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Topic · Cancer Research

Cancer, Hypoxia, and Metabolism

Cancer, Hypoxia, and Metabolism is a research topic within Cancer Research. Science Explorer counts 79k research works in it since 1950. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the metabolic reprogramming in cancer cells, focusing on the role of hypoxia-inducible factor 1 (HIF-1), the Warburg effect, tumor hypoxia, glutamine metabolism, and the impact of the tumor microenvironment on cancer cell metabolism. It also delves into oxygen sensing, mitochondrial metabolism, glycolysis inhibition, and the role of hexokinase II in cancer progression.

  • HIF-1
  • Warburg Effect
  • Tumor Hypoxia
  • Cancer Cell Metabolism
  • Glutamine Metabolism
  • Oxygen Sensing
  • Mitochondrial Metabolism
  • Glycolysis Inhibition
  • Tumor Microenvironment
  • Hexokinase II
Research works
79k
fractional, since 1950
In the world top 10%
8k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+9%
the tick is no change
Largest producer
China
47% of the 10 largest, 2022-now
Cancer, Hypoxia, and Metabolism

Which countries lead Cancer, Hypoxia, and Metabolism research?

By volume, China and the United States publish the most (5.5k and 3.2k works in 2022-now).

By volume, 2022-now

  1. 1 China 5.5k works
  2. 2 United States 3.2k works
  3. 3 Japan 584 works
  4. 4 India 580 works
  5. 5 Germany 417 works
  6. 6 Italy 383 works
  7. 7 United Kingdom 348 works
  8. 8 South Korea 346 works
  9. 9 France 251 works
  10. 10 Canada 226 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 46.8%United States: 26.7%Japan: 4.9%India: 4.9%6 others listed: 16.7%47%largest
China5,529 · 46.8%United States3,157 · 26.7%Japan584 · 4.9%India580 · 4.9%6 others listed1,972 · 16.7%

Shares of the rows listed above, not of the whole node.

Which institutions lead Cancer, Hypoxia, and Metabolism research?

By volume in 2022-now, Sun Yat-sen University publishes the most Cancer, Hypoxia, and Metabolism research, followed by Shanghai Jiao Tong University and Harvard University.

By volume, 2022-now

  1. 1 Sun Yat-sen UniversityChina 160 works
  2. 2 Shanghai Jiao Tong UniversityChina 144 works
  3. 3 Harvard UniversityUnited States 122 works
  4. 4 Nanjing Medical UniversityChina 116 works
  5. 5 Fudan UniversityChina 110 works
  6. 6 Sichuan UniversityChina 109 works
  7. 7 Zhejiang UniversityChina 104 works
  8. 8 Chinese Academy of SciencesChina 97 works
  9. 9 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 91 works
  10. 10 Huazhong University of Science and TechnologyChina 91 works

Who are the leading researchers in Cancer, Hypoxia, and Metabolism?

The most-cited researchers publishing on Cancer, Hypoxia, and Metabolism include Eric S. Lander, George Davey Smith and Stacey L. Gabriel.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 George Davey Smith United Kingdom 435k citations
  3. 3 Stacey L. Gabriel United States 402k citations
  4. 4 Peer Bork Germany 396k citations
  5. 5 Robert John Tibshirani United States 396k citations
  6. 6 Guido Kroemer France 386k citations
  7. 7 Bert Vogelstein United States 373k citations
  8. 8 Gad A. Getz United States 364k citations
  9. 9 Jost Bruno Jonas Germany 350k citations
  10. 10 Elaine R. Mardis United States 346k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Cancer, Hypoxia, and Metabolism?

The most cited paper in Cancer, Hypoxia, and Metabolism is "Hallmarks of Cancer: The Next Generation" (Douglas Hanahan, Robert A. Weinberg, 2011), with 67,836 citations. Next come "Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation" (16,511) and "The biology of VEGF and its receptors" (9,633).

Most cited papers
#PaperReleasedCitations
1 Hallmarks of Cancer: The Next Generation Douglas Hanahan, Robert A. Weinberg · Cell Open access Mar 2011 67,836
2 Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation Matthew G. Vander Heiden, Lewis C. Cantley, Craig B. Thompson · Science Open access 21 May 2009 16,511
3 The biology of VEGF and its receptors Napoleone Ferrara, Hans‐Peter Gerber, Jennifer E. LeCouter · Nature Medicine 30 May 2003 9,633
4 Angiogenesis in cancer and other diseases Peter Carmeliet, Rakesh K. Jain · Nature Sep 2000 9,128
5 Isolation of Putative Progenitor Endothelial Cells for Angiogenesis Takayuki Asahara, Toyoaki Murohara, Alison B. Sullivan et al. · Science 14 Feb 1997 8,789
All 100 most cited papers, with filters and sorting

Where is Cancer, Hypoxia, and Metabolism research done?

The largest centres of Cancer, Hypoxia, and Metabolism research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Nanjing (China). Among places with at least 20 works in it, it is an unusually large share of all research in Luzhou, Zunyi and Shatin.

Largest cities, 2022-now

  1. 1 BeijingChina 567 works
  2. 2 ShanghaiChina 502 works
  3. 3 GuangzhouChina 372 works
  4. 4 NanjingChina 260 works
  5. 5 WuhanChina 219 works
  6. 6 HangzhouChina 219 works
  7. 7 ChengduChina 169 works
  8. 8 ChongqingChina 161 works
  9. 9 SeoulSouth Korea 161 works
  10. 10 JinanChina 148 works

Where it is the local speciality

  1. LuzhouCN · 32.3 works9.1×
  2. ZunyiCN · 24.1 works8.1×
  3. ShatinCN · 23.2 works7.2×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Cancer, Hypoxia, and Metabolism than the world average.

See Cancer, Hypoxia, and Metabolism on the map

Where is the best place to study Cancer, Hypoxia, and Metabolism?

Among universities, judged by research, Harvard University, Sun Yat-sen University and Sichuan University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 15.41%fractional works in this field (log) →share of work in the world top 10% →Sichuan UniversityHarvard UniversityShanghai Jiao Tong U…Sun Yat-sen University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 74.616.0%3.1×122 -7.5%
2Sun Yat-sen UniversityChina 69.614.0%6.2×160 +23.2%
3Sichuan UniversityChina 66.717.4%3.9×109 +24.6%
4Shanghai Jiao Tong UniversityChina 65.815.2%4.0×144 +14.1%
5Fudan UniversityChina 65.414.8%5.6×110 +16.9%
6Zhejiang UniversityChina 65.015.9%3.1×104 +13.3%
7Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 65.016.4%6.9×91 +44.4%
8Nanjing Medical UniversityChina 64.812.9%10.4×116 +42.6%
9Huazhong University of Science and TechnologyChina 63.016.9%4.0×91 +33.4%
10University of Hong KongChina 63.014.6%2.7×32 +23.2%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Cancer, Hypoxia, and Metabolism, country by country

Is Cancer, Hypoxia, and Metabolism research growing?

Output in 2022-2025 was 9% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Cancer, Hypoxia, and Metabolism.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Cancer, Hypoxia, and Metabolism as a percentage of every work published that year, 0.059% in 2024.

still counting0.050%0.10%Cancer, Hypoxia, and Metabolism0.061% in 202519801990200020102020

Fractional works of Cancer, Hypoxia, and Metabolism over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Cancer, Hypoxia, and Metabolism9.6% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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