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Topic · Hepatology

Liver Diseases and Immunity

Liver Diseases and Immunity is a research topic within Hepatology. Science Explorer counts 21k research works in it since 1950. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the diagnosis, management, epidemiology, and genetic factors of autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosing cholangitis. It also covers topics such as liver transplantation, immunosuppressive therapy, and the pathogenesis of these liver diseases.

  • Autoimmune Hepatitis
  • Primary Biliary Cirrhosis
  • Primary Sclerosing Cholangitis
  • Diagnosis
  • Management
  • Epidemiology
  • Genome-wide Association Study
  • Liver Transplantation
  • Immunosuppressive Therapy
  • Pathogenesis
Research works
21k
fractional, since 1950
In the world top 10%
2.1k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+33%
the tick is no change
Largest producer
China
30% of the 10 largest, 2022-now
Liver Diseases and Immunity

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Liver Diseases and Immunity research?

By volume, China and the United States publish the most (1.1k and 965 works in 2022-now).

By volume, 2022-now

  1. 1 China 1.1k works
  2. 2 United States 965 works
  3. 3 Japan 260 works
  4. 4 India 225 works
  5. 5 Germany 220 works
  6. 6 Italy 210 works
  7. 7 United Kingdom 206 works
  8. 8 Spain 150 works
  9. 9 France 122 works
  10. 10 Canada 105 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 29.9%United States: 27.5%Japan: 7.4%India: 6.4%6 others listed: 28.8%30%largest
China1,052 · 29.9%United States965 · 27.5%Japan260 · 7.4%India225 · 6.4%6 others listed1,013 · 28.8%

Shares of the rows listed above, not of the whole node.

Which institutions lead Liver Diseases and Immunity research?

By volume in 2022-now, Capital Medical University publishes the most Liver Diseases and Immunity research, followed by Mayo Clinic and Harvard University.

By volume, 2022-now

  1. 1 Capital Medical UniversityChina 40 works
  2. 2 Mayo ClinicUnited States 37 works
  3. 3 Harvard UniversityUnited States 36 works
  4. 4 Sun Yat-sen UniversityChina 34 works
  5. 5 Shanghai Jiao Tong UniversityChina 29 works
  6. 6 Peking UniversityChina 28 works
  7. 7 Sichuan UniversityChina 27 works
  8. 8 Zhejiang UniversityChina 26 works
  9. 9 University of TorontoCanada 23 works
  10. 10 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 22 works

Who are the leading researchers in Liver Diseases and Immunity?

The most-cited researchers publishing on Liver Diseases and Immunity include Douglas G. Altman, Walter Churchill Willett and Mark J. Daly.

  1. 1 Douglas G. Altman United Kingdom 862k citations
  2. 2 Walter Churchill Willett United States 411k citations
  3. 3 Mark J. Daly United States 403k citations
  4. 4 Guido Kroemer France 386k citations
  5. 5 Jun Wang China 340k citations
  6. 6 Giuseppe Remuzzi Italy 328k citations
  7. 7 John P. A. Ioannidis United States 317k citations
  8. 8 Gordon Henry Guyatt Canada 315k citations
  9. 9 Dan J. Stein South Africa 306k citations
  10. 10 Sadaf Ghajarieh Sepanlou Iran 282k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Liver Diseases and Immunity?

The most cited paper in Liver Diseases and Immunity is "Histological grading and staging of chronic hepatitis" (Kamal G. Ishak, Amélia Baptista, Leonardo Bianchi et al., 1995), with 5,081 citations. Next come "An Algorithm for the Grading of Activity in Chronic Hepatitis C" (4,058) and "Burden of liver diseases in the world" (3,840).

Most cited papers
#PaperReleasedCitations
1 Histological grading and staging of chronic hepatitis Kamal G. Ishak, Amélia Baptista, Leonardo Bianchi et al. · Journal of Hepatology Jun 1995 5,081
2 An Algorithm for the Grading of Activity in Chronic Hepatitis C Pierre Bédossa, Thierry Poynard · Hepatology Open access Aug 1996 4,058
3 Burden of liver diseases in the world Sumeet K. Asrani, Harshad C. Devarbhavi, John E. Eaton et al. · Journal of Hepatology 25 Sep 2018 3,840
4 Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis† Robert G. Knodell, Kamal G. Ishak, William C. Black et al. · Hepatology Open access Sep 1981 3,575
5 Interferon Alfa-2b Alone or in Combination with Ribavirin as Initial Treatment for Chronic Hepatitis C John G. McHutchison, Stuart C. Gordon, Eugene R. Schiff et al. · New England Journal of Medicine Open access 19 Nov 1998 3,509
All 100 most cited papers, with filters and sorting

Where is Liver Diseases and Immunity research done?

The largest centres of Liver Diseases and Immunity research in 2022-now are Beijing (China), Shanghai (China), London (United Kingdom) and Guangzhou (China).

Largest cities, 2022-now

  1. 1 BeijingChina 171 works
  2. 2 ShanghaiChina 93 works
  3. 3 LondonUnited Kingdom 69 works
  4. 4 GuangzhouChina 68 works
  5. 5 TokyoJapan 62 works
  6. 6 ParisFrance 56 works
  7. 7 SeoulSouth Korea 56 works
  8. 8 New YorkUnited States 54 works
  9. 9 NanjingChina 51 works
  10. 10 HangzhouChina 49 works
See Liver Diseases and Immunity on the map

Where is the best place to study Liver Diseases and Immunity?

Among universities, judged by research, Karolinska Institutet, University of California San Diego and Harvard University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 15.94%fractional works in this field (log) →share of work in the world top 10% →University of Califo…University of OsloKarolinska InstitutetHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Karolinska InstitutetSweden 69.516.1%8.4×21 +55.5%
2University of California San DiegoUnited States 67.628.9%3.2×13 +24.7%
3Harvard UniversityUnited States 66.714.3%2.6×36 +33.3%
4University of OsloNorway 63.025.8%3.4×10 +31.3%
5University of TorontoCanada 59.715.0%2.6×23 +25.5%
6Zhejiang UniversityChina 57.818.9%2.3×26 +79.9%
7King's College LondonUnited Kingdom 57.18.9%5.5×21 +19.6%
8Capital Medical UniversityChina 56.76.3%8.7×40 +107.5%
9Yale UniversityUnited States 56.014.0%4.2×20 +35.8%
10Sun Yat-sen UniversityChina 55.511.2%3.7×34 +121.4%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Liver Diseases and Immunity, country by country

Is Liver Diseases and Immunity research growing?

Output in 2022-2025 was 33% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Liver Diseases and Immunity.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Liver Diseases and Immunity as a percentage of every work published that year, 0.019% in 2024.

still counting0.020%0.040%Liver Diseases and Immunity0.023% in 202519801990200020102020

Fractional works of Liver Diseases and Immunity over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Liver Diseases and Immunity10.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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