Topic · GDF15 and Related Biomarkers
Most cited papers in GDF15 and Related Biomarkers
What are the most cited papers in GDF15 and Related Biomarkers?
The most cited paper in GDF15 and Related Biomarkers is "Alzheimer's Disease: The Amyloid Cascade Hypothesis" (John Hardy, Gerald A. Higgins, 1992), with 7,581 citations. Next come "Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member" (4,036) and "Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure" (2,605).
Showing 50 of 99 papers. Every paper with more than 445 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Alzheimer's Disease: The Amyloid Cascade Hypothesis John Hardy, Gerald A. Higgins · Science | 10 Apr 1992 | 7,581 |
| 2 | Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member Alexandra C. McPherron, Ann M. Lawler, Se‐Jin Lee · Nature | May 1997 | 4,036 |
| 3 | Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure Beth Levine, Jill Kalman, Lloyd F. Mayer et al. · New England Journal of Medicine | 26 Jul 1990 | 2,605 |
| 4 | Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans Coleen Tara Murphy, Steven A. McCarroll, Cornelia I. Bargmann et al. · Nature | 29 Jun 2003 | 2,327 |
| 5 | The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis Masayuki P. Yamamoto, Thomas W. Kensler, Hozumi Motohashi · Physiological Reviews | 2 May 2018 | 1,982 |
| 6 | Cancer-associated cachexia Vickie Elaine Baracos, Lisa Warsinger Martin, Murray Korc et al. · Nature Reviews Disease Primers | 18 Jan 2018 | 1,759 |
| 7 | A proteomic atlas of senescence-associated secretomes for aging biomarker development Nathan Basisty, Abhijit Kale, Ok Hee Jeon et al. · PLoS Biology | 16 Jan 2020 | 1,369 |
| 8 | Biomarkers in Heart Failure Eugene Braunwald · New England Journal of Medicine | 14 May 2008 | 1,264 |
| 9 | Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay Nikki L. Parker, Mary Jo Turk, Elaine M. Westrick et al. · Analytical Biochemistry | 27 Jan 2005 | 1,198 |
| 10 | MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily Michelle R. Bootcov, Asne R. Bauskin, Stella M. Valenzuela et al. · Proceedings of the National Academy of Sciences | 14 Oct 1997 | 1,188 |
| 11 | Genetic associations with human longevity at the APOE and ACE loci François Schächter, Laurence Faure-Delanef, Frédérique Guénot et al. · Nature Genetics | 1994 | 1,102 |
| 12 | Role of homocysteine in the development of cardiovascular disease Paul K. Ganguly, Sreyoshi Fatima Alam · Nutrition Journal | 10 Jan 2015 | 1,059 |
| 13 | Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury Sang‐Bing Ong, Sapna Subrayan, Shiang Yong Lim et al. · Circulation | 26 Apr 2010 | 981 |
| 14 | Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease Gráinne S. Gorman, Andrew M. Schaefer, Yi Shiau Ng et al. · Annals of Neurology | 5 Feb 2015 | 974 |
| 15 | Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy Francesco S. Loffredo, Matthew L. Steinhauser, Steven M. Jay et al. · Cell | May 2013 | 965 |
| 16 | Understanding the mechanisms and treatment options in cancer cachexia Kenneth C. H. Fearon, Jann Arends, Vickie Elaine Baracos · Nature Reviews Clinical Oncology | 4 Dec 2012 | 962 |
| 17 | Sarcopenia John Edward Morley, Richard Baumgartner, Ronenn Roubenoff et al. · Journal of Laboratory and Clinical Medicine | Apr 2001 | 943 |
| 18 | Biomarkers: Potential uses and limitations Richard P Mayeux · NeuroRx | 30 Mar 2004 | 934 |
| 19 | Cytokine patterns in patients with cancer: a systematic review Bodo E. Lippitz · The Lancet Oncology | 29 Apr 2013 | 929 |
| 20 | Use of Multiple Biomarkers to Improve the Prediction of Death from Cardiovascular Causes Björn Zethelius, Lars Berglund, Johan Sundström et al. · New England Journal of Medicine | 14 May 2008 | 917 |
| 21 | Myostatin Inhibits Myoblast Differentiation by Down-regulating MyoD Expression Brett C. Langley, Mark Robert Thomas, Amy Bishop et al. · Journal of Biological Chemistry | Dec 2002 | 910 |
| 22 | Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice Orly Lazarov, John K. Robinson, Ya‐Ping Tang et al. · Cell | Mar 2005 | 889 |
| 23 | Long-Term Risk of Cardiovascular Disease in 10-Year Survivors of Breast Cancer Maartje J. Hooning, Akke Botma, Berthe M.P. Aleman et al. · JNCI Journal of the National Cancer Institute | 6 Mar 2007 | 876 |
| 24 | Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. John B. Welsh, Lisa M. Sapinoso, Andrew I. Su et al. · PubMed | 15 Aug 2001 | 857 |
| 25 | High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin Toshihiko Tanno, Natarajan V. Bhanu, Patricia Ann Oneal et al. · Nature Medicine | 26 Aug 2007 | 855 |
| 26 | Nrf2–Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species Makoto Kobayashi, Masayuki P. Yamamoto · Advances in Enzyme Regulation | 2006 | 855 |
| 27 | Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan Nataliya Libina, Jennifer R. Berman, Cynthia J. Kenyon · Cell | Nov 2003 | 853 |
| 28 | Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis Mark J Bolland, Andrew B. Grey, Alison Avenell et al. · BMJ | 19 Apr 2011 | 852 |
| 29 | Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle Manisha Barnwal Sinha, Young Charles Jang, Juhyun Oh et al. · Science | 5 May 2014 | 848 |
| 30 | Type 2 Innate Signals Stimulate Fibro/Adipogenic Progenitors to Facilitate Muscle Regeneration Jose E. Heredia, Lata Mukundan, Francis M. Chen et al. · Cell | Apr 2013 | 836 |
| 31 | GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates Shannon E. Mullican, Xiefan Lin‐Schmidt, Chen‐Ni Chin et al. · Nature Medicine | 28 Aug 2017 | 792 |
| 32 | Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses William Weidong Du, Weining Yang, Yu Chen et al. · European Heart Journal | 11 Feb 2016 | 770 |
| 33 | A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia Michele Petruzzelli, Martina Schweiger, Renate Schreiber et al. · Cell Metabolism | 17 Jul 2014 | 765 |
| 34 | The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance Changhan David Lee, Jennifer J. Zeng, Brian G. Drew et al. · Cell Metabolism | Mar 2015 | 746 |
| 35 | MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells Qing Ji, Xinbao Hao, Min Zhang et al. · PLoS ONE | 27 Aug 2009 | 690 |
| 36 | The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL Paul J. Emmerson et al. · Nature Medicine | 28 Aug 2017 | 686 |
| 37 | GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand Linda G. Yang et al. · Nature Medicine | 28 Aug 2017 | 685 |
| 38 | NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases Min Woo Park, Hyeon Woo Cha, Junhyung Kim et al. · Redox Biology | 20 Mar 2021 | 681 |
| 39 | A fermented milk high in bioactive peptides has a blood pressure–lowering effect in hypertensive subjects Leena Seppo, Tiina Jauhiainen, Tuija Annika Poussa et al. · American Journal of Clinical Nutrition | Feb 2003 | 671 |
| 40 | Cancer-Related Inflammation Juliana Candido, Thorsten Hagemann · Journal of Clinical Immunology | 8 Dec 2012 | 667 |
| 41 | Circular RNA (circRNA) in Alzheimer's disease (AD) Walter J. Lukiw · Frontiers in Genetics | 2013 | 654 |
| 42 | The Transforming Growth Factor-β Superfamily Member Growth-Differentiation Factor-15 Protects the Heart From Ischemia/Reperfusion Injury Tibor Kempf, Matthias Eden, Jens Strelau et al. · Circulation Research | 5 Jan 2006 | 653 |
| 43 | Folic Acid Deficiency and Homocysteine Impair DNA Repair in Hippocampal Neurons and Sensitize Them to Amyloid Toxicity in Experimental Models of Alzheimer's Disease Inna I. Kruman, T. S. Kumaravel, Althaf Lohani et al. · Journal of Neuroscience | Mar 2002 | 647 |
| 44 | Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies Rajiv Chowdhury, Setor K. Kunutsor, Anna Vitezova et al. · BMJ | Apr 2014 | 642 |
| 45 | Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15 Jer-Yuan Hsu et al. · Nature | 26 Sep 2017 | 632 |
| 46 | Humanin peptide suppresses apoptosis by interfering with Bax activation Bin Guo, Dayong Zhai, Edelmira Cabezas et al. · Nature | May 2003 | 629 |
| 47 | A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ Yuichi Hashimoto, Takako Niikura, Hirohisa Tajima et al. · Proceedings of the National Academy of Sciences | 22 May 2001 | 628 |
| 48 | Diagnosis and management of mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society Sumit Parikh, Amy C. Goldstein, Mary Kay Koenig et al. · Genetics in Medicine | 11 Dec 2014 | 628 |
| 49 | Quercetin alleviates acute kidney injury by inhibiting ferroptosis Yue Wang, Fei Quan, Qiuhua Cao et al. · Journal of Advanced Research | 21 Jul 2020 | 620 |
| 50 | Circulating Mononuclear Cells in the Obese Are in a Proinflammatory State Husam Ghanim, Ahmad Aljada, Deborah Hofmeyer et al. · Circulation | 13 Sep 2004 | 614 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.