Topic · Cancer, Hypoxia, and Metabolism
Most cited papers in Cancer, Hypoxia, and Metabolism
What are the most cited papers in Cancer, Hypoxia, and Metabolism?
The most cited paper in Cancer, Hypoxia, and Metabolism is "Hallmarks of Cancer: The Next Generation" (Douglas Hanahan, Robert A. Weinberg, 2011), with 67,836 citations. Next come "Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation" (16,511) and "The biology of VEGF and its receptors" (9,633).
Showing 50 of 100 papers. Every paper with more than 2,289 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Hallmarks of Cancer: The Next Generation Douglas Hanahan, Robert A. Weinberg · Cell | Mar 2011 | 67,836 |
| 2 | Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation Matthew G. Vander Heiden, Lewis C. Cantley, Craig B. Thompson · Science | 21 May 2009 | 16,511 |
| 3 | The biology of VEGF and its receptors Napoleone Ferrara, Hans‐Peter Gerber, Jennifer E. LeCouter · Nature Medicine | 30 May 2003 | 9,633 |
| 4 | Angiogenesis in cancer and other diseases Peter Carmeliet, Rakesh K. Jain · Nature | Sep 2000 | 9,128 |
| 5 | Isolation of Putative Progenitor Endothelial Cells for Angiogenesis Takayuki Asahara, Toyoaki Murohara, Alison B. Sullivan et al. · Science | 14 Feb 1997 | 8,789 |
| 6 | Microenvironmental regulation of tumor progression and metastasis Daniela F. Quail, Johanna A. Joyce · Nature Medicine | Nov 2013 | 8,290 |
| 7 | Angiogenesis in cancer, vascular, rheumatoid and other disease Judah Folkman · Nature Medicine | 1995 | 7,691 |
| 8 | A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Yasuhiro Matsumura, Hiroshi Maeda · PubMed | Dec 1986 | 6,800 |
| 9 | Photodynamic therapy for cancer Dennis E. J. G. J. Dolmans, Dai Fukumura, Rakesh K. Jain · Nature reviews. Cancer | May 2003 | 6,780 |
| 10 | Targeting HIF-1 for cancer therapy Gregg L. Semenza · Nature reviews. Cancer | 16 Sep 2003 | 6,772 |
| 11 | Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review Hiroshi Maeda, Jun Wu, Tomohiro Sawa et al. · Journal of Controlled Release | Mar 2000 | 6,577 |
| 12 | Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences | 6 Jun 1995 | 6,278 |
| 13 | The Emerging Hallmarks of Cancer Metabolism Natalya N. Pavlova, Craig B. Thompson · Cell Metabolism | 2016 | 6,192 |
| 14 | Mechanisms of angiogenesis Werner Risau · Nature | Apr 1997 | 5,752 |
| 15 | Stable Isotope Labeling by Amino Acids in Cell Culture, SILAC, as a Simple and Accurate Approach to Expression Proteomics Shao‐En Ong, Blagoy Blagoev, Irina Kratchmarova et al. · Molecular & Cellular Proteomics | May 2002 | 5,654 |
| 16 | Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation Panu Jaakkola, David Robert Mole, Ya‐Min Tian et al. · Science | 20 Apr 2001 | 5,570 |
| 17 | Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy Rakesh K. Jain · Science | 6 Jan 2005 | 5,534 |
| 18 | Molecular mechanisms and clinical applications of angiogenesis Peter Carmeliet, Rakesh K. Jain · Nature | May 2011 | 5,504 |
| 19 | The Warburg Effect: How Does it Benefit Cancer Cells? Maria V. Liberti, Jason W. Locasale · Trends in Biochemical Sciences | 5 Jan 2016 | 5,355 |
| 20 | The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis Patrick Henry Maxwell, Michael Sean Wiesener, Gin-Wen Chang et al. · Nature | May 1999 | 5,248 |
| 21 | Hypoxia — a key regulatory factor in tumour growth Adrian L. Harris · Nature reviews. Cancer | 2002 | 5,228 |
| 22 | Photodynamic therapy of cancer: An update Patrizia Agostinis, Kristian Berg, Keith A. Cengel et al. · CA A Cancer Journal for Clinicians | 26 May 2011 | 5,169 |
| 23 | A Perspective on Cancer Cell Metastasis Christine Louise Chaffer, Robert A. Weinberg · Science | 24 Mar 2011 | 4,934 |
| 24 | Why do cancers have high aerobic glycolysis? Robert A. Gatenby, Robert J. Gillies · Nature reviews. Cancer | Nov 2004 | 4,841 |
| 25 | Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients Francesco Locatelli, Steven N. Fishbane, Geoffrey A. Block et al. · American Journal of Nephrology | 2017 | 4,818 |
| 26 | Regulation of cancer cell metabolism Rob A. Cairns, Isaac S. Harris, Tak W. Mak · Nature reviews. Cancer | 24 Jan 2011 | 4,811 |
| 27 | Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment Douglas Hanahan, Lisa M. Coussens · Cancer Cell | Mar 2012 | 4,765 |
| 28 | HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science | 20 Apr 2001 | 4,757 |
| 29 | Photodynamic Therapy Thomas J. Dougherty, Charles J. Gomer, Barbara W. Henderson et al. · JNCI Journal of the National Cancer Institute | 17 Jun 1998 | 4,711 |
| 30 | Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis Dorit Shweiki, Ahuva Itin, Dov Soffer et al. · Nature | Oct 1992 | 4,656 |
| 31 | Fibroblasts in cancer Raghu K. Kalluri, Michael Zeisberg · Nature reviews. Cancer | 30 Mar 2006 | 4,547 |
| 32 | Microtubules as a target for anticancer drugs Mary Ann Jordan, Leslie Wilson · Nature reviews. Cancer | Apr 2004 | 4,546 |
| 33 | Metabolic regulation of gene expression by histone lactylation Di Zhang et al. · Nature | 23 Oct 2019 | 4,352 |
| 34 | Cancer-associated IDH1 mutations produce 2-hydroxyglutarate Lenny Dang, David W. White, Stefan Größ et al. · Nature | 22 Nov 2009 | 4,209 |
| 35 | Mechanisms of angiogenesis and arteriogenesis Peter Carmeliet · Nature Medicine | Apr 2000 | 4,189 |
| 36 | The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation Ralph J. DeBerardinis, Julian J. Lum, Georgia Hatzivassiliou et al. · Cell Metabolism | 2008 | 4,188 |
| 37 | Amino Acid Metabolism in Mammalian Cell Cultures Harry Eagle · Science | 21 Aug 1959 | 4,032 |
| 38 | Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1 Jo A. Forsythe, Bing‐Hua Jiang, Narayan V. Iyer et al. · Molecular and Cellular Biology | Sep 1996 | 4,003 |
| 39 | HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia Jung‐whan Kim, Irina Tchernyshyov, Gregg L. Semenza et al. · Cell Metabolism | Mar 2006 | 3,976 |
| 40 | Angiogenic Factors Judah Folkman, Michael Klagsbrun · Science | 23 Jan 1987 | 3,784 |
| 41 | Vascular Endothelial Growth Factor: Basic Science and Clinical Progress Napoleone Ferrara · Endocrine Reviews | Aug 2004 | 3,722 |
| 42 | Vascular-specific growth factors and blood vessel formation George D. Yancopoulos, Samuel H. Davis, Nicholas W. Gale et al. · Nature | Sep 2000 | 3,706 |
| 43 | JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA Marilyn G. Farquhar, George E. Palade · The Journal of Cell Biology | May 1963 | 3,654 |
| 44 | Hypoxia-Inducible Factors in Physiology and Medicine Gregg L. Semenza · Cell | Feb 2012 | 3,632 |
| 45 | Modulation of oxidative stress as an anticancer strategy Chiara Gorrini, Isaac S. Harris, Tak W. Mak · Nature Reviews Drug Discovery | 29 Nov 2013 | 3,620 |
| 46 | Tumorigenesis and the angiogenic switch Gabriele Bergers, Laura E. Benjamin · Nature reviews. Cancer | 30 May 2003 | 3,553 |
| 47 | Vascular endothelial growth factor (VEGF) and its receptors Gera Neufeld, Tzafra Cohen, Stela Gengrinovitch et al. · The FASEB Journal | 1999 | 3,520 |
| 48 | Otto Warburg's contributions to current concepts of cancer metabolism Willem Hendrik Koppenol, Patricia L. Bounds, Chi V. Dang · Nature reviews. Cancer | 14 Apr 2011 | 3,514 |
| 49 | Angiogenesis in life, disease and medicine Peter Carmeliet · Nature | Dec 2005 | 3,495 |
| 50 | Reactive oxygen species in cancer Geou‐Yarh Liou, Peter Störz · Free Radical Research | 2010 | 3,440 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.