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Institution · System Biosciences (United States)

Most cited papers from System Biosciences (United States)

System Biosciences (United States)

What are the most cited papers from System Biosciences (United States)?

The most cited paper from System Biosciences (United States) is "Isolation of a candidate human hematopoietic stem-cell population." (Claire Baum, Irving L. Weissman, Atsushi Tsukamoto et al., 1992), with 1,098 citations. Next come "Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment" (872) and "Optimized Codon Usage and Chromophore Mutations Provide Enhanced Sensitivity with the Green Fluorescent Protein" (454).

Showing 50 of 60 papers. Every paper with more than 32 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Isolation of a candidate human hematopoietic stem-cell population. Claire Baum, Irving L. Weissman, Atsushi Tsukamoto et al. · Proceedings of the National Academy of Sciences Open access Apr 1992 1,098
2 Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment Vivian Barry-Hamilton et al. · Nature Medicine Sep 2010 872
3 Optimized Codon Usage and Chromophore Mutations Provide Enhanced Sensitivity with the Green Fluorescent Protein Ting Yang, Linzhao Cheng, Steven R. Kain · Nucleic Acids Research Open access Nov 1996 454
4 Negative regulation of lncRNA GAS5 by miR-21 Zhiren Zhang, Zhe Zhu, Kounosuke Watabe et al. · Cell Death and Differentiation Open access 9 Aug 2013 423
5 Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX–ENL Catherine Lavau, Stephen J. Szilvassy, Robert Slany et al. · The EMBO Journal Open access 15 Jul 1997 410
6 Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1) Jianguo Huang, Nanjiang Zhou, Kounosuke Watabe et al. · Cell Death and Disease Open access 23 Jan 2014 377
7 FDA Modernization Act 2.0: transitioning beyond animal models with human cells, organoids, and AI/ML-based approaches Peter-James H. Zushin, Souhrid Mukherjee, Joseph C. Wu · Journal of Clinical Investigation Open access 31 Oct 2023 339
8 Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping Stefanie L. Morgan, Natasha C. Mariano, Abel Cuevas Bermúdez et al. · Nature Communications Open access 13 Jul 2017 294
9 Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680 Matthew A. Young, Neil P. Shah, Luke H. Chao et al. · Cancer Research 15 Jan 2006 278
10 Targeting non-coding RNAs with the CRISPR/Cas9 system in human cell lines Tsui-Ting Ho, Nanjiang Zhou, Jianguo Huang et al. · Nucleic Acids Research Open access 20 Nov 2014 247
11 Identification of a MicroRNA Panel for Clear-cell Kidney Cancer David Juan, Gabriela Alexe, Travis J. Antes et al. · Urology 30 Dec 2009 225
12 Integrated systems for exosome investigation Maureen Peterson, Nicole Otoc, Jasmine K. Sethi et al. · Methods 26 Apr 2015 211
13 Enrichment of human hematopoietic stem cell activity in the CD34+Thy- 1+Lin- subpopulation from mobilized peripheral blood Lesley J. Murray, B Chen, Anne Galy et al. · Blood Open access 15 Jan 1995 207
14 Implantation and maintenance of functional human bone marrow in SCID-hu mice S Kyoizumi, CM Baum, H Kaneshima et al. · Blood Apr 1992 203
15 Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation Jing‐Hung Wang, Alexis V. Forterre, Jinjing Zhao et al. · Molecular Cancer Therapeutics Open access 26 Feb 2018 180
16 Monocyte exosomes induce adhesion molecules and cytokines via activation of NF‐κB in endothelial cells Norina Tang, Bing Sun, Archana Anshuman Gupta et al. · The FASEB Journal Open access 25 May 2016 176
17 Transplantation of highly purified CD34+Thy-1+ hematopoietic stem cells in patients with metastatic breast cancer Robert S. Negrin, Kerry Atkinson, Tom Leemhuis et al. · Transplantation and Cellular Therapy Open access May 2000 166
18 Two-year safety and clinical outcomes in chronic ischemic stroke patients after implantation of modified bone marrow–derived mesenchymal stem cells (SB623): a phase 1/2a study Gary Kenneth Steinberg, Douglas S Kondziolka, Lawrence R. Wechsler et al. · Journal of neurosurgery Open access 27 Feb 2019 156
19 Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II Rachael Elizabeth Hawtin, David E. Stockett, Jo Ann W. Byl et al. · PLoS ONE Open access 15 Apr 2010 150
20 Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis Ramesh Singh, Shrish C. Gupta, W-X Peng et al. · Cell Death and Disease Open access 9 Jun 2016 148
21 Overexpression of the p80 TNF Receptor Leads to TNF-Dependent Apoptosis, Nuclear Factor-κB Activation, and c-Jun Kinase Activation Valsala Haridas, Bryant G. Darnay, Kasthuri Natarajan et al. · The Journal of Immunology Apr 1998 137
22 Thrombopoietin stimulates megakaryocytopoiesis, myelopoiesis, and expansion of CD34+ progenitor cells from single CD34+Thy-1+Lin- primitive progenitor cells JC Young, Edward Bruno, KM Luens et al. · Blood Open access Sep 1996 130
23 Human T cells in the SCID-hu mouse are phenotypically normal and functionally competent John F. Krowka, Shiv Kumar Sarin, Reiko Namikawa et al. · The Journal of Immunology Jun 1991 123
24 LncRNA AK023948 is a positive regulator of AKT Pratirodh Koirala, Jianguo Huang, Tsui-Ting Ho et al. · Nature Communications Open access 8 Feb 2017 117
25 A GFP reporter system to assess gene transfer and expression in human hematopoietic progenitor cells Linzhao Cheng, Chang Jiang Du, David W. Murray et al. · Gene Therapy Oct 1997 117
26 Meditation and vacation effects have an impact on disease-associated molecular phenotypes Elissa S. Epel, Eli M. Puterman, Jue Lin et al. · Translational Psychiatry Open access 30 Aug 2016 109
27 Physiological enzymatic cleavage of leukocyte membrane molecules Vladimír Bažil · Immunology Today Open access Mar 1995 104
28 Antiretroviral Drugs Alter the Content of Extracellular Vesicles from HIV-1-Infected Cells Catherine DeMarino et al. · Scientific Reports Open access 10 May 2018 93
29 Primitive hematopoietic cells in murine bone marrow express the CD34 antigen Franck Morel, SJ Szilvassy, Marilyn A. Travis et al. · Blood Open access 15 Nov 1996 92
30 The Use of Human Mesenchymal Stem Cell–Derived Feeder Cells for the Cultivation of Transplantable Epithelial Sheets Masahiro Omoto, Hideyuki Miyashita, Shigeto Shimmura et al. · Investigative Ophthalmology & Visual Science 22 Apr 2009 89
31 Equal distribution of competitive long-term repopulating stem cells in the CD34+ and CD34- fractions of Thy-1lowLin-/lowSca-1+ bone marrow cells. Franck Morel, Anne Galy, B Chen et al. · PubMed May 1998 88
32 Industrial Enzymology: The Next Chapter Michael V. Arbige, Jay K. Shetty, GOPAL K. CHOTANI · Trends in biotechnology Review Nov 2019 83
33 Primitive human hematopoietic cells displaying differential efflux of the rhodamine 123 dye have distinct biological activities Naoshige Uchida, J Combs, Shujing Chen et al. · Blood 15 Aug 1996 81
34 Engraftment of human hematopoietic precursor cells with secondary transfer potential in SCID-hu mice BP Chen, Anne Galy, S Kyoizumi et al. · Blood 15 Oct 1994 79
35 Marrow-derived heparan sulfate proteoglycan mediates the adhesion of hematopoietic progenitor cells to cytokines. Edward Bruno, Sharon D. Luikart, Michael William Long et al. · PubMed Oct 1995 79
36 High-resolution structure of a lytic polysaccharide monooxygenase from Hypocrea jecorina reveals a predicted linker as an integral part of the catalytic domain Henrik Hansson, Saeid Karkehabadi, Nils Egil Mikkelsen et al. · Journal of Biological Chemistry Open access 12 Sep 2017 78
37 From stem cells to lymphocytes; biology and transplantation Hector Leonardo Aguila, Koichr Akashi, Jos Domen et al. · Immunological Reviews ReviewOpen access Jun 1997 70
38 Regulation of ABCG1 expression in human keratinocytes and murine epidermis Yan J. Jiang, Biao Lü, Elizabeth J. Tarling et al. · Journal of Lipid Research Open access 2 Aug 2010 69
39 Apoptosis of human hematopoietic progenitor cells induced by crosslinking of surface CD43, the major sialoglycoprotein of leukocytes Vladimír Bažil, J Brandt, Ann S. Tsukamoto et al. · Blood 15 Jul 1995 69
40 Regulation of androgen receptor splice variant AR3 by PCGEM1 Ziqiang Zhang, Nanjiang Zhou, Jianguo Huang et al. · Oncotarget Open access 2 Feb 2016 67
41 Regulation of miRNA expression by Src and contact normalization: effects on nonanchored cell growth and migration X Li, Yongquan Shen, Hitoshi Ichikawa et al. · Oncogene 21 Sep 2009 66
42 Stem cell-paved biobridge facilitates neural repair in traumatic brain injury Naoki Tajiri, Kelsey Duncan, Alesia Antoine et al. · Frontiers in Systems Neuroscience Open access 24 Jun 2014 63
43 Exosome mediated delivery of functional nucleic acid nanoparticles (NANPs) Senny Nordmeier, Weina Ke, Kirill A. Afonin et al. · Nanomedicine Nanotechnology Biology and Medicine Open access 8 Aug 2020 52
44 Partially differentiated ex vivo expanded cells accelerate hematologic recovery in myeloablated mice transplanted with highly enriched long- term repopulating stem cells SJ Szilvassy, KP Weller, B Chen et al. · Blood Nov 1996 52
45 Regulation of PCGEM1 by p54/nrb in prostate cancer Tsui-Ting Ho, Jianguo Huang, Nanjiang Zhou et al. · Scientific Reports Open access 29 Sep 2016 51
46 Receptor activity modifying protein‐3 mediates the protumorigenic activity of lysyl oxidase‐like protein‐2 Vera Brekhman, Jennie Lugassie, Shelly Zaffryar‐Eilot et al. · The FASEB Journal 27 Aug 2010 51
47 A monoclonal antibody recognizing CD43 (leukosialin) initiates apoptosis of human hematopoietic progenitor cells but not stem cells Vladimír Bažil, J Brandt, S Chen et al. · Blood 15 Feb 1996 47
48 Preclinical analysis of cytokine therapy in the SCID-hu mouse S Kyoizumi, LJ Murray, R Namikawa · Blood 15 Mar 1993 46
49 Ginkgo Biloba Extract Induces Gene Expression Changes in Xenobiotics Metabolism and the Myc-Centered Network Lei Guo, Nan Mei, Wayne C. Liao et al. · OMICS A Journal of Integrative Biology Open access Feb 2010 45
50 Fetal bone marrow CD34+CD41+ cells are enriched for multipotent hematopoietic progenitors, but not for pluripotent stem cells. L J Murray, Daniza Mandich, E Bruno et al. · PubMed Feb 1996 45

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.