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Topic · Phosphodiesterase function and regulation

Most cited papers in Phosphodiesterase function and regulation

Phosphodiesterase function and regulation

What are the most cited papers in Phosphodiesterase function and regulation?

The most cited paper in Phosphodiesterase function and regulation is "Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension" (Nazzareno Galiè, Hossein Ardeschir Ghofrani, Adam Torbicki et al., 2005), with 2,489 citations. Next come "Oral Sildenafil in the Treatment of Erectile Dysfunction" (2,158) and "Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis" (1,936).

Showing 50 of 100 papers. Every paper with more than 560 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension Nazzareno Galiè, Hossein Ardeschir Ghofrani, Adam Torbicki et al. · New England Journal of Medicine Open access 16 Nov 2005 2,489
2 Oral Sildenafil in the Treatment of Erectile Dysfunction Irwin Goldstein, Tom F. Lue, Harin Padma-Nathan et al. · New England Journal of Medicine 14 May 1998 2,158
3 Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis Stefan Leucht, Caroline Corves, Dieter Arbter et al. · The Lancet Review 7 Dec 2008 1,936
4 Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms Joseph A. Beavo · Physiological Reviews Oct 1995 1,793
5 Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use Andrew T. Bender, Joseph A. Beavo · Pharmacological Reviews Sep 2006 1,793
6 Schizophrenia—An Overview Robert Ali McCutcheon, Tiago Reis Marques, Oliver Howes · JAMA Psychiatry 30 Oct 2019 1,485
7 Survival in Patients With Idiopathic, Familial, and Anorexigen-Associated Pulmonary Arterial Hypertension in the Modern Management Era Marc Humbert et al. · Circulation 29 Jun 2010 1,404
8 A Family of cAMP-Binding Proteins That Directly Activate Rap1 Hiroaki Kawasaki, Gregory M. Springett, Naoki Mochizuki et al. · Science 18 Dec 1998 1,380
9 Disruption of two novel genes by a translocation co-segregating with schizophrenia J. Kirsty Millar · Human Molecular Genetics Open access 22 May 2000 1,272
10 Guanylyl Cyclases and Signaling by Cyclic GMP Kimberly A. Lucas, Giovanni Mario Pitari, Shiva Kazerounian et al. · Pharmacological Reviews Sep 2000 1,227
11 Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus Masashi Nibuya, EJ Nestler, R. S. Duman · Journal of Neuroscience Open access Apr 1996 1,214
12 Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling Marco Conti, Joseph A. Beavo · Annual Review of Biochemistry Review 9 Feb 2007 1,199
13 Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension Nazzareno Galiè, Joan Albert Barberà, Adaani Frost et al. · New England Journal of Medicine Open access 26 Aug 2015 1,188
14 Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease Gabriella Marucci, Michela Buccioni, Diego Dal Ben et al. · Neuropharmacology Open access 6 Oct 2020 1,126
15 Recent advances in Alzheimer’s disease: mechanisms, clinical trials and new drug development strategies Jifa Zhang, Yinglu Zhang, Jiaxing Wang et al. · Signal Transduction and Targeted Therapy Open access 23 Aug 2024 1,113
16 Tadalafil Therapy for Pulmonary Arterial Hypertension Nazzareno Galiè, Bruce H. Brundage, Hossein Ardeschir Ghofrani et al. · Circulation 26 May 2009 1,109
17 Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits Wei‐Jen Tang, Alfred G. Gilman · Science 6 Dec 1991 1,100
18 Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial René S. Kahn, W. Wolfgang Fleischhacker, Han Boter et al. · The Lancet Mar 2008 1,091
19 Selexipag for the Treatment of Pulmonary Arterial Hypertension Olivier Sitbon, Richard N. Channick, Kelly Chin et al. · New England Journal of Medicine Open access 23 Dec 2015 1,071
20 Randomized Controlled Trial of Interventions Designed to Reduce the Risk of Progression to First-Episode Psychosis in a Clinical Sample With Subthreshold Symptoms Patrick D. McGorry, Alison Ruth Yung, Lisa Phillips et al. · Archives of General Psychiatry Open access Oct 2002 1,061
21 cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway Mark R. Vossler, Hong Wei Yao, Randall D. York et al. · Cell Open access Apr 1997 1,061
22 cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action Sharron H. Francis, Jennifer L. Busch, Jackie D. Corbin · Pharmacological Reviews Open access 17 Aug 2010 1,036
23 Cognitive endophenotypes of bipolar disorder: A meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives Emre Bora, Murat Yücel, Christos Pantelis · Journal of Affective Disorders Review 6 Aug 2008 1,032
24 Nitric Oxide as a Mediator of Relaxation of the Corpus Cavernosum in Response to Nonadrenergic, Noncholinergic Neurotransmission Jacob Rajfer, William J. Aronson, Margaret A. Bush et al. · New England Journal of Medicine Open access 9 Jan 1992 1,024
25 Neural and developmental actions of lithium: A unifying hypothesis Michael John Berridge, C. Peter Downes, Michael R. Hanley · Cell Nov 1989 1,018
26 Natriuretic Peptides, Their Receptors, and Cyclic Guanosine Monophosphate-Dependent Signaling Functions Lincoln Ross Potter, Sarah E. Abbey‐Hosch, Deborah M. Dickey · Endocrine Reviews 16 Nov 2005 1,014
27 Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction Sanjiv Jayendra Shah, Dalane W. Kitzman, Barry A. Borlaug et al. · Circulation Open access 29 Jun 2016 1,007
28 Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase Shamshad Cockcroft, Bastien D. Gomperts · Nature Apr 1985 959
29 Cyclic nucleotide research — still expanding after half a century Joseph A. Beavo, Laurence L. Brunton · Nature Reviews Molecular Cell Biology Review Sep 2002 914
30 Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation Philip A. Stork, John Schmitt · Trends in Cell Biology Review Jun 2002 904
31 Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy Eiki Takimoto, Hunter C. Champion, Manxiang Li et al. · Nature Medicine 23 Jan 2005 904
32 Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents Claire Lugnier · Pharmacology & Therapeutics 16 Aug 2005 873
33 Retinal degeneration in the rd mouse is caused by a defect in the β subunit of rod cGMP-phosphodiesterase Cathy Bowes, Tiansen Li, Michael Danciger et al. · Nature Oct 1990 859
34 Storage of Spatial Information by the Maintenance Mechanism of LTP Eva Pastalkova, Peter A. Serrano, Deana Pinkhasova et al. · Science 24 Aug 2006 859
35 Discrete Microdomains with High Concentration of cAMP in Stimulated Rat Neonatal Cardiac Myocytes Manuela Zaccolo, Tullio Pozzan · Science Mar 2002 858
36 Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors Joseph A. Beavo, David H. Reifsnyder · Trends in Pharmacological Sciences Review Apr 1990 853
37 Comparative pharmacology of calcium antagonists: Nifedipine, verapamil and diltiazem Philip D. Henry · The American Journal of Cardiology Dec 1980 851
38 Structural Brain Magnetic Resonance Imaging of Limbic and Thalamic Volumes in Pediatric Bipolar Disorder Jean A. Frazier, Sufen Chiu, Janis L. Breeze et al. · American Journal of Psychiatry 30 Jun 2005 848
39 Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials Peter M.A. Calverley, Klaus Friedrich Rabe, Udo-Michael Goehring et al. · The Lancet Open access Aug 2009 830
40 Cyclic 3′,5′-nucleotide phosphodiesterase Wai Yiu Cheung · Biochemical and Biophysical Research Communications Feb 1970 827
41 Overview of PDEs and Their Regulation Kenji Omori, Jun Kotera · Circulation Research 16 Feb 2007 808
42 Advances in targeting cyclic nucleotide phosphodiesterases Donald H. Maurice, Hengming Ke, Faiyaz Ahmad et al. · Nature Reviews Drug Discovery ReviewOpen access Apr 2014 790
43 Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling Yingwei Mao, Xuecai Ge, Christopher L. Frank et al. · Cell Open access Mar 2009 786
44 Localized Effects of cAMP Mediated by Distinct Routes of Protein Kinase A Kjetil Taskén, Einar Martin Aandahl · Physiological Reviews Review 2004 782
45 Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State Matthew P. Patricelli, Matthew Robert Janes, Lian‐Sheng Li et al. · Cancer Discovery 6 Jan 2016 770
46 PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization Miles D. Houslay, David R. Adams · Biochemical Journal Open access 15 Feb 2003 765
47 Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function Paolo Serafini, Kristen F. Meckel, Michael J. Kelso et al. · The Journal of Experimental Medicine Open access 13 Nov 2006 764
48 Safety and efficacy of erenumab for preventive treatment of chronic migraine: a randomised, double-blind, placebo-controlled phase 2 trial Stewart J. Tepper, Messoud Ashina, Uwe Reuter et al. · The Lancet Neurology 28 Apr 2017 747
49 Schizophrenia and Affective Disorders—Cosegregation with a Translocation at Chromosome 1q42 That Directly Disrupts Brain-Expressed Genes: Clinical and P300 Findings in a Family Douglas Blackwood, Alison Fordyce, Maura T. Walker et al. · The American Journal of Human Genetics Open access Aug 2001 745
50 Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions Scott H. Soderling, Joseph A. Beavo · Current Opinion in Cell Biology Review Apr 2000 743

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.