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Topic · Hepatology

Liver physiology and pathology

Liver physiology and pathology is a research topic within Hepatology. Science Explorer counts 28k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the mechanisms, cellular players, and therapeutic targets related to liver fibrosis. It covers topics such as the role of hepatic stellate cells, liver regeneration, TGF-ß signaling, macrophage involvement, MET signaling, oxidative stress, angiogenesis, hepatocyte growth factor, and inflammation in the pathogenesis and treatment of liver fibrosis.

  • Hepatic Stellate Cells
  • Liver Regeneration
  • TGF-ß Signaling
  • Macrophages
  • MET Signaling
  • Fibrogenesis
  • Oxidative Stress
  • Angiogenesis
  • Hepatocyte Growth Factor
  • Inflammation
Research works
28k
fractional, since 1950
In the world top 10%
2.7k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+6%
the tick is no change
Largest producer
China
50% of the 10 largest, 2022-now
Liver physiology and pathology

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Liver physiology and pathology research?

By volume, China and the United States publish the most (1.8k and 646 works in 2022-now).

By volume, 2022-now

  1. 1 China 1.8k works
  2. 2 United States 646 works
  3. 3 Japan 255 works
  4. 4 Germany 190 works
  5. 5 South Korea 158 works
  6. 6 India 138 works
  7. 7 Italy 105 works
  8. 8 Egypt 105 works
  9. 9 United Kingdom 102 works
  10. 10 France 81 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 50.1%United States: 18.1%Japan: 7.2%Germany: 5.3%6 others listed: 19.3%50%largest
China1,781 · 50.1%United States646 · 18.1%Japan255 · 7.2%Germany190 · 5.3%6 others listed687 · 19.3%

Shares of the rows listed above, not of the whole node.

Which institutions lead Liver physiology and pathology research?

By volume in 2022-now, Sun Yat-sen University publishes the most Liver physiology and pathology research, followed by Shanghai Jiao Tong University and Zhejiang University.

By volume, 2022-now

  1. 1 Sun Yat-sen UniversityChina 54 works
  2. 2 Shanghai Jiao Tong UniversityChina 41 works
  3. 3 Zhejiang UniversityChina 40 works
  4. 4 Chinese Academy of SciencesChina 36 works
  5. 5 Sichuan UniversityChina 35 works
  6. 6 Anhui Medical UniversityChina 32 works
  7. 7 Shanghai University of Traditional Chinese MedicineChina 32 works
  8. 8 Capital Medical UniversityChina 32 works
  9. 9 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 29 works
  10. 10 Huazhong University of Science and TechnologyChina 29 works

Who are the leading researchers in Liver physiology and pathology?

The most-cited researchers publishing on Liver physiology and pathology include Zhong Lin Wang, Guido Kroemer and Shizuo Akira.

  1. 1 Zhong Lin Wang United States 491k citations
  2. 2 Guido Kroemer France 386k citations
  3. 3 Shizuo Akira Japan 342k citations
  4. 4 Jun Wang China 340k citations
  5. 5 Matthias Mann Germany 308k citations
  6. 6 Róbert Langer United States 303k citations
  7. 7 Reza Malekzadeh Iran 278k citations
  8. 8 Michael Karin United States 276k citations
  9. 9 Gordon Brent Mills United States 265k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Liver physiology and pathology?

The most cited paper in Liver physiology and pathology is "Sorafenib in Advanced Hepatocellular Carcinoma" (Josep Maria Llovet et al., 2008), with 13,116 citations. Next come "Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche" (7,361) and "Changes of Intestinal Functions in Liver Cirrhosis" (6,814).

Most cited papers
#PaperReleasedCitations
1 Sorafenib in Advanced Hepatocellular Carcinoma Josep Maria Llovet et al. · New England Journal of Medicine Open access 23 Jul 2008 13,116
2 Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche Toshiro Sato, Robert G.J. Vries, Hugo J.G. Snippert et al. · Nature 29 Mar 2009 7,361
3 Changes of Intestinal Functions in Liver Cirrhosis Hiroshi Fukui, Reiner Wiest · Inflammatory Intestinal Diseases Open access 2016 6,814
4 Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial Masatoshi Kudo et al. · The Lancet Open access Mar 2018 5,578
5 Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis Hashem B. El‐Serag, K. Lenhard Rudolph · Gastroenterology Jun 2007 5,483
All 98 most cited papers, with filters and sorting

Where is Liver physiology and pathology research done?

The largest centres of Liver physiology and pathology research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Nanjing (China). Among places with at least 20 works in it, it is an unusually large share of all research in Wenzhou.

Largest cities, 2022-now

  1. 1 BeijingChina 209 works
  2. 2 ShanghaiChina 172 works
  3. 3 GuangzhouChina 131 works
  4. 4 NanjingChina 98 works
  5. 5 HangzhouChina 85 works
  6. 6 ChengduChina 72 works
  7. 7 SeoulSouth Korea 71 works
  8. 8 TokyoJapan 64 works
  9. 9 WuhanChina 60 works
  10. 10 HefeiChina 51 works

Where it is the local speciality

  1. WenzhouCN · 24.2 works6.4×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Liver physiology and pathology than the world average.

See Liver physiology and pathology on the map

Where is the best place to study Liver physiology and pathology?

Among universities, judged by research, Sun Yat-sen University, Nanjing University of Chinese Medicine and Zhejiang Chinese Medical University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 14.44%fractional works in this field (log) →share of work in the world top 10% →Zhejiang Chinese Med…Nanjing University o…Sun Yat-sen UniversitySichuan University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Sun Yat-sen UniversityChina 69.316.8%6.8×54 +37.0%
2Nanjing University of Chinese MedicineChina 58.217.1%22.9×22 +195.6%
3Zhejiang Chinese Medical UniversityChina 56.922.4%15.3×14 +630.5%
4Sichuan UniversityChina 56.814.7%4.1×35 +16.6%
5Anhui Medical UniversityChina 56.711.2%18.6×32 +40.8%
6Shanghai Jiao Tong UniversityChina 56.211.3%3.8×41 +22.1%
7China Pharmaceutical UniversityChina 55.212.8%29.4×25 +85.1%
8Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 54.712.4%7.3×29 +71.7%
9Chengdu University of Traditional Chinese MedicineChina 54.614.1%21.4×21 +182.1%
10Shanghai University of Traditional Chinese MedicineChina 54.211.6%31.0×32 +34.7%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Liver physiology and pathology, country by country

Is Liver physiology and pathology research growing?

Output in 2022-2025 was 6% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Liver physiology and pathology.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Liver physiology and pathology as a percentage of every work published that year, 0.016% in 2024.

still counting0.020%0.040%0.060%Liver physiology and pathology0.019% in 202519801990200020102020

Fractional works of Liver physiology and pathology over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Liver physiology and pathology10.2% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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