| 1 |
Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance
Jaakko O. Tuomilehto, Jaana Lindström, Johan Gunnar Eriksson et al. · New England Journal of Medicine
Open access |
3 May 2001 |
10,985 |
| 2 |
2018 ESC/ESH Guidelines for the management of arterial hypertension
Bryan Williams et al. · European Heart Journal
Open access211 authors |
25 Aug 2018 |
10,602 |
| 3 |
The mutational constraint spectrum quantified from variation in 141,456 humans
Konrad J. Karczewski et al. · Nature
Open access177 authors |
27 May 2020 |
10,422 |
| 4 |
The art of case study research
Reijo Savolainen · Library & Information Science Research
|
Jun 1996 |
8,256 |
| 5 |
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J. Klionsky et al. · Autophagy
Open access2,467 authors |
2 Jan 2016 |
6,023 |
| 6 |
Cumulated gain-based evaluation of IR techniques
Kalervo Järvelin, Jaana Kekäläinen · ACM Transactions on Information Systems
|
Oct 2002 |
4,810 |
| 7 |
FinnGen provides genetic insights from a well-phenotyped isolated population
Mitja Kurki et al. · Nature
Open access169 authors |
18 Jan 2023 |
4,362 |
| 8 |
Tissue microarrays for high-throughput molecular profiling of tumor specimens
Juha Kononen, Lukas Bubendorf, Anne Kallionimeni et al. · Nature Medicine
|
Jul 1998 |
4,144 |
| 9 |
Screening and Prostate-Cancer Mortality in a Randomized European Study
Fritz H. Schröder et al. · New England Journal of Medicine
Open access |
18 Mar 2009 |
4,042 |
| 10 |
The repertoire of mutational signatures in human cancer
Ludmil B. Alexandrov et al. · Nature
Open access1,384 authors |
5 Feb 2020 |
3,854 |
| 11 |
Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies
Antonis C. Antoniou et al. · The American Journal of Human Genetics
Open access |
23 Apr 2003 |
3,727 |
| 12 |
Biological, clinical and population relevance of 95 loci for blood lipids
Tanya M. Teslovich et al. · Nature
Open access209 authors |
Aug 2010 |
3,706 |
| 13 |
OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis
Raveendhara R. Bannuru et al. · Osteoarthritis and Cartilage
Open access |
3 Jul 2019 |
3,686 |
| 14 |
Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology
Robert S. Fisher, Judith Helen Cross, Jacqueline A. French et al. · Epilepsia
Open access |
8 Mar 2017 |
3,494 |
| 15 |
Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer
Babak Ehteshami Bejnordi et al. · JAMA
Open access |
12 Dec 2017 |
3,405 |
| 16 |
Pan-cancer analysis of whole genomes
Lauri A. Aaltonen et al. · Nature
Open access1,324 authors |
5 Feb 2020 |
3,360 |
| 17 |
The sharing economy: Why people participate in collaborative consumption
Juho Hamari, Mimmi Sjöklint, Antti Ukkonen · Journal of the Association for Information Science and Technology
|
2 Jun 2015 |
3,320 |
| 18 |
Discovery and refinement of loci associated with lipid levels
Cristen J. Willer et al. · Nature Genetics
Open access259 authors |
6 Oct 2013 |
3,319 |
| 19 |
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
MAGIC et al. · Nature Genetics
Open access376 authors |
10 Oct 2010 |
2,999 |
| 20 |
Synaptic, transcriptional and chromatin genes disrupted in autism
The DDD Study et al. · Nature
Open access |
29 Oct 2014 |
2,993 |
| 21 |
Promoting ecosystem and human health in urban areas using Green Infrastructure: A literature review
Konstantinos Tzoulas, Kalevi Korpela, Stephen Venn et al. · Landscape and Urban Planning
Open access |
8 Mar 2007 |
2,837 |
| 22 |
1D convolutional neural networks and applications: A survey
Kiranyaz, Mustafa Serkan, Onur Avcı, Osama Abdeljaber et al. · Qatar University QSpace (Qatar University)
|
2021 |
2,836 |
| 23 |
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Aleksandra Trifunović, Anna Wredenberg, Maria Falkenberg et al. · Nature
|
May 2004 |
2,779 |
| 24 |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
Stephen J. Sawcer et al. · Nature
Open access241 authors |
Aug 2011 |
2,772 |
| 25 |
A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
Majid Nikpay et al. · Nature Genetics
ReviewOpen access151 authors |
7 Sep 2015 |
2,733 |
| 26 |
European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease
Steffen Husby, Sibylle Koletzko, Ilma Rita Korponay-Szabo et al. · Journal of Pediatric Gastroenterology and Nutrition
Open access |
4 Oct 2011 |
2,706 |
| 27 |
Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017
Christina Fitzmaurice et al. · JAMA Oncology
Open access628 authors |
27 Sep 2019 |
2,699 |
| 28 |
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Céline Bellenguez et al. · Nature Genetics
Open access1,266 authors |
Apr 2022 |
2,608 |
| 29 |
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
Urmo Võsa et al. · Nature Genetics
Open access114 authors |
Sep 2021 |
2,339 |
| 30 |
Electronic structure calculations with GPAW: a real-space implementation of the projector augmented-wave method
Jussi Enkovaara et al. · Journal of Physics Condensed Matter
Open access |
10 Jun 2010 |
2,332 |
| 31 |
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
Evanna L. Mills, Beth L. Kelly, Angela Logan et al. · Cell
Open access |
22 Sep 2016 |
2,314 |
| 32 |
European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2020 Guidelines
Johannes Alfred Witjes, Harman Max Bruins, Richard L. Cathomas et al. · European Urology
|
29 Apr 2020 |
2,175 |
| 33 |
Temporal development of the gut microbiome in early childhood from the TEDDY study
Christopher J. Stewart et al. · Nature
Open access |
Oct 2018 |
2,147 |
| 34 |
Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial
Sanjit S. Jolly, Salim Yusuf, John A. Cairns et al. · The Lancet
|
Apr 2011 |
2,130 |
| 35 |
Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
Adrian R. Martineau et al. · BMJ
ReviewOpen access |
15 Feb 2017 |
2,088 |
| 36 |
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Georg Ehret et al. · Nature
Open access346 authors |
9 Sep 2011 |
2,085 |
| 37 |
Hundreds of variants clustered in genomic loci and biological pathways affect human height
Hana Lango Allen et al. · Nature
Open access293 authors |
29 Sep 2010 |
2,063 |
| 38 |
Analysis of shared heritability in common disorders of the brain
Verneri Anttila et al. · Science
Open access577 authors |
21 Jun 2018 |
2,056 |
| 39 |
Digital control of dynamic systems
Heikki N. Koivo · Automatica
|
Jul 1983 |
1,964 |
| 40 |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Cardiogenics et al. · Nature Genetics
Open access167 authors |
6 Mar 2011 |
1,959 |
| 41 |
The 2020 report of The Lancet Countdown on health and climate change: responding to converging crises
Nick Watts et al. · The Lancet
Open access |
2 Dec 2020 |
1,949 |
| 42 |
Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study
Elina Hyppönen, Esa Läärä, Antti Reunanen et al. · The Lancet
|
Nov 2001 |
1,941 |
| 43 |
Safety and Efficacy of a Pentavalent Human–Bovine (WC3) Reassortant Rotavirus Vaccine
Timo Vesikari et al. · New England Journal of Medicine
Open access |
4 Jan 2006 |
1,890 |
| 44 |
Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies
Sarah C. Darby et al. · BMJ
Open access |
21 Dec 2004 |
1,832 |
| 45 |
Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study
Jaana Lindström, Pirjo Ilanne‐Parikka, Markku Peltonen et al. · The Lancet
|
Nov 2006 |
1,819 |
| 46 |
Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up
Andrés Cervantes, R. Adam, Susana Roselló et al. · Annals of Oncology
Open access |
25 Oct 2022 |
1,794 |
| 47 |
The rise of motivational information systems: A review of gamification research
Jonna Koivisto, Juho Hamari · International Journal of Information Management
Open access |
10 Dec 2018 |
1,735 |
| 48 |
Cardiovascular Risk Factors in Childhood and Carotid Artery Intima-Media Thickness in Adulthood
Olli Tuomas Raitakari, Markus Juonala, Mika A. P. Kähönen et al. · JAMA
Open access |
4 Nov 2003 |
1,734 |
| 49 |
The Oslo definitions for coeliac disease and related terms
Jonas Filip Ludvigsson, Daniel A. Leffler, Julio C. Bai et al. · Gut
Open access |
16 Feb 2012 |
1,730 |
| 50 |
Challenging games help students learn: An empirical study on engagement, flow and immersion in game-based learning
Juho Hamari, David J. Shernoff, Elizabeth Ashman Rowe et al. · Computers in Human Behavior
Open access |
15 Aug 2015 |
1,703 |