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Topic · Cancer Research

MicroRNA in disease regulation

MicroRNA in disease regulation is a research topic within Cancer Research. Science Explorer counts 66k research works in it since 1951. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the role of microRNAs in gene expression regulation, particularly in the context of cancer development and progression. It covers topics such as microRNA biogenesis, targeting specificity, biomarker potential, and therapeutic applications in cancer treatment.

  • MicroRNA
  • Gene Expression
  • Cancer
  • Regulation
  • Biomarkers
  • Biogenesis
  • Targeting
  • Therapeutics
  • Metastasis
  • Dysregulation
Research works
66k
fractional, since 1951
In the world top 10%
6.5k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-16%
the tick is no change
Largest producer
China
60% of the 10 largest, 2022-now
MicroRNA in disease regulation

Which countries lead MicroRNA in disease regulation research?

By volume, China and the United States publish the most (8.4k and 1.9k works in 2022-now).

By volume, 2022-now

  1. 1 China 8.4k works
  2. 2 United States 1.9k works
  3. 3 India 786 works
  4. 4 Iran 761 works
  5. 5 Italy 470 works
  6. 6 Japan 360 works
  7. 7 Germany 352 works
  8. 8 South Korea 326 works
  9. 9 Egypt 284 works
  10. 10 Spain 272 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 60.3%United States: 13.8%India: 5.6%Iran: 5.5%6 others listed: 14.8%60%largest
China8,417 · 60.3%United States1,923 · 13.8%India786 · 5.6%Iran761 · 5.5%6 others listed2,064 · 14.8%

Shares of the rows listed above, not of the whole node.

Which institutions lead MicroRNA in disease regulation research?

By volume in 2022-now, Nanjing Medical University publishes the most MicroRNA in disease regulation research, followed by Shanghai Jiao Tong University and Central South University.

By volume, 2022-now

  1. 1 Nanjing Medical UniversityChina 176 works
  2. 2 Shanghai Jiao Tong UniversityChina 169 works
  3. 3 Central South UniversityChina 162 works
  4. 4 Sun Yat-sen UniversityChina 158 works
  5. 5 Zhejiang UniversityChina 131 works
  6. 6 Sichuan UniversityChina 126 works
  7. 7 Harbin Medical UniversityChina 112 works
  8. 8 Chinese Academy of SciencesChina 112 works
  9. 9 Fudan UniversityChina 111 works
  10. 10 Wuhan UniversityChina 110 works

Who are the leading researchers in MicroRNA in disease regulation?

The most-cited researchers publishing on MicroRNA in disease regulation include Eric S. Lander, Zhong Lin Wang and Rob Knight.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 Zhong Lin Wang United States 491k citations
  3. 3 Rob Knight United States 468k citations
  4. 4 Stacey L. Gabriel United States 402k citations
  5. 5 Peer Bork Germany 396k citations
  6. 6 Robert John Tibshirani United States 396k citations
  7. 7 Guido Kroemer France 386k citations
  8. 8 Gad A. Getz United States 364k citations
  9. 9 Elaine R. Mardis United States 346k citations
  10. 10 Hermann Brenner Germany 343k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in MicroRNA in disease regulation?

The most cited paper in MicroRNA in disease regulation is "MicroRNAs: Target Recognition and Regulatory Functions" (David P. Bartel, 2009), with 20,551 citations. Next come "Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets" (12,048) and "Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines" (11,535).

Most cited papers
#PaperReleasedCitations
1 MicroRNAs: Target Recognition and Regulatory Functions David P. Bartel · Cell Open access 2009 20,551
2 Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets Benjamin P. Lewis, Christopher B. Burge, David P. Bartel · Cell Open access 2005 12,048
3 Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines Clotilde Théry et al. · Journal of Extracellular Vesicles Open access382 authors 23 Nov 2018 11,535
4 The biology , function , and biomedical applications of exosomes Raghu K. Kalluri, Valerie S. LeBleu · Science Open access 6 Feb 2020 10,939
5 The functions of animal microRNAs Victor Ambros · Nature Sep 2004 10,912
All 100 most cited papers, with filters and sorting

Where is MicroRNA in disease regulation research done?

The largest centres of MicroRNA in disease regulation research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Wuhan (China). Among places with at least 20 works in it, it is an unusually large share of all research in Baise City, Nantong and Zunyi.

Largest cities, 2022-now

  1. 1 BeijingChina 636 works
  2. 2 ShanghaiChina 572 works
  3. 3 GuangzhouChina 496 works
  4. 4 WuhanChina 347 works
  5. 5 NanjingChina 340 works
  6. 6 TehranIran 310 works
  7. 7 ChangshaChina 295 works
  8. 8 HangzhouChina 275 works
  9. 9 Xi'anChina 236 works
  10. 10 ChengduChina 229 works

Where it is the local speciality

  1. Baise CityCN · 21.6 works17×
  2. NantongCN · 92.9 works12×
  3. ZunyiCN · 36.3 works10×
← less than its size predicts1×more →

Location quotient: how much more of its research is in MicroRNA in disease regulation than the world average.

See MicroRNA in disease regulation on the map

Where is the best place to study MicroRNA in disease regulation?

Among universities, judged by research, Sichuan University, Al-Azhar University and Harvard University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 18.1%fractional works in this field (log) →share of work in the world top 10% →Al-Azhar UniversityHarvard UniversitySichuan UniversitySun Yat-sen University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Sichuan UniversityChina 66.718.1%3.8×126 +4.1%
2Al-Azhar UniversityEgypt 66.628.1%2.6×15 +59.3%
3Harvard UniversityUnited States 65.419.2%1.8×84 -22.2%
4Sun Yat-sen UniversityChina 63.516.3%5.1×158 -39.0%
5Shanghai Jiao Tong UniversityChina 63.016.1%4.0×169 -36.5%
6Central South UniversityChina 58.612.8%5.7×162 -33.6%
7Chengdu University of Traditional Chinese MedicineChina 57.916.2%7.8×30 +57.2%
8Southern Medical UniversityChina 57.415.9%10.6×97 -30.9%
9China Pharmaceutical UniversityChina 57.425.3%5.2×17 +4.8%
10Zhejiang UniversityChina 56.413.0%3.3×130 -30.9%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in MicroRNA in disease regulation, country by country

Is MicroRNA in disease regulation research growing?

Output in 2022-2025 was 16% lower than in 2018-2021, peaking in 2020.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is MicroRNA in disease regulation as a percentage of every work published that year, 0.072% in 2024.

still counting0.050%0.10%0.15%MicroRNA in disease regulation0.062% in 202519801990200020102020

Fractional works of MicroRNA in disease regulation over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%MicroRNA in disease regulation9.8% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Discussion

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