | Open Targets Platform: new developments and updates two years on Denise Carvalho‐Silva, Andrea Pierleoni, Miguel Pignatelli et al. · Nucleic Acids Research | 26 Oct 2018 | 537 |
| 27 | Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction David V. Conti et al. · Nature Genetics | 2021 | 511 |
| 28 | A compendium of uniformly processed human gene expression and splicing quantitative trait loci Nurlan Kerimov, James D. Hayhurst, Kateryna Peikova et al. · Nature Genetics | Sep 2021 | 489 |
| 29 | The next-generation Open Targets Platform: reimagined, redesigned, rebuilt David Ochoa et al. · Nucleic Acids Research | 27 Oct 2022 | 473 |
| 30 | The NHGRI-EBI GWAS Catalog: standards for reusability, sustainability and diversity María Cerezo et al. · Nucleic Acids Research | 22 Oct 2024 | 409 |
| 31 | Genetic predisposition to mosaic Y chromosome loss in blood Deborah J. Thompson et al. · Nature | 20 Nov 2019 | 361 |
| 32 | Integrated cross-study datasets of genetic dependencies in cancer Clare Pacini, Joshua M. Dempster, Isabella Boyle et al. · Nature Communications | 12 Mar 2021 | 348 |
| 33 | Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation Julie Jerber, Daniel D. Seaton, Anna S. E. Cuomo et al. · Nature Genetics | Mar 2021 | 346 |
| 34 | Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines Kiki Cano-Gamez, Blagoje Soskic, Theodoros I. Roumeliotis et al. · Nature Communications | 14 Apr 2020 | 314 |
| 35 | Reactome graph database: Efficient access to complex pathway data Antonio Fabregat, Florian Korninger, Guilherme Viteri et al. · PLoS Computational Biology | 29 Jan 2018 | 300 |
| 36 | Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets Joshua M. Dempster et al. · Nature Communications | 20 Dec 2019 | 287 |
| 37 | Human genetics evidence supports two-thirds of the 2021 FDA-approved drugs David Ochoa, Mohd Anisul Karim, Maya Ghoussaini et al. · Nature Reviews Drug Discovery | 8 Jul 2022 | 276 |
| 38 | The PROTACtable genome Melanie Schneider, Chris J. Radoux, Andrew Hercules et al. · Nature Reviews Drug Discovery | 20 Jul 2021 | 259 |
| 39 | IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes Yukihide Momozawa et al. · Nature Communications | 15 Jun 2018 | 256 |
| 40 | Gene expression variability across cells and species shapes innate immunity Tzachi Hagai et al. · Nature | 23 Oct 2018 | 255 |
| 41 | The single-cell eQTLGen consortium Monique G.P. van der Wijst, DH de Vries, Hilde E. Groot et al. · eLife | 9 Mar 2020 | 246 |
| 42 | Reactome diagram viewer: data structures and strategies to boost performance Antonio Fabregat, Konstantinos Sidiropoulos, Guilherme Viteri et al. · Bioinformatics | 22 Nov 2017 | 238 |
| 43 | A map of transcriptional heterogeneity and regulatory variation in human microglia Adam M. H. Young et al. · Nature Genetics | Jun 2021 | 237 |
| 44 | Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer Luz García‐Alonso, Francesco Iorio, Angela Matchan et al. · Cancer Research | 11 Dec 2017 | 237 |
| 45 | Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery Annalisa Buniello et al. · Nucleic Acids Research | 30 Oct 2024 | 214 |
| 46 | Single-cell and spatial transcriptomics analysis of non-small cell lung cancer Marco De Zuani, Haoliang Xue, Jun Sung Park et al. · Nature Communications | 23 May 2024 | 206 |
| 47 | Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation Blagoje Soskic, Kiki Cano-Gamez, Deborah J. Smyth et al. · Nature Genetics | 26 May 2022 | 191 |
| 48 | Reactome enhanced pathway visualization Konstantinos Sidiropoulos, Guilherme Viteri, Cristoffer Sevilla et al. · Bioinformatics | 5 Jul 2017 | 189 |
| 49 | The Gene Curation Coalition: A global effort to harmonize gene–disease evidence resources Marina T. DiStefano et al. · Genetics in Medicine | 4 May 2022 | 169 |
| 50 | A Novel, Macrophage Migration Inhibitory Factor Suicide Substrate Inhibits Motility and Growth of Lung Cancer Cells Millicent G. Winner, Jason B. Meier, Swen Zierow et al. · Cancer Research | 14 Sep 2008 | 168 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.