Topic · Liver physiology and pathology
Most cited papers in Liver physiology and pathology
What are the most cited papers in Liver physiology and pathology?
The most cited paper in Liver physiology and pathology is "Sorafenib in Advanced Hepatocellular Carcinoma" (Josep Maria Llovet et al., 2008), with 13,116 citations. Next come "Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche" (7,361) and "Changes of Intestinal Functions in Liver Cirrhosis" (6,814).
Showing 50 of 98 papers. Every paper with more than 1,048 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Sorafenib in Advanced Hepatocellular Carcinoma Josep Maria Llovet et al. · New England Journal of Medicine | 23 Jul 2008 | 13,116 |
| 2 | Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche Toshiro Sato, Robert G.J. Vries, Hugo J.G. Snippert et al. · Nature | 29 Mar 2009 | 7,361 |
| 3 | Changes of Intestinal Functions in Liver Cirrhosis Hiroshi Fukui, Reiner Wiest · Inflammatory Intestinal Diseases | 2016 | 6,814 |
| 4 | Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial Masatoshi Kudo et al. · The Lancet | Mar 2018 | 5,578 |
| 5 | Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis Hashem B. El‐Serag, K. Lenhard Rudolph · Gastroenterology | Jun 2007 | 5,483 |
| 6 | Chapter 4 Preparation of Isolated Rat Liver Cells Per O. Seglen · Methods in cell biology | 1976 | 5,348 |
| 7 | Liver fibrosis Ramon A. Bataller, David A. Brenner · Journal of Clinical Investigation | Feb 2005 | 4,815 |
| 8 | A human colon cancer cell capable of initiating tumour growth in immunodeficient mice Catherine Adell O'Brien, Aaron F. Pollett, Steven Gallinger et al. · Nature | 19 Nov 2006 | 4,107 |
| 9 | Hepatocellular carcinoma Alejandro Forner, Josep Maria Llovet, Jordi Bruix · The Lancet | 20 Feb 2012 | 4,057 |
| 10 | Nonalcoholic Steatohepatitis: A Proposal for Grading and Staging The Histological Lesions Elizabeth M. Brunt, Christine G. Janney, Adrian M. Di Bisceglie et al. · The American Journal of Gastroenterology | Sep 1999 | 3,891 |
| 11 | Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium Toshiro Sato, Daniel E. Stange, Marc Ferrante et al. · Gastroenterology | 3 Sep 2011 | 3,882 |
| 12 | Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy Peter E. Czabotar, Guillaume Lessène, Andreas Strasser et al. · Nature Reviews Molecular Cell Biology | 20 Dec 2013 | 3,274 |
| 13 | Transforming Growth Factor β in Tissue Fibrosis Franklin H. Epstein, Wayne A. Border, Nancy A. Noble · New England Journal of Medicine | 10 Nov 1994 | 3,093 |
| 14 | Mechanisms of hepatic stellate cell activation Takuma Tsuchida, Scott L. Friedman · Nature Reviews Gastroenterology & Hepatology | 10 May 2017 | 2,956 |
| 15 | Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver Scott L. Friedman · Physiological Reviews | 2008 | 2,862 |
| 16 | Liver Regeneration George K. Michalopoulos, Marie C. DeFrances · Science | 4 Apr 1997 | 2,858 |
| 17 | THE DEVELOPMENT OF FIBROBLAST COLONIES IN MONOLAYER CULTURES OF GUINEA‐PIG BONE MARROW AND SPLEEN CELLS A. J. Friedenstein, R. K. Chailakhjan, K. S. Lalykina · Cell Proliferation | Oct 1970 | 2,717 |
| 18 | Mechanisms of Hepatic Fibrogenesis Scott L. Friedman · Gastroenterology | May 2008 | 2,649 |
| 19 | Met, metastasis, motility and more Carmen Birchmeier, Walter Birchmeier, Ermanno Gherardi et al. · Nature Reviews Molecular Cell Biology | Dec 2003 | 2,620 |
| 20 | Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients Marc van de Wetering et al. · Cell | May 2015 | 2,496 |
| 21 | Bone Marrow as a Potential Source of Hepatic Oval Cells Byron E. Petersen, William C. Bowen, K. D. Patrene et al. · Science | 14 May 1999 | 2,393 |
| 22 | Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma Ghassan K. Abou‐Alfa et al. · New England Journal of Medicine | 4 Jul 2018 | 2,386 |
| 23 | Purified hematopoietic stem cells can differentiate into hepatocytes in vivo Eric Lagasse, Heather L. Connors, Muhsen Al-Dhalimy et al. · Nature Medicine | Nov 2000 | 2,332 |
| 24 | Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product Donald Paul Bottaro, Jeffrey S. Rubin, Donna L. Faletto et al. · Science | 15 Feb 1991 | 2,257 |
| 25 | Vascularized and functional human liver from an iPSC-derived organ bud transplant Takanori Takebe, Keisuke Sekine, Masahiro Enomura et al. · Nature | 2 Jul 2013 | 2,202 |
| 26 | Molecular cloning and expression of human hepatocyte growth factor Toshikazu Nakamura, Tsutomu Nishizawa, Mitchio Hagiya et al. · Nature | Nov 1989 | 2,186 |
| 27 | Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury Scott L. Friedman · Journal of Biological Chemistry | 2000 | 2,099 |
| 28 | The Myofibroblast Boris Hinz, Sem Hin Phan, Victor John Thannickal et al. · American Journal Of Pathology | 19 Apr 2007 | 2,077 |
| 29 | Molecular and cellular mechanisms of liver fibrosis and its regression Tatiana Kisseleva, David A. Brenner · Nature Reviews Gastroenterology & Hepatology | 30 Oct 2020 | 2,046 |
| 30 | Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion Naohiro Terada, Takashi Hamazaki, Masahiro Oka et al. · Nature | 13 Mar 2002 | 2,003 |
| 31 | Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro Jason R. Spence, Christopher N. Mayhew, Scott A. Rankin et al. · Nature | 10 Dec 2010 | 1,974 |
| 32 | TLR4 enhances TGF-β signaling and hepatic fibrosis Ekihiro Seki, Samuele De Minicis, Christoph H. Österreicher et al. · Nature Medicine | 21 Oct 2007 | 1,950 |
| 33 | Liver cirrhosis Detlef Schuppan, Nezam H Afdhal · The Lancet | Mar 2008 | 1,919 |
| 34 | Resolving the fibrotic niche of human liver cirrhosis at single-cell level Prakash Ramachandran et al. · Nature | 9 Oct 2019 | 1,838 |
| 35 | Pathogenesis of Liver Fibrosis Virginia Hernández–Gea, Scott L. Friedman · Annual Review of Pathology Mechanisms of Disease | 24 Jan 2011 | 1,819 |
| 36 | Liver fibrosis – from bench to bedside Scott L. Friedman · Journal of Hepatology | 2003 | 1,794 |
| 37 | ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. IV. PROTECTIVE ROLE OF GLUTATHIONE J.R. Mitchell, David J. Jollow, William Z. Potter et al. · Journal of Pharmacology and Experimental Therapeutics | Oct 1973 | 1,755 |
| 38 | Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch et al. · Cell | 19 Dec 2014 | 1,658 |
| 39 | Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Jack Gauldie, Carl D. Richards, D.C. Harnish et al. · Proceedings of the National Academy of Sciences | Oct 1987 | 1,658 |
| 40 | In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration Meritxell Huch, Craig Dorrell, Sylvia F. Boj et al. · Nature | 25 Jan 2013 | 1,605 |
| 41 | TGF-β and epithelial-to-mesenchymal transitions Jiří Zavadil, Erwin P. Böttinger · Oncogene | 26 Aug 2005 | 1,599 |
| 42 | Liver regeneration: from myth to mechanism Rebecca A. Taub · Nature Reviews Molecular Cell Biology | Oct 2004 | 1,592 |
| 43 | Cell fusion is the principal source of bone-marrow-derived hepatocytes Xin Wang, Holger Willenbring, Yassmine M. N. Akkari et al. · Nature | 30 Mar 2003 | 1,575 |
| 44 | Comparison of Noninvasive Markers of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease Amy G. Shah, Alison D. Lydecker, Karen F. Murray et al. · Clinical Gastroenterology and Hepatology | 11 Jun 2009 | 1,561 |
| 45 | Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice Drew E. Cressman, Linda E. Greenbaum, Robert A. DeAngelis et al. · Science | 22 Nov 1996 | 1,533 |
| 46 | Human primary liver cancer–derived organoid cultures for disease modeling and drug screening Laura Broutier et al. · Nature Medicine | 13 Nov 2017 | 1,511 |
| 47 | Hepatic stellate cells as key target in liver fibrosis Takaaki Higashi, Scott L. Friedman, Yujin Hoshida · Advanced Drug Delivery Reviews | 12 May 2017 | 1,509 |
| 48 | Prevalence of Fatty Liver in Children and Adolescents Jeffrey B. Schwimmer, Reena Deutsch, Tanaz Kahen et al. · PEDIATRICS | Oct 2006 | 1,485 |
| 49 | Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium AF Olumi, GD Grossfeld, SW Hayward et al. · Breast Cancer Research | Mar 2000 | 1,474 |
| 50 | Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair Jeremy S. Duffield, Stuart John Forbes, Christothea M. Constandinou et al. · Journal of Clinical Investigation | 3 Jan 2005 | 1,448 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.