Synthesis and Biological Activity
Synthesis and Biological Activity is a research topic within Cancer Research. Science Explorer counts 8.3k research works in it since 1950. 10.6% of them reached the world's top 10% most cited for their field and year.
This cluster of papers focuses on the chemistry, biology, and synthesis of antitumor antibiotics, particularly tetrahydroisoquinoline compounds such as Ecteinascidin. It covers topics such as total synthesis, marine-derived compounds, asymmetric synthesis, and DNA binding mechanisms. The research also explores the pharmacological activities and potential clinical utility of these compounds.
- Tetrahydroisoquinoline
- Ecteinascidin
- Total Synthesis
- Anticancer Drug
- Marine-derived Compound
- Cycloaddition Reactions
- Asymmetric Synthesis
- Isocoumarins
- Pharmacology
- DNA Binding
- Research works
- 8.3k fractional, since 1950
- In the world top 10%
- 885 per year above
- Top-10% rate
- 10.6% share of its works in the world top 10%
- Growth, 2013–17 → 2018–22
- -32% the tick is no change
Which countries lead Synthesis and Biological Activity research?
By volume, China and India publish the most (168 and 79 works in 2022–2025).
By volume, 2022–2025
- 1 China 168 works
- 2 India 79 works
- 3 United States 34 works
- 4 Russia 27 works
- 5 Japan 22 works
- 6 Egypt 14 works
- 7 Indonesia 13 works
- 8 South Korea 13 works
- 9 Germany 12 works
- 10 Saudi Arabia 11 works
How concentrated that is
The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.
Shares of the rows listed above, not of the whole node.
Which institutions lead Synthesis and Biological Activity research?
By volume in 2022–2025, Chinese Academy of Sciences publishes the most Synthesis and Biological Activity research, followed by Academy of Scientific and Innovative Research and Chinese Academy of Medical Sciences & Peking Union Medical College.
By volume, 2022–2025
- 1 Chinese Academy of Sciences China 3 works
- 2 Academy of Scientific and Innovative Research India 3 works
- 3 Chinese Academy of Medical Sciences & Peking Union Medical College China 3 works
- 4 Sichuan University China 3 works
- 5 Jinan University China 3 works
- 6 Ocean University of China China 3 works
- 7 Chulalongkorn University Thailand 2 works
- 8 Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences Russia 2 works
- 9 Ufa Institute of Chemistry Russia 2 works
- 10 Lovely Professional University India 2 works
Who are the leading researchers in Synthesis and Biological Activity?
The most-cited researchers publishing on Synthesis and Biological Activity include Barry M. Trost, Carl Djerassi and Jon Clardy.
- 1 Barry M. Trost 3.8k citations
- 2 Carl Djerassi 1.9k citations
- 3 Jon Clardy 1.5k citations
- 4 Samuel J. Danishefsky 1.5k citations
Ranked by citations received across their whole record, among researchers with at least three works on this topic.
Where is Synthesis and Biological Activity research done?
The largest centres of Synthesis and Biological Activity research in 2022–2025 are Beijing (China), Shanghai (China), Guangzhou (China) and Tokyo (Japan).
Is Synthesis and Biological Activity research growing?
Output in 2018–2022 was 32% lower than in 2013–2017, peaking in 2014.
The same series as a ribbon — one cell per year, darker for more. The line above answers how much; this answers when.
Which topics inside it are moving
Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.